prikaz prve stranice dokumenta Granulysin-mediated apoptosis of trophoblasts in blighted ovum and missed abortion
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Scientific paper - Original scientific paper
Granulysin-mediated apoptosis of trophoblasts in blighted ovum and missed abortion
American Journal of Reproductive Immunology, 80 (2018); 12978. https://doi.org/10.1111/aji.12978
Gulić, Tamara; Laškarin, Gordana; Dominović, Marin; Glavan Gačanin, Lana; Babarović, Emina; Rubeša, Željka; Haller, Herman; Rukavina, Daniel

Institutional repository: Repository of the University of Rijeka, Faculty of Medicine

Cite this document

Gulić, T., Laškarin, G., Dominović, M., Glavan Gačanin, L., Babarović, E., Rubeša, Ž. ... Rukavina, D. (2018). Granulysin-mediated apoptosis of trophoblasts in blighted ovum and missed abortion. American Journal of Reproductive Immunology, 80.. doi: 10.1111/aji.12978

Gulić, Tamara, et al. "Granulysin-mediated apoptosis of trophoblasts in blighted ovum and missed abortion." American Journal of Reproductive Immunology, vol. 80, 2018. https://doi.org/10.1111/aji.12978

Gulić, Tamara, Gordana Laškarin, Marin Dominović, Lana Glavan Gačanin, Emina Babarović, Željka Rubeša, Herman Haller and Daniel Rukavina. "Granulysin-mediated apoptosis of trophoblasts in blighted ovum and missed abortion." American Journal of Reproductive Immunology 80 (2018). https://doi.org/10.1111/aji.12978

Gulić, T., et al. (2018) 'Granulysin-mediated apoptosis of trophoblasts in blighted ovum and missed abortion', American Journal of Reproductive Immunology, 80. doi: 10.1111/aji.12978

Gulić T, Laškarin G, Dominović M, Glavan Gačanin L, Babarović E, Rubeša Ž, and sur.. Granulysin-mediated apoptosis of trophoblasts in blighted ovum and missed abortion. American Journal of Reproductive Immunology [Internet]. 2018 [cited 2024 May 04];80. doi: 10.1111/aji.12978

T. Gulić, et al., "Granulysin-mediated apoptosis of trophoblasts in blighted ovum and missed abortion", American Journal of Reproductive Immunology, vol. 80, 2018. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:094317. [Accessed: 04 May 2024]

Metadata
Title (english)Granulysin-mediated apoptosis of trophoblasts in blighted ovum and missed abortion
AuthorTamara Gulić
AuthorGordana Laškarin
AuthorMarin Dominović
AuthorLana Glavan Gačanin
AuthorEmina Babarović
AuthorŽeljka Rubeša
AuthorHerman Haller
AuthorDaniel Rukavina
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Physiology, Immunology and Pathophxsiology)
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Gynaecology and Obstetrics)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Abstract (english)
Granulysin (GNLY) is a cytotoxic molecule mostly present in decidual natural killer (NK) cells. Blighted ovum (BO) and missed abortion (MA) represent the early pathological pregnancies with hindered development of the embryoblast or a dead embryo. We investigated the GNLY-mediated apoptotic mechanism potentially responsible for delayed termination of pregnancy. METHOD OF STUDY: We performed immunohistological and immunofluorescence labeling of decidual tissues (GNLY, Apaf-1, NF-κB). NKG2A expression was analyzed by flow cytometry and GNLY mRNA by RT- qPCR. RESULTS: The GNLY labeling intensity (H score) was lower in the nuclei of trophoblast cells in BO and MA. GNLY gene levels were inversely detected in BO and MA. A decreased decidual NK cell percentage was found in MA. NK cells from pathological pregnancies expressed lower NKG2A levels. The highest frequency of Apaf-1 was found in trophoblast cells of MA. NF- kB was highly expressed in decidual cells of BO. CONCLUSION: The reduced activation of GNLY- mediated killing might be implicated in the slower rejection of trophoblast cells in BO and MA. A decreased authentic decidual NK cell number could be responsible for low cytotoxicity against trophoblast cells in MA. In BO, trophoblast cells have a higher survival potential due to increased NF-kB expression
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleAmerican Journal of Reproductive Immunology
Numberingvol. 80, 12978
p-ISSN1046-7408
DOIhttps://doi.org/10.1111/aji.12978
URN:NBNurn:nbn:hr:184:094317
Publication2018
ProjectNumber: 13.06.1.1.06
Title (croatian): Imuno-endokrini mehanizmi na majčino-fetalnom spoju tijekom rane trudnoće
Leader: Daniel Rukavina
Jurisdiction: Croatia
Funding stream: Sveučilište u Rijeci
Document URLhttp://bib.irb.hr/1049772
Type of resourceText
Access conditionsRestricted access
Terms of useLicence In copyright icon
Created on2022-02-22 16:30:05