Potential role of heat-shock protein 70 and 
interleukin-15 in the pathogenesis of threatened 
spontaneous abortions

Gulić, Tamara; Laškarin, Gordana; Dominović, Marin; Glavan Gačanin, Lana; Babarović, Emina; Haller, Herman; Rukavina, Daniel

doi:10.1111/aji.12525

prikaz prve stranice dokumenta Potential role of heat-shock protein 70 and interleukin-15 in the pathogenesis of threatened spontaneous abortions

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Scientific paper - Original scientific paper

Potential role of heat-shock protein 70 and interleukin-15 in the pathogenesis of threatened spontaneous abortions

American Journal of Reproductive Immunology, 76 (2016), 2; 126-136. https://doi.org/10.1111/aji.12525

Gulić, Tamara; Laškarin, Gordana; Dominović, Marin; Glavan Gačanin, Lana; Babarović, Emina; Haller, Herman; Rukavina, Daniel

Institutional repository: Repository of the University of Rijeka, Faculty of Medicine

Cite this document

APA 6th Edition

Gulić, T., Laškarin, G., Dominović, M., Glavan Gačanin, L., Babarović, E., Haller, H. & Rukavina, D. (2016). Potential role of heat-shock protein 70 and interleukin-15 in the pathogenesis of threatened spontaneous abortions. American Journal of Reproductive Immunology, 76. (2), 126-136. doi: 10.1111/aji.12525

MLA 8th Edition

Gulić, Tamara, et al. "Potential role of heat-shock protein 70 and interleukin-15 in the pathogenesis of threatened spontaneous abortions." American Journal of Reproductive Immunology, vol. 76, no. 2, 2016, pp. 126-136. https://doi.org/10.1111/aji.12525

Chicago 17th Edition

Gulić, Tamara, Gordana Laškarin, Marin Dominović, Lana Glavan Gačanin, Emina Babarović, Herman Haller and Daniel Rukavina. "Potential role of heat-shock protein 70 and interleukin-15 in the pathogenesis of threatened spontaneous abortions." American Journal of Reproductive Immunology 76, no. 2 (2016): 126-136. https://doi.org/10.1111/aji.12525

Harvard

Gulić, T., et al. (2016) 'Potential role of heat-shock protein 70 and interleukin-15 in the pathogenesis of threatened spontaneous abortions', American Journal of Reproductive Immunology, 76(2), pp. 126-136. doi: 10.1111/aji.12525

Vancouver

Gulić T, Laškarin G, Dominović M, Glavan Gačanin L, Babarović E, Haller H, and sur.. Potential role of heat-shock protein 70 and interleukin-15 in the pathogenesis of threatened spontaneous abortions. American Journal of Reproductive Immunology [Internet]. 2016 [cited 2024 April 25];76(2):126-136. doi: 10.1111/aji.12525

IEEE

T. Gulić, et al., "Potential role of heat-shock protein 70 and interleukin-15 in the pathogenesis of threatened spontaneous abortions", American Journal of Reproductive Immunology, vol. 76, no. 2, pp. 126-136, 2016. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:609408. [Accessed: 25 April 2024]

Cite this item: https://urn.nsk.hr/urn:nbn:hr:184:609408

Metadata

Title (english)	Potential role of heat-shock protein 70 and interleukin-15 in the pathogenesis of threatened spontaneous abortions
Author	Tamara Gulić
Author	Gordana Laškarin
Author	Marin Dominović
Author	Lana Glavan Gačanin
Author	Emina Babarović
Author	Herman Haller
Author	Daniel Rukavina
Author's institution	University of Rijeka Faculty of Medicine (Department of Physiology, Immunology and Pathophxsiology)
Author's institution	University of Rijeka Faculty of Medicine (Department of Gynaecology and Obstetrics)
Author's institution	University of Rijeka Faculty of Medicine (Department of General Pathology and Pathological Anatomy)
Scientific / art field, discipline and subdiscipline	BIOMEDICINE AND HEALTHCARE Basic Medical Sciences
Scientific / art field, discipline and subdiscipline	BIOMEDICINE AND HEALTHCARE Clinical Medical Sciences
Abstract (english)	The role of HSP70 and both its constitutive (Hsc) and inducible (Hsp) forms in the pathogenesis of threatened spontaneous abortions was investigated. Immunohistology and/or immunofluorescence was used to analyze paraffin- embedded tissue sections, and reverse transcriptase-quantitative polymerase chain reaction and flow cytometry were used for analyses of decidual mononuclear cells (DMCs) and confocal microscopy for the detection of perforin, granulysin, and lysosome-associated membrane protein-1 (LAMP-1) in decidual lymphocytes (DLs). The percentage of single Hsp70+, Hsc70+, and IL-15+ cells and mRNA levels of HSP70, CD91, and TLR4 were lower in the decidua basalis in cases of threatened miscarriages compared to that in cases of normal pregnancy. In a suspension of normal DMCs, IL-15 significantly decreased the HSP70 members and TLR4 in dendritic cells, T cells, and NK cells while increasing CD91 in NK cells alone. Downregulation of Hsc70, Hsp70, and IL-15 expression at gene and/or protein levels might support the retention of fertilization products in cases of missed abortion and blighted ovum.
Keywords (english)
Language	english
Publication type	Scientific paper - Original scientific paper
Publication status	Published
Peer review	Peer review - international
Publication version	Published version
Journal title	American Journal of Reproductive Immunology
Numbering	vol. 76, no. 2, pp. 126-136
p-ISSN	1046-7408
e-ISSN	1600-0897
DOI	https://doi.org/10.1111/aji.12525
URN:NBN	urn:nbn:hr:184:609408
Publication	2016
Project	Number: 062-0620402-0376 Title (croatian): Citokini i citolitički mehanizmi tijekom rane trudnoće Title (english): Cytokines and cytolytic mechanisms in early pregnancy Leader: Daniel Rukavina Jurisdiction: Croatia Funding stream: ZP
Document URL	http://bib.irb.hr/883090
Type of resource	Text
Access conditions	Restricted access
Terms of use
Created on	2022-03-03 14:24:54

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