prikaz prve stranice dokumenta Stevia and stevioside protect against cisplatin nephrotoxicity through inhibition of ERK1/2, STAT3, and NF-κB activation
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Scientific paper - Original scientific paper
Stevia and stevioside protect against cisplatin nephrotoxicity through inhibition of ERK1/2, STAT3, and NF-κB activation
Food and Chemical Toxicology, 107 (2017); 215-225. https://doi.org/10.1016/j.fct.2017.06.043
Potočnjak, Iva; Broznić, Dalibor; Kindl, Marija; Kropek, Matija; Vladimir-Knežević, Sanda; Domitrović, Robert

Institutional repository: Repository of the University of Rijeka, Faculty of Medicine

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Potočnjak, I., Broznić, D., Kindl, M., Kropek, M., Vladimir Knežević, S. & Domitrović, R. (2017). Stevia and stevioside protect against cisplatin nephrotoxicity through inhibition of ERK1/2, STAT3, and NF-κB activation. Food and Chemical Toxicology, 107., 215-225. doi: 10.1016/j.fct.2017.06.043

Potočnjak, Iva, et al. "Stevia and stevioside protect against cisplatin nephrotoxicity through inhibition of ERK1/2, STAT3, and NF-κB activation." Food and Chemical Toxicology, vol. 107, 2017, pp. 215-225. https://doi.org/10.1016/j.fct.2017.06.043

Potočnjak, Iva, Dalibor Broznić, Marija Kindl, Matija Kropek, Sanda Vladimir Knežević and Robert Domitrović. "Stevia and stevioside protect against cisplatin nephrotoxicity through inhibition of ERK1/2, STAT3, and NF-κB activation." Food and Chemical Toxicology 107 (2017): 215-225. https://doi.org/10.1016/j.fct.2017.06.043

Potočnjak, I., et al. (2017) 'Stevia and stevioside protect against cisplatin nephrotoxicity through inhibition of ERK1/2, STAT3, and NF-κB activation', Food and Chemical Toxicology, 107, pp. 215-225. doi: 10.1016/j.fct.2017.06.043

Potočnjak I, Broznić D, Kindl M, Kropek M, Vladimir Knežević S, Domitrović R. Stevia and stevioside protect against cisplatin nephrotoxicity through inhibition of ERK1/2, STAT3, and NF-κB activation. Food and Chemical Toxicology [Internet]. 2017 [cited 2024 December 24];107:215-225. doi: 10.1016/j.fct.2017.06.043

I. Potočnjak, D. Broznić, M. Kindl, M. Kropek, S. Vladimir Knežević and R. Domitrović, "Stevia and stevioside protect against cisplatin nephrotoxicity through inhibition of ERK1/2, STAT3, and NF-κB activation", Food and Chemical Toxicology, vol. 107, pp. 215-225, 2017. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:956629. [Accessed: 24 December 2024]

Metadata
Title (english)Stevia and stevioside protect against cisplatin nephrotoxicity through inhibition of ERK1/2, STAT3, and NF-κB activation
AuthorIva Potočnjak
AuthorDalibor Broznić
AuthorMarija Kindl
MBZ: 327281
AuthorMatija Kropek
AuthorSanda Vladimir-Knežević
MBZ: 170161
AuthorRobert Domitrović
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Chemistry and Biochemistry)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Pharmacy
Abstract (english)
We investigated the effect of natural sweetener Stevia rebaudiana and its constituent stevioside in cisplatin (CP)-induced kidney injury. Male BALB/cN mice were orally administered 10, 20, and 50 mg/kg body weight of Stevia rebaudiana ethanol extract (SE) or stevioside 50 mg/kg, 48 h after intraperitoneal administration of CP (13 mg/kg). Two days later, CP treatment resulted in histopathological changes showing kidney injury. Increased expression of 4-hydroxynonenal (4-HNE), 3-nitrotyrosine (3-NT), and heme oxygenase-1 (HO-1) in mice kidneys suggested oxidative stress. CP treatment also increased renal expression of nuclear factor-kappaB (NF-κB) p65 subunit and phosphorylated inhibitor of NF-κB (IκBα), as well as expression of pro-inflammatory cytokine tumor necrosis factor-alpha (TNF-α). Induction of apoptosis and inhibition of the cell cycle in kidneys was evidenced by increased expression of p53, Bax, caspase-9, and p21, proteolytic cleavage of poly (ADP-ribose) polymerase (PARP), with concomitant suppression of Bcl-2 and cyclin D1 expression. The number of apoptotic cells in kidneys was also assessed. CP administration resulted in activation of extracellular signal-regulated kinases 1 and 2 (ERK1/2) and signal transducer and activator of transcription 3 (STAT3). Both SE and stevioside attenuated CP nephrotoxicity by suppressing oxidative stress, inflammation, and apoptosis through mechanism involving ERK1/2, STAT3, and NF-κB suppression.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleFood and Chemical Toxicology
Numberingvol. 107, pp. 215-225
p-ISSN0278-6915
DOIhttps://doi.org/10.1016/j.fct.2017.06.043
URN:NBNurn:nbn:hr:184:956629
Publication2017
Document URLhttp://bib.irb.hr/877063
Type of resourceText
Access conditionsClosed access
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Created on2022-03-08 14:09:13