prikaz prve stranice dokumenta Prospective evaluation of non-alcoholic fatty liver disease by elastographic methods of liver steatosis and fibrosis; controlled attenuation parameter and liver stiffness measurements
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Scientific paper - Original scientific paper
Prospective evaluation of non-alcoholic fatty liver disease by elastographic methods of liver steatosis and fibrosis; controlled attenuation parameter and liver stiffness measurements
Journal of Diabetes and its Complications, 34 (2020), 3; 1-7. https://doi.org/10.1016/j.jdiacomp.2019.107512
Mikolašević, Ivana; Lukenda Žanko, Vesna; Jakopčić, Ivan; Domislović, Viktor; Mijić, Ana; Stevanović, Tajana; Delija, Božena; Bokun, Tomislav; Dinjar Kujundžić, Petra; Ostojić, Ana; Filipec Kanižaj, Tajana; Grgurević, Ivica; Krznarić, Željko.; Štimac, Davor; Targher, G. More authors...

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Mikolašević, I., Lukenda Žanko, V., Jakopčić, I., Domislović, V., Mijić, A., Stevanović, T. ... Targher, G. (2020). Prospective evaluation of non-alcoholic fatty liver disease by elastographic methods of liver steatosis and fibrosis; controlled attenuation parameter and liver stiffness measurements. Journal of Diabetes and its Complications, 34. (3), 1-7. doi: 10.1016/j.jdiacomp.2019.107512

Mikolašević, Ivana, et al. "Prospective evaluation of non-alcoholic fatty liver disease by elastographic methods of liver steatosis and fibrosis; controlled attenuation parameter and liver stiffness measurements." Journal of Diabetes and its Complications, vol. 34, no. 3, 2020, pp. 1-7. https://doi.org/10.1016/j.jdiacomp.2019.107512

Mikolašević, Ivana, Vesna Lukenda Žanko, Ivan Jakopčić, Viktor Domislović, Ana Mijić, Tajana Stevanović, Božena Delija, et al. "Prospective evaluation of non-alcoholic fatty liver disease by elastographic methods of liver steatosis and fibrosis; controlled attenuation parameter and liver stiffness measurements." Journal of Diabetes and its Complications 34, no. 3 (2020): 1-7. https://doi.org/10.1016/j.jdiacomp.2019.107512

Mikolašević, I., et al. (2020) 'Prospective evaluation of non-alcoholic fatty liver disease by elastographic methods of liver steatosis and fibrosis; controlled attenuation parameter and liver stiffness measurements', Journal of Diabetes and its Complications, 34(3), pp. 1-7. doi: 10.1016/j.jdiacomp.2019.107512

Mikolašević I, Lukenda Žanko V, Jakopčić I, Domislović V, Mijić A, Stevanović T, and sur.. Prospective evaluation of non-alcoholic fatty liver disease by elastographic methods of liver steatosis and fibrosis; controlled attenuation parameter and liver stiffness measurements. Journal of Diabetes and its Complications [Internet]. 2020 March [cited 2024 November 04];34(3):1-7. doi: 10.1016/j.jdiacomp.2019.107512

I. Mikolašević, et al., "Prospective evaluation of non-alcoholic fatty liver disease by elastographic methods of liver steatosis and fibrosis; controlled attenuation parameter and liver stiffness measurements", Journal of Diabetes and its Complications, vol. 34, no. 3, pp. 1-7, March 2020. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:263812. [Accessed: 04 November 2024]

Metadata
Title (english)Prospective evaluation of non-alcoholic fatty liver disease by elastographic methods of liver steatosis and fibrosis; controlled attenuation parameter and liver stiffness measurements
AuthorIvana Mikolašević
AuthorVesna Lukenda Žanko
AuthorIvan Jakopčić
AuthorViktor Domislović
AuthorAna Mijić
AuthorTajana Stevanović
AuthorBožena Delija
AuthorTomislav Bokun
AuthorPetra Dinjar Kujundžić
AuthorAna Ostojić
AuthorTajana Filipec Kanižaj
AuthorIvica Grgurević
AuthorŽeljko. Krznarić
AuthorDavor Štimac
AuthorG. Targher
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Internal Medicine)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
Aims: To examine the temporal changes of both controlled attenuation parameter (CAP) and liver stiffness measurements (LSM), assessed by Fibroscan, in a large sample of patients with non-alcoholic fatty liver disease (NAFLD). Methods: In this prospective, observational study, we consecutively enrolled 507 adult individuals with Fibroscan-defined NAFLD who were followed for a mean period of 21.2 ± 11.7 months. Results: During the follow-up period, 84 patients (16.5%) had a progression of CAP of at least 20% with a median time of 39.93 months, while 201 (39.6%) patients had a progression of LSM of at least 20% with median time of 30.46 months. There were significant differences in the proportion of LSM progression across body mass index (BMI) categories, with obese patients having the highest risk of progression over the follow-up (hazard ratio 1.66; 95%CI 1.23-2.25). Multivariable regression analysis showed that BMI and serum creatinine levels were the strongest predictors for CAP progression in the whole population, while HOMA-estimated insulin resistance was an independent predictor of LSM progression over time in the subgroup of obese patients. Conclusion: This prospective study shows for the first time that the progression risk of both liver steatosis and fibrosis, detected non-invasively by Fibroscan, is relevant and shares essentially the same metabolic risk factors that are associated with NAFLD progression detected by other invasive methods.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleJournal of Diabetes and its Complications
Numberingvol. 34, no. 3, pp. 1-7
p-ISSN1056-8727
DOIhttps://doi.org/10.1016/j.jdiacomp.2019.107512
URN:NBNurn:nbn:hr:184:263812
Publication2020-03
Document URLhttps://linkinghub.elsevier.com/retrieve/pii/S1056872719306348
Type of resourceText
Access conditionsInstitutional access
Terms of useLicence In copyright icon
Created on2022-03-03 12:57:21