prikaz prve stranice dokumenta Factors associated with significant liver steatosis and fibrosis as assessed by transient elastography in patients with one or more components of the metabolic syndrome
Access restricted to students and staff of home institution
Scientific paper - Original scientific paper
Factors associated with significant liver steatosis and fibrosis as assessed by transient elastography in patients with one or more components of the metabolic syndrome
Journal of diabetes and its complications, 30 (2016), 7; 1347-1353. urn:nbn:hr:184:988283
Mikolašević, Ivana; Milić, Sandra; Orlić, Lidija; Štimac, Davor; Franjić, Neven; Targher, Giovanni

Institutional repository: Repository of the University of Rijeka, Faculty of Medicine

Cite this document

Mikolašević, I., Milić, S., Orlić, L., Štimac, D., Franjić, N. & Targher, G. (2016). Factors associated with significant liver steatosis and fibrosis as assessed by transient elastography in patients with one or more components of the metabolic syndrome. Journal of diabetes and its complications, 30. (7), 1347-1353. Retrieved from https://urn.nsk.hr/urn:nbn:hr:184:988283

Mikolašević, Ivana, et al. "Factors associated with significant liver steatosis and fibrosis as assessed by transient elastography in patients with one or more components of the metabolic syndrome." Journal of diabetes and its complications, vol. 30, no. 7, 2016, pp. 1347-1353. https://urn.nsk.hr/urn:nbn:hr:184:988283

Mikolašević, Ivana, Sandra Milić, Lidija Orlić, Davor Štimac, Neven Franjić and Giovanni Targher. "Factors associated with significant liver steatosis and fibrosis as assessed by transient elastography in patients with one or more components of the metabolic syndrome." Journal of diabetes and its complications 30, no. 7 (2016): 1347-1353. https://urn.nsk.hr/urn:nbn:hr:184:988283

Mikolašević, I., et al. (2016) 'Factors associated with significant liver steatosis and fibrosis as assessed by transient elastography in patients with one or more components of the metabolic syndrome', Journal of diabetes and its complications, 30(7), pp. 1347-1353. Available at: https://urn.nsk.hr/urn:nbn:hr:184:988283 (Accessed 27 November 2024)

Mikolašević I, Milić S, Orlić L, Štimac D, Franjić N, Targher G. Factors associated with significant liver steatosis and fibrosis as assessed by transient elastography in patients with one or more components of the metabolic syndrome. Journal of diabetes and its complications [Internet]. 2016 [cited 2024 November 27];30(7):1347-1353. Available at: https://urn.nsk.hr/urn:nbn:hr:184:988283

I. Mikolašević, S. Milić, L. Orlić, D. Štimac, N. Franjić and G. Targher, "Factors associated with significant liver steatosis and fibrosis as assessed by transient elastography in patients with one or more components of the metabolic syndrome", Journal of diabetes and its complications, vol. 30, no. 7, pp. 1347-1353, 2016. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:988283. [Accessed: 27 November 2024]

Metadata
Title (english)Factors associated with significant liver steatosis and fibrosis as assessed by transient elastography in patients with one or more components of the metabolic syndrome
AuthorIvana Mikolašević
AuthorSandra Milić
AuthorLidija Orlić
AuthorDavor Štimac
AuthorNeven Franjić
AuthorGiovanni Targher
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Internal Medicine)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Internal Medicine
Abstract (english)
Background/Aims: We examined the relationship between controlled attenuation parameter (CAP) and liver stiffness measurements (LSM), as assessed by transient elastography (TE), and different clinical and biochemical parameters in patients with one or more components of the metabolic syndrome (MetS). The hypothesis of the study was that LSM and CAP values correlate with the number of MetS components. Methods: In this cross-sectional study a total of 648 consecutive patients were recruited during the years 2013-2015. Significant liver steatosis was defined as a CAP value≥238 dB/m, whereas significant fibrosis was defined as a LSM value>7.0 kPa. Results: The prevalence of patients with CAP≥238 dB/m and LSM>7.0 kPa were 88.3% and 16.5%, respectively. Patients with CAP≥238 dB/m (n=572) had a markedly higher prevalence of the MetS and all its individual components, as well as higher levels of serum liver enzymes and uric acid compared with those with normal CAP. Moreover, CAP measurements increased progressively with the number of MetS components. Similarly, among patients with CAP≥238 dB/m, those with LSM>7.0 kPa (n=103) had higher serum liver enzymes and a greater prevalence of the MetS and its individual components than those with LSM≤7.0 kPa. In multivariable regression analysis the factors independently associated with elevated CAP were the presence of the MetS (or its individual components), insulin resistance (defined by HOMA-IR score), increased serum uric acid and LSM>7 kPa. Similarly, the MetS (or its individual components), insulin resistance and increased serum uric acid levels were also independently associated with LSM>7.0 kPa. Conclusions: Patients with one or more MetS components have a high prevalence of NAFLD and advanced liver fibrosis. LSM and CAP correlate with the number of MetS components.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleJournal of diabetes and its complications
Numberingvol. 30, no. 7, pp. 1347-1353
p-ISSN1056-8727
URN:NBNurn:nbn:hr:184:988283
Publication2016
Document URLhttp://bib.irb.hr/815883
Type of resourceText
Access conditionsInstitutional access
Terms of useLicence In copyright icon
Created on2022-02-18 14:24:05