prikaz prve stranice dokumenta Progressive skin fibrosis is associated with a decline in lung function and worse survival in patients with diffuse cutaneous systemic sclerosis in the European Scleroderma Trials and Research (EUSTAR) cohort
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Scientific paper - Original scientific paper
Progressive skin fibrosis is associated with a decline in lung function and worse survival in patients with diffuse cutaneous systemic sclerosis in the European Scleroderma Trials and Research (EUSTAR) cohort
Annals of the Rheumatic Diseases, 78 (2019), 5; 648-656. https://doi.org/10.1136/annrheumdis-2018-213455
(EUSTAR Collaboration) Wu, Wanlong; Jordan, Suzana; Graf, Nicole; de Oliveira Pena, Janethe; Curram, John; Allanore, Yannick; Matucci- Cerinic, Marco; Pope, Janet E.; Denton, Christopher P.; Khanna, Dinesh; Distler, Oliver; ...; Novak, Srđan; ...; Martinović, Duška; ...; Anić, Branimir; Barešić, Marko; Mayer, Miroslav; ... More authors...

Institutional repository: Repository of the University of Rijeka, Faculty of Medicine

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Wu, W., Jordan, S., Graf, N., de Oliveira Pena, J., Curram, J., Allanore, Y. ... Mayer, M. (2019). Progressive skin fibrosis is associated with a decline in lung function and worse survival in patients with diffuse cutaneous systemic sclerosis in the European Scleroderma Trials and Research (EUSTAR) cohort. Annals of the Rheumatic Diseases, 78. (5), 648-656. doi: 10.1136/annrheumdis-2018-213455

Wu, Wanlong, et al. "Progressive skin fibrosis is associated with a decline in lung function and worse survival in patients with diffuse cutaneous systemic sclerosis in the European Scleroderma Trials and Research (EUSTAR) cohort." Annals of the Rheumatic Diseases, vol. 78, no. 5, 2019, pp. 648-656. https://doi.org/10.1136/annrheumdis-2018-213455

Wu, Wanlong, Suzana Jordan, Nicole Graf, Janethe de Oliveira Pena, John Curram, Yannick Allanore, Marco Matucci Cerinic, et al. "Progressive skin fibrosis is associated with a decline in lung function and worse survival in patients with diffuse cutaneous systemic sclerosis in the European Scleroderma Trials and Research (EUSTAR) cohort." Annals of the Rheumatic Diseases 78, no. 5 (2019): 648-656. https://doi.org/10.1136/annrheumdis-2018-213455

Wu, W., et al. (2019) 'Progressive skin fibrosis is associated with a decline in lung function and worse survival in patients with diffuse cutaneous systemic sclerosis in the European Scleroderma Trials and Research (EUSTAR) cohort', Annals of the Rheumatic Diseases, 78(5), pp. 648-656. doi: 10.1136/annrheumdis-2018-213455

Wu W, Jordan S, Graf N, de Oliveira Pena J, Curram J, Allanore Y, and sur.. Progressive skin fibrosis is associated with a decline in lung function and worse survival in patients with diffuse cutaneous systemic sclerosis in the European Scleroderma Trials and Research (EUSTAR) cohort. Annals of the Rheumatic Diseases [Internet]. 2019 [cited 2024 May 07];78(5):648-656. doi: 10.1136/annrheumdis-2018-213455

W. Wu, et al., "Progressive skin fibrosis is associated with a decline in lung function and worse survival in patients with diffuse cutaneous systemic sclerosis in the European Scleroderma Trials and Research (EUSTAR) cohort", Annals of the Rheumatic Diseases, vol. 78, no. 5, pp. 648-656, 2019. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:498344. [Accessed: 07 May 2024]

Metadata
Title (english)Progressive skin fibrosis is associated with a decline in lung function and worse survival in patients with diffuse cutaneous systemic sclerosis in the European Scleroderma Trials and Research (EUSTAR) cohort
AuthorWanlong Wu
AuthorSuzana Jordan
AuthorNicole Graf
AuthorJanethe de Oliveira Pena
AuthorJohn Curram
AuthorYannick Allanore
AuthorMarco Matucci- Cerinic
AuthorJanet E. Pope
AuthorChristopher P. Denton
AuthorDinesh Khanna
AuthorOliver Distler
Author
...
AuthorSrđan Novak
Author
...
AuthorDuška Martinović
Author
...
AuthorBranimir Anić
MBZ: 140514
AuthorMarko Barešić
MBZ: 224326
AuthorMiroslav Mayer
MBZ: 383474
Author
...
CollaborationEUSTAR Collaboration
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Internal Medicine)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
Objectives To determine whether progressive skin fibrosis is associated with visceral organ progression and mortality during follow-up in patients with diffuse cutaneous systemic sclerosis (dcssc). Methods We evaluated patients from the european scleroderma Trials and Research database with dcssc, baseline modified Rodnan skin score (mRss) ≥7, valid mRss at 12±3 months after baseline and ≥1 annual follow-up visit. Progressive skin fibrosis was defined as an increase in mRss >5 and ≥25% from baseline to 12±3 months. Outcomes were pulmonary, cardiovascular and renal progression, and all-cause death. associations between skin progression and outcomes were evaluated by Kaplan-Meier survival analysis and multivariable Cox regression. results Of 1021 included patients, 78 (7.6%) had progressive skin fibrosis (skin progressors). Median follow-up was 3.4 years. survival analyses indicated that skin progressors had a significantly higher probability of FVC decline ≥10% (53.6% vs 34.4% ; p<0.001) and all-cause death (15.4% vs 7.3% ; p=0.003) than non-progressors. These significant associations were also found in subgroup analyses of patients with either low baseline mRss (≤22/51) or short disease duration (≤15 months). in multivariable analyses, skin progression within 1 year was independently associated with FVC decline ≥10% (HR 1.79, 95% Ci 1.20 to 2.65) and allcause death (HR 2.58, 95% Ci 1.31 to 5.09). Conclusions Progressive skin fibrosis within 1 year is associated with decline in lung function and worse survival in dcssc during follow-up. These results confirm mRss as a surrogate marker in dcssc, which will be helpful for cohort enrichment in future trials and risk stratification in clinical practice.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleAnnals of the Rheumatic Diseases
Numberingvol. 78, no. 5, pp. 648-656
p-ISSN0003-4967
e-ISSN1468-2060
DOIhttps://doi.org/10.1136/annrheumdis-2018-213455
URN:NBNurn:nbn:hr:184:498344
Publication2019
Document URLhttp://bib.irb.hr/1048063
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution-NonCommercial 4.0 International (CC BY-NC 4.0) icon
Created on2022-03-03 13:46:48