prikaz prve stranice dokumenta Arbutin and its metabolite hydroquinone as the main factors in the antimicrobial effect of strawberry tree (Arbutus unedo L.) leaves
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Scientific paper - Original scientific paper
Arbutin and its metabolite hydroquinone as the main factors in the antimicrobial effect of strawberry tree (Arbutus unedo L.) leaves
Journal of Herbal Medicine, 8 (2017); 17-23. https://doi.org/10.1016/j.hermed.2017.03.006
Jurica, Karlo; Gobin, Ivana; Kremer, Dario; Vitali Čepo, Dubravka; Jurišić Grubešić, Renata; Brčić Karačonji, Irena; Kosalec, Ivan

Institutional repository: Repository of the University of Rijeka, Faculty of Medicine

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Jurica, K., Gobin, I., Kremer, D., Vitali Čepo, D., Jurišić Grubešić, R., Brčić Karačonji, I. & Kosalec, I. (2017). Arbutin and its metabolite hydroquinone as the main factors in the antimicrobial effect of strawberry tree (Arbutus unedo L.) leaves. Journal of Herbal Medicine, 8., 17-23. doi: 10.1016/j.hermed.2017.03.006

Jurica, Karlo, et al. "Arbutin and its metabolite hydroquinone as the main factors in the antimicrobial effect of strawberry tree (Arbutus unedo L.) leaves." Journal of Herbal Medicine, vol. 8, 2017, pp. 17-23. https://doi.org/10.1016/j.hermed.2017.03.006

Jurica, Karlo, Ivana Gobin, Dario Kremer, Dubravka Vitali Čepo, Renata Jurišić Grubešić, Irena Brčić Karačonji and Ivan Kosalec. "Arbutin and its metabolite hydroquinone as the main factors in the antimicrobial effect of strawberry tree (Arbutus unedo L.) leaves." Journal of Herbal Medicine 8 (2017): 17-23. https://doi.org/10.1016/j.hermed.2017.03.006

Jurica, K., et al. (2017) 'Arbutin and its metabolite hydroquinone as the main factors in the antimicrobial effect of strawberry tree (Arbutus unedo L.) leaves', Journal of Herbal Medicine, 8, pp. 17-23. doi: 10.1016/j.hermed.2017.03.006

Jurica K, Gobin I, Kremer D, Vitali Čepo D, Jurišić Grubešić R, Brčić Karačonji I, and sur.. Arbutin and its metabolite hydroquinone as the main factors in the antimicrobial effect of strawberry tree (Arbutus unedo L.) leaves. Journal of Herbal Medicine [Internet]. 2017 [cited 2024 December 27];8:17-23. doi: 10.1016/j.hermed.2017.03.006

K. Jurica, et al., "Arbutin and its metabolite hydroquinone as the main factors in the antimicrobial effect of strawberry tree (Arbutus unedo L.) leaves", Journal of Herbal Medicine, vol. 8, pp. 17-23, 2017. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:154460. [Accessed: 27 December 2024]

Metadata
Title (english)Arbutin and its metabolite hydroquinone as the main factors in the antimicrobial effect of strawberry tree (Arbutus unedo L.) leaves
AuthorKarlo Jurica
MBZ: 354371
AuthorIvana Gobin
AuthorDario Kremer
MBZ: 240541
AuthorDubravka Vitali Čepo
MBZ: 257935
AuthorRenata Jurišić Grubešić
MBZ: 225555
AuthorIrena Brčić Karačonji
MBZ: 236105
AuthorIvan Kosalec
MBZ: 218392
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Microbiology and Parasitology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Medical Microbiology
Abstract (english)
Strawberry tree (Arbutus unedo L.) leaves are used in folk medicine for treating inflammation, hypertension, and diabetes. The aims of this study were to evaluate the antimicrobial effects of A. unedo leaf extracts on 15 uropathogens and test the extent to which arbutin, as the most abundant bioactive compound in the leaves, is responsible for their antimicrobial activity. Antimicrobial activity of leaf extracts against urinary pathogenic microorganisms was tested by agar well diffusion assay and twofolded microdilution method. Since the polyphenolic content responsible for A. unedo leaves’ antimicrobial activity depends on climate and geolocation, we determined the total phenolic, tannin, flavonoid and phenolic acid content using spectrophotometric methods, arbutin and hydroquinone mass fraction using high performance liquid chromatography coupled with a diode array detector (HPLC-DAD) and antioxidative activities by FRAP, ABTS, and DPPH assay. Although methanol was shown to be a more effective solvent for the extraction of polyphenols from leaves, water extract which could be used in clinical practice, exhibited similar antimicrobial properties. While arbutin did not show direct antimicrobial activity, its metabolite hydroquinone showed strong antimicrobial activity against the tested uropathogens. The strongest antimicrobial activity of leaf extracts was detected for uropathogenic strains of Enterococcus faecalis, which was probably associated with the ability of bacterial β-glucosidase, exerting strong activity in E. faecalis, to convert arbutin to hydroquinone. Our study suggests that strawberry tree water leaf extract has great potential as a phytotherapeutic in clinical application and should be further investigated.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionAccepted version
Journal titleJournal of Herbal Medicine
Numberingvol. 8, pp. 17-23
p-ISSN2210-8033
DOIhttps://doi.org/10.1016/j.hermed.2017.03.006
URN:NBNurn:nbn:hr:184:154460
Publication2017
Document URLhttp://bib.irb.hr/866536
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) icon
Created on2022-02-10 15:28:28