prikaz prve stranice dokumenta Oleanolic acid attenuates cisplatin-induced nephrotoxicity in mice and chemosensitizes human cervical cancer cells to cisplatin cytotoxicity
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Scientific paper - Original scientific paper
Oleanolic acid attenuates cisplatin-induced nephrotoxicity in mice and chemosensitizes human cervical cancer cells to cisplatin cytotoxicity
Food and Chemical Toxicology, 132 (2019); 1-10. https://doi.org/10.1016/j.fct.2019.110676
Potočnjak, Iva; Šimić, Lidija; Vukelić, Iva; Domitrović, Robert

Institutional repository: Repository of the University of Rijeka, Faculty of Medicine

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Potočnjak, I., Šimić, L., Vukelić, I. & Domitrović, R. (2019). Oleanolic acid attenuates cisplatin-induced nephrotoxicity in mice and chemosensitizes human cervical cancer cells to cisplatin cytotoxicity. Food and Chemical Toxicology, 132., 1-10. doi: 10.1016/j.fct.2019.110676

Potočnjak, Iva, et al. "Oleanolic acid attenuates cisplatin-induced nephrotoxicity in mice and chemosensitizes human cervical cancer cells to cisplatin cytotoxicity." Food and Chemical Toxicology, vol. 132, 2019, pp. 1-10. https://doi.org/10.1016/j.fct.2019.110676

Potočnjak, Iva, Lidija Šimić, Iva Vukelić and Robert Domitrović. "Oleanolic acid attenuates cisplatin-induced nephrotoxicity in mice and chemosensitizes human cervical cancer cells to cisplatin cytotoxicity." Food and Chemical Toxicology 132 (2019): 1-10. https://doi.org/10.1016/j.fct.2019.110676

Potočnjak, I., et al. (2019) 'Oleanolic acid attenuates cisplatin-induced nephrotoxicity in mice and chemosensitizes human cervical cancer cells to cisplatin cytotoxicity', Food and Chemical Toxicology, 132, pp. 1-10. doi: 10.1016/j.fct.2019.110676

Potočnjak I, Šimić L, Vukelić I, Domitrović R. Oleanolic acid attenuates cisplatin-induced nephrotoxicity in mice and chemosensitizes human cervical cancer cells to cisplatin cytotoxicity. Food and Chemical Toxicology [Internet]. 2019 October [cited 2024 December 24];132:1-10. doi: 10.1016/j.fct.2019.110676

I. Potočnjak, L. Šimić, I. Vukelić and R. Domitrović, "Oleanolic acid attenuates cisplatin-induced nephrotoxicity in mice and chemosensitizes human cervical cancer cells to cisplatin cytotoxicity", Food and Chemical Toxicology, vol. 132, pp. 1-10, October 2019. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:845369. [Accessed: 24 December 2024]

Metadata
Title (english)Oleanolic acid attenuates cisplatin-induced nephrotoxicity in mice and chemosensitizes human cervical cancer cells to cisplatin cytotoxicity
AuthorIva Potočnjak
AuthorLidija Šimić
AuthorIva Vukelić
AuthorRobert Domitrović
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Chemistry and Biochemistry)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Abstract (english)
Oleanolic acid (OA) is a natural triterpenoid that possesses numerous beneficial health effects such as antioxidant, anti-inflammatory and anti-apoptotic activities. In this study, we investigated the therapeutic effect of OA (10 and 40 mg/kg) on cisplatin (CP)-induced (13 mg/kg) nephrotoxicity. Treatment with OA 40 mg/kg once daily for 2 days, 48 h after CP-intoxication, ameliorated the increased serum markers and histological features of kidney injury. CP administration increased renal expression of antioxidant and anti-inflammatory markers, which was reduced by OA. The increase in proapoptotic caspase-3 and -9 activations, with concomitant increase in poly (ADP-ribose) polymerase (PARP) cleavage, were dose-dependently inhibited by OA. Treatment with OA also ameliorated microtubule-associated protein 1A/1B-light chain 3B (LC3B)-II and autophagy-related protein (Atg) 5 expression induced by CP. The suppression of CP-induced oxidative stress, apoptosis, autophagy and inflammatory response by OA coincided with the inhibition of extracellular-regulated kinase (ERK) 1/2, signal transducer and activator of transcription (STAT) 3 and nuclear factor-kappa B (NF-κB). Interestingly, OA increased CP cytotoxicity in HeLa cervical cancer cells by inducing cytotoxic autophagy. The chemosensitization of HeLa cells to CP suggests a potential beneficial effect of OA in cervical cancer patients due to reduced CP dosage requirements, which requires further investigation.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleFood and Chemical Toxicology
Numberingvol. 132, pp. 1-10
p-ISSN0278-6915
DOIhttps://doi.org/10.1016/j.fct.2019.110676
URN:NBNurn:nbn:hr:184:845369
Publication2019-10
Document URLhttps://linkinghub.elsevier.com/retrieve/pii/S027869151930465X
Type of resourceText
Access conditionsClosed access
Terms of useLicence In copyright icon
Created on2022-02-28 14:57:35