prikaz prve stranice dokumenta Pharmacogenetics of novel oral anticoagulants: a review of identified gene variants & future perspectives
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Scientific paper - Original scientific paper
Pharmacogenetics of novel oral anticoagulants: a review of identified gene variants & future perspectives
Personalized medicine, 15 (2018), 3; 1-13. https://doi.org/10.2217/pme-2017-0092
Ašić, Adna; Marjanović, Damir; Mirat, Jure; Primorac, Dragan

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Ašić, A., Marjanović, D., Mirat, J. & Primorac, D. (2018). Pharmacogenetics of novel oral anticoagulants: a review of identified gene variants & future perspectives. Personalized medicine, 15. (3), 1-13. doi: 10.2217/pme-2017-0092

Ašić, Adna, et al. "Pharmacogenetics of novel oral anticoagulants: a review of identified gene variants & future perspectives." Personalized medicine, vol. 15, no. 3, 2018, pp. 1-13. https://doi.org/10.2217/pme-2017-0092

Ašić, Adna, Damir Marjanović, Jure Mirat and Dragan Primorac. "Pharmacogenetics of novel oral anticoagulants: a review of identified gene variants & future perspectives." Personalized medicine 15, no. 3 (2018): 1-13. https://doi.org/10.2217/pme-2017-0092

Ašić, A., et al. (2018) 'Pharmacogenetics of novel oral anticoagulants: a review of identified gene variants & future perspectives', Personalized medicine, 15(3), pp. 1-13. doi: 10.2217/pme-2017-0092

Ašić A, Marjanović D, Mirat J, Primorac D. Pharmacogenetics of novel oral anticoagulants: a review of identified gene variants & future perspectives. Personalized medicine [Internet]. 2018 [cited 2024 May 18];15(3):1-13. doi: 10.2217/pme-2017-0092

A. Ašić, D. Marjanović, J. Mirat and D. Primorac, "Pharmacogenetics of novel oral anticoagulants: a review of identified gene variants & future perspectives", Personalized medicine, vol. 15, no. 3, pp. 1-13, 2018. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:403873. [Accessed: 18 May 2024]

Metadata
Title (english)Pharmacogenetics of novel oral anticoagulants: a review of identified gene variants & future perspectives
AuthorAdna Ašić
AuthorDamir Marjanović
AuthorJure Mirat
AuthorDragan Primorac
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Biology and Medical Genetics)
Scientific / art field,
discipline and subdiscipline		INTERDISCIPLINARY AREAS OF KNOWLEDGE
Biotechnology in Biomedicine (natural science, biomedicine and healthcare, bioethics area
Abstract (english)
Novel oral anticoagulants (NOACs) are becoming a therapy of choice in everyday clinical practice after almost 50 years during which warfarin and related coumarin derivatives were used as the main anticoagulants. Advantages of NOACs over standard anticoagulants include their predictable pharmacodynamics and pharmacokinetics, stable plasma concentrations and less drug–drug and food–drug interactions. However, pharmacogenetics has its place in administration of NOACs, as considerable interindividual variations have been detected. In this review, previous findings in pharmacogenetics of dabigatran, rivaroxaban, apixaban and edoxaban are summarized, along with recommendations for studying genes encoding metabolically important enzymes for four selected NOACs. Future directions include identification of clinically relevant SNPs, and change in optimum dosage for patients who are carriers of significant variants.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titlePersonalized medicine
Numberingvol. 15, no. 3, pp. 1-13
p-ISSN1741-0541
DOIhttps://doi.org/10.2217/pme-2017-0092
URN:NBNurn:nbn:hr:184:403873
Publication2018
Document URLhttp://bib.irb.hr/945582
Type of resourceText
Access conditionsClosed access
Terms of useLicence In copyright icon
Created on2022-03-02 11:07:32