prikaz prve stranice dokumenta Clinical, virological, and immunological findings in patients with Toscana neuroinvasive disease in Croatia: report of three cases
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Scientific paper - Case study
Clinical, virological, and immunological findings in patients with Toscana neuroinvasive disease in Croatia: report of three cases
Tropical Medicine and Infectious Disease, 5(3) (2020); 1-7. https://doi.org/10.3390/tropicalmed5030144
Vilibić-Čavlek, Tatjana; Zidovec-Lepej, Snježana; Ledina, Dragan; Knežević, Samira; Savić, Vladimir; Tabain, Irena; Ivić, Ivo; Slavuljica, Irena; Bogdanić, Maja; Grgic, Ivana; Gorenec, Lana; Stevanović, Vladimir; Barbić, Ljubo

Institutional repository: Repository of the University of Rijeka, Faculty of Medicine

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Vilibić Čavlek, T., Zidovec Lepej, S., Ledina, D., Knežević, S., Savić, V., Tabain, I. ... Barbić, Lj. (2020). Clinical, virological, and immunological findings in patients with Toscana neuroinvasive disease in Croatia: report of three cases. Tropical Medicine and Infectious Disease, 5(3)., 1-7. doi: 10.3390/tropicalmed5030144

Vilibić Čavlek, Tatjana, et al. "Clinical, virological, and immunological findings in patients with Toscana neuroinvasive disease in Croatia: report of three cases." Tropical Medicine and Infectious Disease, vol. 5(3), 2020, pp. 1-7. https://doi.org/10.3390/tropicalmed5030144

Vilibić Čavlek, Tatjana, Snježana Zidovec Lepej, Dragan Ledina, Samira Knežević, Vladimir Savić, Irena Tabain, Ivo Ivić, et al. "Clinical, virological, and immunological findings in patients with Toscana neuroinvasive disease in Croatia: report of three cases." Tropical Medicine and Infectious Disease 5(3) (2020): 1-7. https://doi.org/10.3390/tropicalmed5030144

Vilibić Čavlek, T., et al. (2020) 'Clinical, virological, and immunological findings in patients with Toscana neuroinvasive disease in Croatia: report of three cases', Tropical Medicine and Infectious Disease, 5(3), pp. 1-7. doi: 10.3390/tropicalmed5030144

Vilibić Čavlek T, Zidovec Lepej S, Ledina D, Knežević S, Savić V, Tabain I, and sur.. Clinical, virological, and immunological findings in patients with Toscana neuroinvasive disease in Croatia: report of three cases. Tropical Medicine and Infectious Disease [Internet]. 2020 [cited 2024 August 29];5(3):1-7. doi: 10.3390/tropicalmed5030144

T. Vilibić Čavlek, et al., "Clinical, virological, and immunological findings in patients with Toscana neuroinvasive disease in Croatia: report of three cases", Tropical Medicine and Infectious Disease, vol. 5(3), pp. 1-7, 2020. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:142996. [Accessed: 29 August 2024]

Metadata
Title (english)Clinical, virological, and immunological findings in patients with Toscana neuroinvasive disease in Croatia: report of three cases
AuthorTatjana Vilibić-Čavlek
AuthorSnježana Zidovec-Lepej
AuthorDragan Ledina
AuthorSamira Knežević
AuthorVladimir Savić
AuthorIrena Tabain
AuthorIvo Ivić
AuthorIrena Slavuljica
AuthorMaja Bogdanić
AuthorIvana Grgic
AuthorLana Gorenec
AuthorVladimir Stevanović
AuthorLjubo Barbić
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Infectious Diseases)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Infectology
Abstract (english)
Toscana virus (TOSV) is an arthropod-borne virus, transmitted to humans by phlebotomine sandflies. Although the majority of infections are asymptomatic, neuroinvasive disease may occur. We report three cases of neuroinvasive TOSV infection detected in Croatia. Two patients aged 21 and 54 years presented with meningitis, while a 22-year old patient presented with meningoencephalitis and right- sided brachial plexitis. Cerebrospinal fluid (CSF), serum, and urine samples were collected and tested for neuroinvasive arboviruses: tick- borne encephalitis, West Nile, Usutu, TOSV, Tahyna, and Bhanja virus. In addition, CSF and serum samples were tested for the anti-viral cytokine response. High titers of TOSV IgM (1000–3200) and IgG (3200−10, 000) antibodies in serum samples confirmed TOSV infection. Antibodies to other phleboviruses (sandfly fever Sicilian/Naples/Cyprus virus) were negative. CSF samples showed high concentrations of interleukin 6 (IL-6 ; range 162.32−2683.90 pg/mL), interferon gamma (IFN-γ ; range 110.12−1568.07 pg/mL), and IL-10 (range 28.08−858.91 pg/mL), while significantly lower cytokine production was observed in serum. Two patients recovered fully. The patient with a brachial plexitis improved significantly at discharge. The presented cases highlight the need of increasing awareness of a TOSV as a possible cause of aseptic meningitis/ meningoencephalitis during summer months. Association of TOSV and brachial plexitis with long-term sequelae detected in one patient indicates the possibility of more severe disease, even in young patients.
Keywords (english)
Languageenglish
Publication typeScientific paper - Case study
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleTropical Medicine and Infectious Disease
Numberingvol. 5(3), pp. 1-7
e-ISSN2414-6366
DOIhttps://doi.org/10.3390/tropicalmed5030144
URN:NBNurn:nbn:hr:184:142996
Publication2020
Document URLhttp://bib.irb.hr/1087127
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2022-02-11 15:46:37