prikaz prve stranice dokumenta Role of antibodies in confining cytomegalovirus after reactivation from latency: three decades' resume
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Scientific paper - Review paper
Role of antibodies in confining cytomegalovirus after reactivation from latency: three decades' resume
Medical Microbiology and Immunology, 208 (2019), 3-4; 415-429. https://doi.org/10.1007/s00430-019-00600-1
Krmpotić, Astrid; Podlech, Jürgen; Reddehase, Matthias J.; Britt, William J.; Jonjić, Stipan

Institutional repository: Repository of the University of Rijeka, Faculty of Medicine

Cite this document

Krmpotić, A., Podlech, J., Reddehase, M. J., Britt, W. J. & Jonjić, S. (2019). Role of antibodies in confining cytomegalovirus after reactivation from latency: three decades' resume. Medical Microbiology and Immunology, 208. (3-4), 415-429. doi: 10.1007/s00430-019-00600-1

Krmpotić, Astrid, et al. "Role of antibodies in confining cytomegalovirus after reactivation from latency: three decades' resume." Medical Microbiology and Immunology, vol. 208, no. 3-4, 2019, pp. 415-429. https://doi.org/10.1007/s00430-019-00600-1

Krmpotić, Astrid, Jürgen Podlech, Matthias J. Reddehase, William J. Britt and Stipan Jonjić. "Role of antibodies in confining cytomegalovirus after reactivation from latency: three decades' resume." Medical Microbiology and Immunology 208, no. 3-4 (2019): 415-429. https://doi.org/10.1007/s00430-019-00600-1

Krmpotić, A., et al. (2019) 'Role of antibodies in confining cytomegalovirus after reactivation from latency: three decades' resume', Medical Microbiology and Immunology, 208(3-4), pp. 415-429. doi: 10.1007/s00430-019-00600-1

Krmpotić A, Podlech J, Reddehase MJ, Britt WJ, Jonjić S. Role of antibodies in confining cytomegalovirus after reactivation from latency: three decades' resume. Medical Microbiology and Immunology [Internet]. 2019 [cited 2024 May 14];208(3-4):415-429. doi: 10.1007/s00430-019-00600-1

A. Krmpotić, J. Podlech, M. J. Reddehase, W. J. Britt and S. Jonjić, "Role of antibodies in confining cytomegalovirus after reactivation from latency: three decades' resume", Medical Microbiology and Immunology, vol. 208, no. 3-4, pp. 415-429, 2019. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:665142. [Accessed: 14 May 2024]

Metadata
Title (english)Role of antibodies in confining cytomegalovirus after reactivation from latency: three decades' resume
AuthorAstrid Krmpotić
AuthorJürgen Podlech
AuthorMatthias J. Reddehase
AuthorWilliam J. Britt
AuthorStipan Jonjić
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Histology and Embryology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Abstract (english)
Cytomegaloviruses (CMVs) are highly prevalent herpesviruses, characterized by strict species specificity and the ability to establish non-productive latent infection from which reactivation can occur. Reactivation of latent human CMV (HCMV) represents one of the most important clinical challenges in transplant recipients secondary to the strong immunosuppression. In addition, HCMV is the major viral cause of congenital infection with severe sequelae including brain damage. The accumulated evidence clearly shows that cellular immunity plays a major role in the control of primary CMV infection as well as establishment and maintenance of latency. However, the efficiency of antiviral antibodies in virus control, particularly in prevention of congenital infection and virus reactivation from latency in immunosuppressed hosts, is much less understood. Because of a strict species specificity of HCMV, the role of antibodies in controlling CMV disease has been addressed using murine CMV (MCMV) as a model. Here, we review and discuss the role played by the antiviral antibody response during CMV infections with emphasis on latency and reactivation not only in the MCMV model, but also in relevant clinical settings. We provide evidence to conclude that antiviral antibodies do not prevent the initiating molecular event of virus reactivation from latency but operate by preventing intra-organ spread and inter-organ dissemination of recurrent virus.
Keywords (english)
Languageenglish
Publication typeScientific paper - Review paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleMedical Microbiology and Immunology
Numberingvol. 208, no. 3-4, pp. 415-429
p-ISSN0300-8584
DOIhttps://doi.org/10.1007/s00430-019-00600-1
URN:NBNurn:nbn:hr:184:665142
Publication2019
ProjectNumber: KK.011.1.01.0006
Title (croatian): Jačanje kapaciteta CerVirVac-a za istraživanja u virusnoj imunologiji i vakcinologiji
Leader: Stipan Jonjić
Jurisdiction: Croatia
ProjectNumber: N/A
Title (croatian): Centar izvrsnosti za virusnu imunologiju i cjepiva
Title (english): Centre of Excellence for Research in Viral Immunology and the Development of New Vaccines
Acronym: CERVirVac
Leader: Stipan Jonjić
Jurisdiction: Croatia
Funding stream: ZCI
Document URLhttp://bib.irb.hr/1049584
Type of resourceText
Access conditionsRestricted access
Terms of useLicence In copyright icon
Created on2022-03-08 11:37:21