prikaz prve stranice dokumenta Different combinations of maternal and postnatal diet are reflected in changes of hepatic parenchyma and hepatic TNF-alpha expression in male rat offspring
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Scientific paper - Original scientific paper
Different combinations of maternal and postnatal diet are reflected in changes of hepatic parenchyma and hepatic TNF-alpha expression in male rat offspring
Acta Histochemica, 119 (2017), 7; 719-726. https://doi.org/10.1016/j.acthis.2017.09.003
Perić Kačarević, Željka; Grgić, Anđela; Šnajder, Darija; Bijelić, Nikola; Belovari, Tatjana; Cvijanović, Olga; Blažičević, Valerija; Radić, Radivoje

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Perić Kačarević, Ž., Grgić, A., Šnajder, D., Bijelić, N., Belovari, T., Cvijanović, O. ... Radić, R. (2017). Different combinations of maternal and postnatal diet are reflected in changes of hepatic parenchyma and hepatic TNF-alpha expression in male rat offspring. Acta Histochemica, 119. (7), 719-726. doi: 10.1016/j.acthis.2017.09.003

Perić Kačarević, Željka, et al. "Different combinations of maternal and postnatal diet are reflected in changes of hepatic parenchyma and hepatic TNF-alpha expression in male rat offspring." Acta Histochemica, vol. 119, no. 7, 2017, pp. 719-726. https://doi.org/10.1016/j.acthis.2017.09.003

Perić Kačarević, Željka, Anđela Grgić, Darija Šnajder, Nikola Bijelić, Tatjana Belovari, Olga Cvijanović, Valerija Blažičević and Radivoje Radić. "Different combinations of maternal and postnatal diet are reflected in changes of hepatic parenchyma and hepatic TNF-alpha expression in male rat offspring." Acta Histochemica 119, no. 7 (2017): 719-726. https://doi.org/10.1016/j.acthis.2017.09.003

Perić Kačarević, Ž., et al. (2017) 'Different combinations of maternal and postnatal diet are reflected in changes of hepatic parenchyma and hepatic TNF-alpha expression in male rat offspring', Acta Histochemica, 119(7), pp. 719-726. doi: 10.1016/j.acthis.2017.09.003

Perić Kačarević Ž, Grgić A, Šnajder D, Bijelić N, Belovari T, Cvijanović O, and sur.. Different combinations of maternal and postnatal diet are reflected in changes of hepatic parenchyma and hepatic TNF-alpha expression in male rat offspring. Acta Histochemica [Internet]. 2017 [cited 2024 May 18];119(7):719-726. doi: 10.1016/j.acthis.2017.09.003

Ž. Perić Kačarević, et al., "Different combinations of maternal and postnatal diet are reflected in changes of hepatic parenchyma and hepatic TNF-alpha expression in male rat offspring", Acta Histochemica, vol. 119, no. 7, pp. 719-726, 2017. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:378578. [Accessed: 18 May 2024]

Metadata
Title (english)Different combinations of maternal and postnatal diet are reflected in changes of hepatic parenchyma and hepatic TNF-alpha expression in male rat offspring
AuthorŽeljka Perić Kačarević
MBZ: 329961
AuthorAnđela Grgić
MBZ: 334740
AuthorDarija Šnajder
MBZ: 310726
AuthorNikola Bijelić
MBZ: 313935
AuthorTatjana Belovari
MBZ: 209063
AuthorOlga Cvijanović
MBZ: 269863
AuthorValerija Blažičević
MBZ: 232314
AuthorRadivoje Radić
MBZ: 215984
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Anatomy)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Abstract (english)
Obesity is related to increased TNF-alpha production in different tissues. TNF-alpha is connected to mitochondrial dysfunction in the liver and also development of fatty infiltration of the liver. Also, postnatal change from normal to high-fat diet causes a significant increase in TNF-alpha serum levels. The aim of this research was to determine how maternal diet and switching male offspring to a different dietary regime after lactation influences rat liver. Ten female Sprague Dawley rats at nine weeks of age were randomly divided in two groups and fed either standard laboratory chow or high-fat diet during six weeks, and then mated with the same male subject. After birth and lactation male offspring from both groups were further divided into four subgroups depending on their subsequent diet. At 22 weeks of age, the animals were weighted, sacrificed and major organs were collected and weighted. Immunohistochemistry for TNF-alpha was performed on liver, and liver samples were analyzed for pathohistological changes. The group in which mothers were fed standard chow and offspring high-fat diet had the most pronounced changes: heaviest liver, poorest histopathological findings and strongest TNF- alpha immunohistochemical staining of liver parenchyma. High-fat diet during pregnancy and lactation and switching to high-fat diet postnatally affects liver weight, histological structure and TNF-alpha expression in male offspring.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionAccepted version
Journal titleActa Histochemica
Numberingvol. 119, no. 7, pp. 719-726
p-ISSN0065-1281
DOIhttps://doi.org/10.1016/j.acthis.2017.09.003
URN:NBNurn:nbn:hr:184:378578
Publication2017
ProjectNumber: 13.06.2.2.63
Title (croatian): Uloga koštanog morfogenetskog proteina - 9 u akutnom i kroničnom oštećenju jetre
Leader: Olga Peloza
Jurisdiction: Croatia
Funding stream: Sveučilište u Rijeci
Document URLhttp://bib.irb.hr/893107
Type of resourceText
Access conditionsInstitutional access
Terms of useLicence In copyright icon
Created on2022-02-16 17:59:23