prikaz prve stranice dokumenta Donor-specific antibodies require preactivated immune system to harm renal transplant
Access restricted to all Croatian higher education institution's students and staff
Scientific paper - Original scientific paper
Donor-specific antibodies require preactivated immune system to harm renal transplant
EBioMedicine, 9 (2016); 366-371. https://doi.org/10.1016/j.ebiom.2016.06.006
Süsal, Caner; ...; ...; ...; ...; ...; ...; ...; ...; Balen, Sanja; Živčić-Ćosić, Stela; ...; ...; ...; ...; ...; ...; ...; ...; ...; ...; ...; ...; Opelz, Gerhard More authors...

Institutional repository: Repository of the University of Rijeka, Faculty of Medicine

Cite this document

Süsal, C., Balen, S., Živčić Ćosić, S. & Opelz, G. (2016). Donor-specific antibodies require preactivated immune system to harm renal transplant. EBioMedicine, 9., 366-371. doi: 10.1016/j.ebiom.2016.06.006

Süsal, Caner, et al. "Donor-specific antibodies require preactivated immune system to harm renal transplant." EBioMedicine, vol. 9, 2016, pp. 366-371. https://doi.org/10.1016/j.ebiom.2016.06.006

Süsal, Caner, Sanja Balen, Stela Živčić Ćosić and Gerhard Opelz. "Donor-specific antibodies require preactivated immune system to harm renal transplant." EBioMedicine 9 (2016): 366-371. https://doi.org/10.1016/j.ebiom.2016.06.006

Süsal, C., et al. (2016) 'Donor-specific antibodies require preactivated immune system to harm renal transplant', EBioMedicine, 9, pp. 366-371. doi: 10.1016/j.ebiom.2016.06.006

Süsal C, Balen S, Živčić Ćosić S, Opelz G. Donor-specific antibodies require preactivated immune system to harm renal transplant. EBioMedicine [Internet]. 2016 [cited 2024 April 27];9:366-371. doi: 10.1016/j.ebiom.2016.06.006

C. Süsal, S. Balen, S. Živčić Ćosić and G. Opelz, "Donor-specific antibodies require preactivated immune system to harm renal transplant", EBioMedicine, vol. 9, pp. 366-371, 2016. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:445418. [Accessed: 27 April 2024]

Metadata
Title (english)Donor-specific antibodies require preactivated immune system to harm renal transplant
AuthorCaner Süsal
Author
...
Author
...
Author
...
Author
...
Author
...
Author
...
Author
...
Author
...
AuthorSanja Balen
MBZ: 236875
AuthorStela Živčić-Ćosić
Author
...
Author
...
Author
...
Author
...
Author
...
Author
...
Author
...
Author
...
Author
...
Author
...
Author
...
Author
...
AuthorGerhard Opelz
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Internal Medicine)
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Clinical Laboratory Diagnostics)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Clinical Immunology
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Internal Medicine
Abstract (english)
Background It is an unresolved issue why some kidney transplant recipients with pretransplant donor-specific HLA antibodies (DSA) show a high transplant failure rate, whereas in other patients DSA do not harm the graft. We investigated whether help from preactivated T-cells might be necessary for DSA to exert a deleterious effect. Methods The impact of pretransplant DSA and immune activation marker soluble CD30 (sCD30) on 3-year graft survival was analyzed in 385 presensitized kidney transplant recipients. Findings A deleterious influence of pretransplant DSA on graft survival was evident only in patients who were positive for the immune activation marker sCD30. In the absence of sCD30 positivity, 3-year graft survival was virtually identical in patients with or without DSA (83·1±3·9% and 84·3±2·8%, P=0·81). A strikingly lower 3-year graft survival rate of 62·1±6·4% was observed in patients who were both sCD30 and DSA positive (HR 2·92, P<0·001). Even in the presence of strong DSA with ≥5, 000 MFI, the 3-year graft survival rate was high if the recipients were sCD30 negative. Interpretation Pretransplant DSA have a significantly deleterious impact on graft survival only in the presence of high pretransplant levels of the activation marker sCD30.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleEBioMedicine
Numberingvol. 9, pp. 366-371
p-ISSN2352-3964
DOIhttps://doi.org/10.1016/j.ebiom.2016.06.006
URN:NBNurn:nbn:hr:184:445418
Publication2016
Document URLhttp://bib.irb.hr/820647
Type of resourceText
Access conditionsRestricted access
Terms of useLicence In copyright icon
Created on2022-02-17 09:27:45