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Scientific paper - Original scientific paper
Heat shock protein gp96 and CD4+ and CD8+ T-lymphocytes expression as prognostic factors in various molecular types of invasive breast carcinoma
Neoplasma, 67 (2020), 2; 421-429. https://doi.org/10.4149/neo_2020_190601N478.
Radolović, P.; Grebić, Damir.; Mustać, Elvira; Sebaher, I.; Mamić, J.; Miletić, W.

Institutional repository: Repository of the University of Rijeka, Faculty of Medicine

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Radolović, P., Grebić, D., Mustać, E., Sebaher, I., Mamić, J. & Miletić, W. (2020). Heat shock protein gp96 and CD4+ and CD8+ T-lymphocytes expression as prognostic factors in various molecular types of invasive breast carcinoma. Neoplasma, 67. (2), 421-429. doi: 10.4149/neo_2020_190601N478.

Radolović, P., et al. "Heat shock protein gp96 and CD4+ and CD8+ T-lymphocytes expression as prognostic factors in various molecular types of invasive breast carcinoma." Neoplasma, vol. 67, no. 2, 2020, pp. 421-429. https://doi.org/10.4149/neo_2020_190601N478.

Radolović, P., Damir. Grebić, Elvira Mustać, I. Sebaher, J. Mamić and W. Miletić. "Heat shock protein gp96 and CD4+ and CD8+ T-lymphocytes expression as prognostic factors in various molecular types of invasive breast carcinoma." Neoplasma 67, no. 2 (2020): 421-429. https://doi.org/10.4149/neo_2020_190601N478.

Radolović, P., et al. (2020) 'Heat shock protein gp96 and CD4+ and CD8+ T-lymphocytes expression as prognostic factors in various molecular types of invasive breast carcinoma', Neoplasma, 67(2), pp. 421-429. doi: 10.4149/neo_2020_190601N478.

Radolović P, Grebić D, Mustać E, Sebaher I, Mamić J, Miletić W. Heat shock protein gp96 and CD4+ and CD8+ T-lymphocytes expression as prognostic factors in various molecular types of invasive breast carcinoma. Neoplasma [Internet]. 2020 [cited 2024 November 07];67(2):421-429. doi: 10.4149/neo_2020_190601N478.

P. Radolović, D. Grebić, E. Mustać, I. Sebaher, J. Mamić and W. Miletić, "Heat shock protein gp96 and CD4+ and CD8+ T-lymphocytes expression as prognostic factors in various molecular types of invasive breast carcinoma", Neoplasma, vol. 67, no. 2, pp. 421-429, 2020. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:682023. [Accessed: 07 November 2024]

Metadata
Title (english)Heat shock protein gp96 and CD4+ and CD8+ T-lymphocytes expression as prognostic factors in various molecular types of invasive breast carcinoma
AuthorP. Radolović
AuthorDamir. Grebić
AuthorElvira Mustać
AuthorI. Sebaher
AuthorJ. Mamić
AuthorW. Miletić
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Surgery)
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of General Pathology and Pathological Anatomy)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
Breast carcinoma shows extensive clinical and molecular heterogenicity. Glycoprotein gp96 is considered a negative prognostic and predictive factor. Controversy exists over the prognostic role of tumor lymphocytic infiltrates. The goal of this study is to illustrate differences in gp96 and CD4+ and CD8+ T-lymphocytes expression among all immunohistochemical groups of breast carcinoma in relation to the clinical course and outcome of the disease. A retrospective observational study was conducted through processing and analysis of 152 female patient tissue samples previously classified by immunohistochemistry. After immunohistochemical processing, the samples were microscopically analyzed and positive cells were manually calculated in the entire biopsy sample for each patient. In the group of patients with triple negative carcinoma, a significantly higher number of CD4 positive cells in patients with no local recurrence were proven, as well as a significant correlation between a smaller number of CD4 positive cells with a lethal outcome. In the group of patients with Luminal B HER2+ carcinoma, a significantly higher proportion of CD8+ cells in patients with local recurrence were demonstrated. The highest glycoprotein gp96 expression was demonstrated in the group of patients with triple negative carcinoma, while the lowest in patients with Luminal A and Luminal B HER2– carcinoma. This study has shown significantly higher gp96 expression and higher extent of tumor lymphocytic infiltrate in more malignant types of breast carcinoma and represents a significant contribution in affirmation of the prognostic role of these variables.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleNeoplasma
Numberingvol. 67, no. 2, pp. 421-429
e-ISSN1338-4317
DOIhttps://doi.org/10.4149/neo_2020_190601N478.
URN:NBNurn:nbn:hr:184:682023
Publication2020
Document URLhttp://bib.irb.hr/1056286
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) icon
Created on2022-02-22 08:25:16