prikaz prve stranice dokumenta RANKL/RANK/OPG Axis Is Deregulated in the Cerebrospinal Fluid of Multiple Sclerosis Patients at Clinical Onset
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Scientific paper - Original scientific paper
RANKL/RANK/OPG Axis Is Deregulated in the Cerebrospinal Fluid of Multiple Sclerosis Patients at Clinical Onset
Neuroimmunomodulation, 25 (2018), 1; 23-33. https://doi.org/10.1159/000488988
Glasnović, Anton; Stojić, Maristela; Dežmalj, Lidija; Tudorić-Đeno, Ivana; Romić, Dominik; Jeleč, Vjekoslav; Vrca, Anđelko; Vuletić, Vladimira; Grčević, Danka

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Cite this document

Glasnović, A., Stojić, M., Dežmalj, L., Tudorić Đeno, I., Romić, D., Jeleč, V. ... Grčević, D. (2018). RANKL/RANK/OPG Axis Is Deregulated in the Cerebrospinal Fluid of Multiple Sclerosis Patients at Clinical Onset. Neuroimmunomodulation, 25. (1), 23-33. doi: 10.1159/000488988

Glasnović, Anton, et al. "RANKL/RANK/OPG Axis Is Deregulated in the Cerebrospinal Fluid of Multiple Sclerosis Patients at Clinical Onset." Neuroimmunomodulation, vol. 25, no. 1, 2018, pp. 23-33. https://doi.org/10.1159/000488988

Glasnović, Anton, Maristela Stojić, Lidija Dežmalj, Ivana Tudorić Đeno, Dominik Romić, Vjekoslav Jeleč, Anđelko Vrca, Vladimira Vuletić and Danka Grčević. "RANKL/RANK/OPG Axis Is Deregulated in the Cerebrospinal Fluid of Multiple Sclerosis Patients at Clinical Onset." Neuroimmunomodulation 25, no. 1 (2018): 23-33. https://doi.org/10.1159/000488988

Glasnović, A., et al. (2018) 'RANKL/RANK/OPG Axis Is Deregulated in the Cerebrospinal Fluid of Multiple Sclerosis Patients at Clinical Onset', Neuroimmunomodulation, 25(1), pp. 23-33. doi: 10.1159/000488988

Glasnović A, Stojić M, Dežmalj L, Tudorić Đeno I, Romić D, Jeleč V, and sur.. RANKL/RANK/OPG Axis Is Deregulated in the Cerebrospinal Fluid of Multiple Sclerosis Patients at Clinical Onset. Neuroimmunomodulation [Internet]. 2018 [cited 2024 December 27];25(1):23-33. doi: 10.1159/000488988

A. Glasnović, et al., "RANKL/RANK/OPG Axis Is Deregulated in the Cerebrospinal Fluid of Multiple Sclerosis Patients at Clinical Onset", Neuroimmunomodulation, vol. 25, no. 1, pp. 23-33, 2018. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:043530. [Accessed: 27 December 2024]

Metadata
Title (english)RANKL/RANK/OPG Axis Is Deregulated in the Cerebrospinal Fluid of Multiple Sclerosis Patients at Clinical Onset
AuthorAnton Glasnović
MBZ: 291413
AuthorMaristela Stojić
AuthorLidija Dežmalj
AuthorIvana Tudorić-Đeno
AuthorDominik Romić
AuthorVjekoslav Jeleč
MBZ: 254026
AuthorAnđelko Vrca
MBZ: 100172
AuthorVladimira Vuletić
AuthorDanka Grčević
MBZ: 210400
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Neurology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Neurology
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Immunology
Abstract (english)
OBJECTIVES: Our study focused on the RANKL (receptor activator of nuclear factor-κB ligand)/RANK/OPG (osteoprotegerin) axis and selected proinflammatory/immunoregulatory upstream mediators in the peripheral blood (PBL) and cerebrospinal fluid (CSF) of multiple sclerosis (MS) patients. METHODS: PBL and CSF were collected from healthy controls (n = 35) and MS patients at the clinical onset of the disease (n = 33). In addition, PBL samples were obtained from relapse-remitting (RR)-MS patients (n = 30). Patients were assessed by means of the expanded disability status scale (EDSS) and routine laboratory parameters. Soluble (s)RANKL and OPG were measured in the CSF and plasma ; gene expression was detected for RANKL, RANK, OPG, and selected cytokines/chemokines (interleukin [IL]-4, IL- 10, IL-17, CCL2, and CXCL12) in PBL mononuclear cells. RESULTS: The OPG level in the CSF was lower in MS patients at clinical onset than in controls. Moreover, the sRANKL/OPG ratio was higher in the CSF of MS patients at clinical onset and in the plasma of RR-MS patients than in controls. Gene expression of RANKL/RANK/OPG in PBL mononuclear cells was higher only in RR- MS patients. IL-4, CCL2, and CXCL12 were positively correlated and IL-10 was negatively correlated with RANKL/RANK expression. OPG was negatively correlated with EDSS and alkaline phosphatase level. CONCLUSION: Our study revealed that changes of RANKL/RANK/OPG axis are associated with MS, particularly the decreased OPG level in the CSF at disease onset. Therefore, these factors may serve as disease biomarkers and molecular targets of novel therapeutic approaches.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleNeuroimmunomodulation
Numberingvol. 25, no. 1, pp. 23-33
p-ISSN1021-7401
DOIhttps://doi.org/10.1159/000488988
URN:NBNurn:nbn:hr:184:043530
Publication2018
ProjectNumber: IP-2013-11-5699
Title (croatian): Karakterizacija reakcije osteoklastnih progenitora na artritis
Title (english): Characterization of osteoclast progenitor responses to arthritis
Acronym: COPERA
Leader: Danka Grčević
Jurisdiction: Croatia
Funding stream: IP
Document URLhttp://bib.irb.hr/1007361
Type of resourceText
Access conditionsRestricted access
Terms of useLicence In copyright icon
Created on2022-03-04 12:01:45