prikaz prve stranice dokumenta Landmarks of endosomal remodeling in early phase of cytomegalovirus infection
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Scientific paper - Original scientific paper
Landmarks of endosomal remodeling in early phase of cytomegalovirus infection
Virology, 515 (2017), 1; 108-122. https://doi.org/10.1016/j.virol.2017.12.001
Karleuša, Ljerka; Mahmutefendić, Hana; Ilić Tomaš, Maja; Blagojević Zagorac, Gordana; Lučin, Pero

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Karleuša, Lj., Mahmutefendić, H., Ilić Tomaš, M., Blagojević Zagorac, G. & Lučin, P. (2017). Landmarks of endosomal remodeling in early phase of cytomegalovirus infection. Virology, 515. (1), 108-122. doi: 10.1016/j.virol.2017.12.001

Karleuša, Ljerka, et al. "Landmarks of endosomal remodeling in early phase of cytomegalovirus infection." Virology, vol. 515, no. 1, 2017, pp. 108-122. https://doi.org/10.1016/j.virol.2017.12.001

Karleuša, Ljerka, Hana Mahmutefendić, Maja Ilić Tomaš, Gordana Blagojević Zagorac and Pero Lučin. "Landmarks of endosomal remodeling in early phase of cytomegalovirus infection." Virology 515, no. 1 (2017): 108-122. https://doi.org/10.1016/j.virol.2017.12.001

Karleuša, Lj., et al. (2017) 'Landmarks of endosomal remodeling in early phase of cytomegalovirus infection', Virology, 515(1), pp. 108-122. doi: 10.1016/j.virol.2017.12.001

Karleuša Lj, Mahmutefendić H, Ilić Tomaš M, Blagojević Zagorac G, Lučin P. Landmarks of endosomal remodeling in early phase of cytomegalovirus infection. Virology [Internet]. 2017 [cited 2024 December 25];515(1):108-122. doi: 10.1016/j.virol.2017.12.001

Lj. Karleuša, H. Mahmutefendić, M. Ilić Tomaš, G. Blagojević Zagorac and P. Lučin, "Landmarks of endosomal remodeling in early phase of cytomegalovirus infection", Virology, vol. 515, no. 1, pp. 108-122, 2017. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:768267. [Accessed: 25 December 2024]

Metadata
Title (english)Landmarks of endosomal remodeling in early phase of cytomegalovirus infection
AuthorLjerka Karleuša
AuthorHana Mahmutefendić
AuthorMaja Ilić Tomaš
AuthorGordana Blagojević Zagorac
AuthorPero Lučin
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Physiology, Immunology and Pathophxsiology)
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Nuclear Medicine)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Abstract (english)
Cytomegaloviruses (CMVs) extensively rearrange the cellular membrane system to develop assembly compartment (AC), but the earliest events in this process are poorly characterized. Here, we demonstrate that murine CMV (MCMV) infection restrains endosomal trafficking of cargo molecules that travel along the recycling (TfR and MHC-I) and the late endosomal (EGFR, M6PR, Lamp1) circuit. Internalized cargo accumulates in Arf6-, Rab5-, Rab22A-, and Rab11-positive and Rab35-, Rab8-, and Rab10-negative juxtanuclear endosomes, suggesting the disruption of Arf/Rab regulatory cascade at the stage of sorting endosomes and the endosomal recycling compartment. Rearrangement of the endosomal system is initiated by an MCMV-encoded function very early in the infection. Our study, thus, establishes a set of landmarks of endosomal remodeling in the early phase of MCMV-infection which coincide with the Golgi rearrangement, suggesting that these perturbations are the earliest membrane reorganizations that may represent an initial step in the biogenesis of the AC.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleVirology
Numberingvol. 515, no. 1, pp. 108-122
p-ISSN0042-6822
DOIhttps://doi.org/10.1016/j.virol.2017.12.001
URN:NBNurn:nbn:hr:184:768267
Publication2017
ProjectNumber: 13.06.1.1.04
Title (croatian): Endosomalni odjeljci u infekciji mišjim citomegalovirusom
Leader: Pero Lučin
Jurisdiction: Croatia
Funding stream: Sveučilište u Rijeci
ProjectNumber: 13.06.2.1.55
Title (croatian): Karakterizacija kasnih endosomalnih odjeljaka i njihova uloga u morfogenezi MCMV-a
Leader: Hana Mahmutefendić Lučin
Jurisdiction: Croatia
Funding stream: Sveučilište u Rijeci
ProjectNumber: 13.06.2.1.56
Title (croatian): Reciklirajući endosomalni putovi
Leader: Gordana Blagojević Zagorac
Jurisdiction: Croatia
Funding stream: Sveučilište u Rijeci
ProjectNumber: IP-2014-09-9564
Title (croatian): Karakterizacija preuređivanja endosomalnih membrana tijekom rane faze infekcije mišjim citomegalovirusom koje vodi k formiranju kompleksa za stvaranje viriona
Title (english): Characterization of endosomal remodelling during the early phase of murine cytomegalovirus infection that leads to the development of the assembly complex
Acronym: AsCo
Leader: Pero Lučin
Jurisdiction: Croatia
Funding stream: IP
Document URLhttp://bib.irb.hr/967287
Type of resourceText
Access conditionsInstitutional access
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Created on2022-02-24 08:35:58