prikaz prve stranice dokumenta Evolving notions on immune response in colorectal cancer and their implications for biomarker development
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Scientific paper - Review paper
Evolving notions on immune response in colorectal cancer and their implications for biomarker development
Inflammation Research, 67 (2018), 5; 375-389. https://doi.org/10.1007/s00011-017-1128-1
Grizzi, Fabio; Basso, Gianluca; Borroni, Elena Monica; Cavalleri, Tommaso; Bianchi, Paolo; Štifter, Sanja; Chiriva-Internati, Maurizio; Malesci, Alberto; Laghi, Luigi

Institutional repository: Repository of the University of Rijeka, Faculty of Medicine

Cite this document

Grizzi, F., Basso, G., Borroni, E. M., Cavalleri, T., Bianchi, P., Štifter, S. ... Laghi, L. (2018). Evolving notions on immune response in colorectal cancer and their implications for biomarker development. Inflammation Research, 67. (5), 375-389. doi: 10.1007/s00011-017-1128-1

Grizzi, Fabio, et al. "Evolving notions on immune response in colorectal cancer and their implications for biomarker development." Inflammation Research, vol. 67, no. 5, 2018, pp. 375-389. https://doi.org/10.1007/s00011-017-1128-1

Grizzi, Fabio, Gianluca Basso, Elena Monica Borroni, Tommaso Cavalleri, Paolo Bianchi, Sanja Štifter, Maurizio Chiriva Internati, Alberto Malesci and Luigi Laghi. "Evolving notions on immune response in colorectal cancer and their implications for biomarker development." Inflammation Research 67, no. 5 (2018): 375-389. https://doi.org/10.1007/s00011-017-1128-1

Grizzi, F., et al. (2018) 'Evolving notions on immune response in colorectal cancer and their implications for biomarker development', Inflammation Research, 67(5), pp. 375-389. doi: 10.1007/s00011-017-1128-1

Grizzi F, Basso G, Borroni EM, Cavalleri T, Bianchi P, Štifter S, and sur.. Evolving notions on immune response in colorectal cancer and their implications for biomarker development. Inflammation Research [Internet]. 2018 [cited 2024 April 19];67(5):375-389. doi: 10.1007/s00011-017-1128-1

F. Grizzi, et al., "Evolving notions on immune response in colorectal cancer and their implications for biomarker development", Inflammation Research, vol. 67, no. 5, pp. 375-389, 2018. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:043788. [Accessed: 19 April 2024]

Metadata
Title (english)Evolving notions on immune response in colorectal cancer and their implications for biomarker development
AuthorFabio Grizzi
AuthorGianluca Basso
AuthorElena Monica Borroni
AuthorTommaso Cavalleri
AuthorPaolo Bianchi
AuthorSanja Štifter
AuthorMaurizio Chiriva-Internati
AuthorAlberto Malesci
AuthorLuigi Laghi
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of General Pathology and Pathological Anatomy)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Pathology
Abstract (english)
Colorectal cancer (CRC) still represents the third most commonly diagnosed type of cancer in men and women worldwide. CRC is acknowledged as a heterogeneous disease that develops through a multi-step sequence of events driven by clonal selections ; this observation is sustained by the fact that histologically similar tumors may have completely different outcomes, including a varied response to therapy. METHODS: In "early" and "intermediate" stage of CRC (stages II and III, respectively) there is a compelling need for new biomarkers fit to assess the metastatic potential of their disease, selecting patients with aggressive disease that might benefit from adjuvant and targeted therapies. Therefore, we review the actual notions on immune response in colorectal cancer and their implications for biomarker development. RESULTS: The recognition of the key role of immune cells in human cancer progression has recently drawn attention on the tumor immune microenvironment, as a source of new indicators of tumor outcome and response to therapy. Thus, beside consolidated histopathological biomarkers, immune endpoints are now emerging as potential biomarkers. CONCLUSIONS: The introduction of immune signatures and cellular and molecular components of the immune system as biomarkers is particularly important considering the increasing use of immune-based cancer therapies as therapeutic strategies for cancer patient
Keywords (english)
Languageenglish
Publication typeScientific paper - Review paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleInflammation Research
Numberingvol. 67, no. 5, pp. 375-389
p-ISSN1023-3830
DOIhttps://doi.org/10.1007/s00011-017-1128-1
URN:NBNurn:nbn:hr:184:043788
Publication2018
Document URLhttp://bib.irb.hr/1049760
Type of resourceText
Access conditionsRestricted access
Terms of useLicence In copyright icon
Created on2022-02-21 09:35:17