prikaz prve stranice dokumenta Interleukin-17 and Toll-like Receptor 10 genetic polymorphisms and susceptibility to large joint osteoarthritis
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Scientific paper - Original scientific paper
Interleukin-17 and Toll-like Receptor 10 genetic polymorphisms and susceptibility to large joint osteoarthritis
Journal of Orthopaedic Research®, 36 (2017), 6; 1684-1693. https://doi.org/10.1002/jor.23823
Vrgoč, Goran; Vrbanec, Jurica; Eftedal, Randi K.; Dembić, Petra L.; Balen, Sanja; Dembić, Zlatko; Jotanović, Zdravko

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Cite this document

Vrgoč, G., Vrbanec, J., Eftedal, R. K., Dembić, P. L., Balen, S., Dembić, Z. & Jotanović, Z. (2017). Interleukin-17 and Toll-like Receptor 10 genetic polymorphisms and susceptibility to large joint osteoarthritis. Journal of Orthopaedic Research®, 36. (6), 1684-1693. doi: 10.1002/jor.23823

Vrgoč, Goran, et al. "Interleukin-17 and Toll-like Receptor 10 genetic polymorphisms and susceptibility to large joint osteoarthritis." Journal of Orthopaedic Research®, vol. 36, no. 6, 2017, pp. 1684-1693. https://doi.org/10.1002/jor.23823

Vrgoč, Goran, Jurica Vrbanec, Randi K. Eftedal, Petra L. Dembić, Sanja Balen, Zlatko Dembić and Zdravko Jotanović. "Interleukin-17 and Toll-like Receptor 10 genetic polymorphisms and susceptibility to large joint osteoarthritis." Journal of Orthopaedic Research® 36, no. 6 (2017): 1684-1693. https://doi.org/10.1002/jor.23823

Vrgoč, G., et al. (2017) 'Interleukin-17 and Toll-like Receptor 10 genetic polymorphisms and susceptibility to large joint osteoarthritis', Journal of Orthopaedic Research®, 36(6), pp. 1684-1693. doi: 10.1002/jor.23823

Vrgoč G, Vrbanec J, Eftedal RK, Dembić PL, Balen S, Dembić Z, and sur.. Interleukin-17 and Toll-like Receptor 10 genetic polymorphisms and susceptibility to large joint osteoarthritis. Journal of Orthopaedic Research® [Internet]. 2017 [cited 2024 November 23];36(6):1684-1693. doi: 10.1002/jor.23823

G. Vrgoč, et al., "Interleukin-17 and Toll-like Receptor 10 genetic polymorphisms and susceptibility to large joint osteoarthritis", Journal of Orthopaedic Research®, vol. 36, no. 6, pp. 1684-1693, 2017. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:358497. [Accessed: 23 November 2024]

Metadata
Title (english)Interleukin-17 and Toll-like Receptor 10 genetic polymorphisms and susceptibility to large joint osteoarthritis
AuthorGoran Vrgoč
AuthorJurica Vrbanec
AuthorRandi K. Eftedal
AuthorPetra L. Dembić
AuthorSanja Balen
MBZ: 236875
AuthorZlatko Dembić
AuthorZdravko Jotanović
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Clinical Laboratory Diagnostics)
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Orthopedics and Physical Medicine)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
Primary osteoarthritis (OA) is the most common type of a joint disease. It has a polygenic risk inheritance pattern and affects older people. The etiology of this disease is not fully understood. The aim of this study was to investigate the associations between polymorphisms in pro‐ inflammatory interleukin‐17 (IL17A and IL17F) and anti‐inflammatory Toll‐like Receptor 10 (TLR10) genes with the risk for development of advanced stage hip and knee primary OA in the Croatian population. A total of 500 OA patients and 597 controls were genotyped for IL17A SNP (rs2275913), IL17F SNPs (rs763780 and rs1889570), and TLR10 (rs11096957) genes. The allelic and genotypic frequencies of IL17F SNP (rs763780) showed statistically significant differences in comparisons of controls with hip—but not knee—OA patients. The major allele (T) of rs763780 was associated with the lower risk for developing hip OA (p = 7.9 × 10−4, OR = 0.45, 95%CI = 0.27– 0.74), whereas the minor allele (C) was associated with susceptibility to hip OA (p = 7.9 × 10−4, OR = 2.24, 95%CI = 1.35–3.72). The genotype T/T was associated with the protection to hip OA (p = 3.9 × 10−4, OR = 0.41, 95%CI = 0.24–0.70), and, lastly, the genotype T/C was associated with the higher risk to acquiring hip OA (p = 2.6 × 10−4, OR = 2.50, 95%CI = 1.47– 4.25). TLR10 SNP rs11096957 was found significantly associated with predisposition to hip OA (p = 0.04, OR = 1.41, 95%CI = 1.02–1.94) but not knee OA. Our findings suggest that hip OA in Croatian population might have a different genetic risk regarding the IL17 and TLR10 gene locus than knee OA.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleJournal of Orthopaedic Research®
Numberingvol. 36, no. 6, pp. 1684-1693
p-ISSN0736-0266
DOIhttps://doi.org/10.1002/jor.23823
URN:NBNurn:nbn:hr:184:358497
Publication2017
Document URLhttp://bib.irb.hr/1047290
Type of resourceText
Access conditionsRestricted access
Terms of useLicence In copyright icon
Created on2022-02-23 16:24:11