prikaz prve stranice dokumenta Cocoa polyphenols exhibit antioxidant, anti-inflammatory, anticancerogenic and anti-necrotic activity in carbon tetrachloride-intoxicated mice
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Scientific paper - Original scientific paper
Cocoa polyphenols exhibit antioxidant, anti-inflammatory, anticancerogenic and anti-necrotic activity in carbon tetrachloride-intoxicated mice
Journal of Functional Foods, 23 (2016); 177-187. https://doi.org/10.1016/j.jff.2016.02.036
Giacometti, Jasminka; Muhvić, Damir; Pavletić, Adriano; Đudarić, Luka

Institutional repository: Repository of the University of Rijeka, Faculty of Medicine

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Giacometti, J., Muhvić, D., Pavletić, A. & Đudarić, L. (2016). Cocoa polyphenols exhibit antioxidant, anti-inflammatory, anticancerogenic and anti-necrotic activity in carbon tetrachloride-intoxicated mice. Journal of Functional Foods, 23., 177-187. doi: 10.1016/j.jff.2016.02.036

Giacometti, Jasminka, et al. "Cocoa polyphenols exhibit antioxidant, anti-inflammatory, anticancerogenic and anti-necrotic activity in carbon tetrachloride-intoxicated mice." Journal of Functional Foods, vol. 23, 2016, pp. 177-187. https://doi.org/10.1016/j.jff.2016.02.036

Giacometti, Jasminka, Damir Muhvić, Adriano Pavletić and Luka Đudarić. "Cocoa polyphenols exhibit antioxidant, anti-inflammatory, anticancerogenic and anti-necrotic activity in carbon tetrachloride-intoxicated mice." Journal of Functional Foods 23 (2016): 177-187. https://doi.org/10.1016/j.jff.2016.02.036

Giacometti, J., et al. (2016) 'Cocoa polyphenols exhibit antioxidant, anti-inflammatory, anticancerogenic and anti-necrotic activity in carbon tetrachloride-intoxicated mice', Journal of Functional Foods, 23, pp. 177-187. doi: 10.1016/j.jff.2016.02.036

Giacometti J, Muhvić D, Pavletić A, Đudarić L. Cocoa polyphenols exhibit antioxidant, anti-inflammatory, anticancerogenic and anti-necrotic activity in carbon tetrachloride-intoxicated mice. Journal of Functional Foods [Internet]. 2016 [cited 2024 May 12];23:177-187. doi: 10.1016/j.jff.2016.02.036

J. Giacometti, D. Muhvić, A. Pavletić and L. Đudarić, "Cocoa polyphenols exhibit antioxidant, anti-inflammatory, anticancerogenic and anti-necrotic activity in carbon tetrachloride-intoxicated mice", Journal of Functional Foods, vol. 23, pp. 177-187, 2016. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:183522. [Accessed: 12 May 2024]

Metadata
Title (english)Cocoa polyphenols exhibit antioxidant, anti-inflammatory, anticancerogenic and anti-necrotic activity in carbon tetrachloride-intoxicated mice
AuthorJasminka Giacometti
MBZ: 177203
AuthorDamir Muhvić
AuthorAdriano Pavletić
AuthorLuka Đudarić
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Anatomy)
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Physiology, Immunology and Pathophxsiology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Chemistry
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Biology
Abstract (english)
The therapeutic effects of cocoa polyphenols on acute carbon tetrachloride (CCl4) -intoxicated mice were investigated. After determination polyphenols profile in the cocoa extract (CE), CE at a dose of 34.5 mg/kg and epicatechin (EC) at a dose of 2.24 mg/kg were intraperitoneally (i.p.) administered to BALB/cN mice following CCl4-treatment. CE and EC post-treatments suppressed hepatotoxicity and inflammation, ameliorated serum markers of liver injury, returned blood lactate and glucose levels to normal, stimulated synthesis and storage of liver glycogen, and modulated glucose metabolism imbalance induced by CCl4. Cocoa polyphenols also exhibited early stage antifibrotic and anticarcinogenic effects. They affected beneficially mitochondrial functionality acting on dysfunction in mitochondrial respiration caused by CCl4 and antioxidants regulation at subcellular levels.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleJournal of Functional Foods
Numberingvol. 23, pp. 177-187
p-ISSN1756-4646
DOIhttps://doi.org/10.1016/j.jff.2016.02.036
URN:NBNurn:nbn:hr:184:183522
Publication2016
Document URLhttp://bib.irb.hr/796164
Type of resourceText
Access conditionsClosed access
Terms of useLicence In copyright icon
Created on2022-02-11 16:19:27