prikaz prve stranice dokumenta Genetic variation in the maternal vitamin D receptor FOKI gene as a risk factor for recurrent pregnancy loss
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Scientific paper - Original scientific paper
Genetic variation in the maternal vitamin D receptor FOKI gene as a risk factor for recurrent pregnancy loss
Journal of maternal-fetal & neonatal medicine, 34 (2019), 14; 2221-2226. https://doi.org/10.1080/14767058.2019.1660768.
Barišić, Anita; Pereza, Nina; Hodžić, Alenka; Gašparović Krpina, Milena; Ostojić, Saša; Peterlin, Borut

Institutional repository: Repository of the University of Rijeka, Faculty of Medicine

Cite this document

Barišić, A., Pereza, N., Hodžić, A., Gašparović Krpina, M., Ostojić, S. & Peterlin, B. (2019). Genetic variation in the maternal vitamin D receptor FOKI gene as a risk factor for recurrent pregnancy loss. Journal of maternal-fetal & neonatal medicine, 34. (14), 2221-2226. doi: 10.1080/14767058.2019.1660768.

Barišić, Anita, et al. "Genetic variation in the maternal vitamin D receptor FOKI gene as a risk factor for recurrent pregnancy loss." Journal of maternal-fetal & neonatal medicine, vol. 34, no. 14, 2019, pp. 2221-2226. https://doi.org/10.1080/14767058.2019.1660768.

Barišić, Anita, Nina Pereza, Alenka Hodžić, Milena Gašparović Krpina, Saša Ostojić and Borut Peterlin. "Genetic variation in the maternal vitamin D receptor FOKI gene as a risk factor for recurrent pregnancy loss." Journal of maternal-fetal & neonatal medicine 34, no. 14 (2019): 2221-2226. https://doi.org/10.1080/14767058.2019.1660768.

Barišić, A., et al. (2019) 'Genetic variation in the maternal vitamin D receptor FOKI gene as a risk factor for recurrent pregnancy loss', Journal of maternal-fetal & neonatal medicine, 34(14), pp. 2221-2226. doi: 10.1080/14767058.2019.1660768.

Barišić A, Pereza N, Hodžić A, Gašparović Krpina M, Ostojić S, Peterlin B. Genetic variation in the maternal vitamin D receptor FOKI gene as a risk factor for recurrent pregnancy loss. Journal of maternal-fetal & neonatal medicine [Internet]. 2019 [cited 2024 December 05];34(14):2221-2226. doi: 10.1080/14767058.2019.1660768.

A. Barišić, N. Pereza, A. Hodžić, M. Gašparović Krpina, S. Ostojić and B. Peterlin, "Genetic variation in the maternal vitamin D receptor FOKI gene as a risk factor for recurrent pregnancy loss", Journal of maternal-fetal & neonatal medicine, vol. 34, no. 14, pp. 2221-2226, 2019. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:607550. [Accessed: 05 December 2024]

Metadata
Title (english)Genetic variation in the maternal vitamin D receptor FOKI gene as a risk factor for recurrent pregnancy loss
AuthorAnita Barišić
AuthorNina Pereza
AuthorAlenka Hodžić
AuthorMilena Gašparović Krpina
AuthorSaša Ostojić
AuthorBorut Peterlin
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Biology and Medical Genetics)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Human Genetics, Genomics and Proteomics
Abstract (english)
Purpose: Recurrent pregnancy loss (RPL) is a reproductive disorder defined as the loss of two or more pregnancies before 24 weeks of gestation. Despite the fact that several mechanisms have been previously described for the pathogenesis of RPL, the causes of approximately 50% of cases remain unknown. However, recent studies indicate association of vitamin D deficiency with adverse pregnancy outcome, including RPL. The vitamin D receptor (VDR) is a crucial mediator of the pleiotropic cellular effects of vitamin D. Its function is influenced by several single nucleotide polymorphisms (SNPs). The main objective of the present study was to assess whether maternal VDR SNPs are associated with the risk of RPL in Slovenian and Croatian women. Methods: A case – control study including 320 women with recurrent pregnancy loss and control women was designed to examine the potential association of VDR polymorphisms (FokI rs222857, Cdx2 rs11568820 and Taq1 rs731236) with RPL. Genotyping was performed using polymerase chain reaction and restriction fragment length polymorphism methods. Results: We found a statistically significant higher frequency of the rs222857 CC genotype (X2 = 6.61, p = 0.036) and C allele (X2 = 5.93, p = 0.015) in RPL women compared to controls. Subsequently, the odds for RPL for the rs222857 were increased under the recessive (CCvsCT + TT: OR = 1.78 ; 95% CI = 1.12–2.82 ; p = 0.015) and the codominant (CCvsTT: OR = 2.21 ; 95% CI = 1.08–4.53 ; p = 0.029 ; CCvsCT: OR = 1.68 ; 95% CI = 1.04–2.72 ; p = 0.036) genetic models. The other two analyzed polymorphisms did not show any statistical significant result. Conclusions: Our results suggest that variations in the maternal VDR FokI gene might be associated with RPL in Slovenian and Croatian women.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleJournal of maternal-fetal & neonatal medicine
Numberingvol. 34, no. 14, pp. 2221-2226
p-ISSN1476-7058
DOIhttps://doi.org/10.1080/14767058.2019.1660768.
URN:NBNurn:nbn:hr:184:607550
Publication2019
ProjectNumber: 17.07.2.1.04
Title (croatian): Genska varijabilnost i epigenetički čimbenici u idiopatskim ponavljajućim spontanim pobačajima i spontanom prijevremenom porodu
Leader: Nina Pereza
Jurisdiction: Croatia
Funding stream: Sveučilište u Rijeci
Document URLhttp://bib.irb.hr/1019096
Type of resourceText
Access conditionsRestricted access
Terms of useLicence In copyright icon
Created on2022-02-22 15:49:31