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Scientific paper - Original scientific paper
Is there a relationship between hypomagnesemia and proton-pump inhibitors in patients on chronic hemodialysis?
European Journal of Internal Medicine, 30 (2016); 99-103. https://doi.org/10.1016/j.ejim.2016.01.026
Mikolašević, Ivana; Milić, Sandra; Štimac, Davor; Zaputović, Luka; Lukenda Žanko, Vesna; Gulin, Tonko; Jakopčić, Ivan; Klarić, Dragan; Gulin, Marijana; Orlić, Lidija

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Mikolašević, I., Milić, S., Štimac, D., Zaputović, L., Lukenda Žanko, V., Gulin, T. ... Orlić, L. (2016). Is there a relationship between hypomagnesemia and proton-pump inhibitors in patients on chronic hemodialysis?. European Journal of Internal Medicine, 30., 99-103. doi: 10.1016/j.ejim.2016.01.026

Mikolašević, Ivana, et al. "Is there a relationship between hypomagnesemia and proton-pump inhibitors in patients on chronic hemodialysis?." European Journal of Internal Medicine, vol. 30, 2016, pp. 99-103. https://doi.org/10.1016/j.ejim.2016.01.026

Mikolašević, Ivana, Sandra Milić, Davor Štimac, Luka Zaputović, Vesna Lukenda Žanko, Tonko Gulin, Ivan Jakopčić, Dragan Klarić, Marijana Gulin and Lidija Orlić. "Is there a relationship between hypomagnesemia and proton-pump inhibitors in patients on chronic hemodialysis?." European Journal of Internal Medicine 30 (2016): 99-103. https://doi.org/10.1016/j.ejim.2016.01.026

Mikolašević, I., et al. (2016) 'Is there a relationship between hypomagnesemia and proton-pump inhibitors in patients on chronic hemodialysis?', European Journal of Internal Medicine, 30, pp. 99-103. doi: 10.1016/j.ejim.2016.01.026

Mikolašević I, Milić S, Štimac D, Zaputović L, Lukenda Žanko V, Gulin T, and sur.. Is there a relationship between hypomagnesemia and proton-pump inhibitors in patients on chronic hemodialysis?. European Journal of Internal Medicine [Internet]. 2016 [cited 2024 May 06];30:99-103. doi: 10.1016/j.ejim.2016.01.026

I. Mikolašević, et al., "Is there a relationship between hypomagnesemia and proton-pump inhibitors in patients on chronic hemodialysis?", European Journal of Internal Medicine, vol. 30, pp. 99-103, 2016. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:726964. [Accessed: 06 May 2024]

Metadata
Title (english)Is there a relationship between hypomagnesemia and proton-pump inhibitors in patients on chronic hemodialysis?
AuthorIvana Mikolašević
AuthorSandra Milić
AuthorDavor Štimac
AuthorLuka Zaputović
AuthorVesna Lukenda Žanko
AuthorTonko Gulin
MBZ: 355122
AuthorIvan Jakopčić
AuthorDragan Klarić
AuthorMarijana Gulin
AuthorLidija Orlić
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Internal Medicine)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
We investigated the association among long- term proton-pump inhibitors (PPIs) use with serum magnesium (Mg) levels in chronic hemodialysis (HD) patients, as well as possible association among PPIs use and increased risk of cardiovascular (CVD) morbidity in HD patients. Of 418 HD patients that were screened for inclusion, 136 were excluded due to incomplete medical data, duration of renal replacement therapy (RRT) for less than 12 months, use of Mg-based-phosphate binders or other Mg-based medications or either to presence of chronic increased GI losses. Among 282 patients included in the study, 170 patients were on PPIs. Serum Mg levels were significantly lower among PPI users vs. non-users (0.94±0.2vs.1.03±0.2 mmol/L ; p<0.0001). The median duration of PPIs use was 27±9.6 months (range from 12 to 108) and it was not significantly associated with Mg levels (r=0.116 ; p=0.167). Additionally, residual renal function didn’t show significant correlation with Mg concentration (r=-0.102 ; p=NS) in both groups of patients. The use of PPIs was an independent and strong predictor of low Mg concentrations even in multivariate analysis (OR 3.05 ; 95%Cl 1.2498- 7.4594, p=0.01). On the other hand, the daily dose of PPIs was not associated with low Mg levels. PPIs users had higher rate of adverse CVD events during the one year of follow-up in comparison to non-PPIs users but that difference wasn’t statistically significant (17.6%vs.10.7% ; p=0.110). We have found a significant association between PPIs use and lower serum Mg levels in chronic HD patients.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleEuropean Journal of Internal Medicine
Numberingvol. 30, pp. 99-103
p-ISSN0953-6205
DOIhttps://doi.org/10.1016/j.ejim.2016.01.026
URN:NBNurn:nbn:hr:184:726964
Publication2016
Document URLhttp://bib.irb.hr/797240
Type of resourceText
Access conditionsInstitutional access
Terms of useLicence In copyright icon
Created on2022-02-23 17:29:14