prikaz prve stranice dokumenta The Role of CD44 and RHAMM in Endometrial (Endometrioid Type) Cancer: An Immunohistochemical Study
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Scientific paper - Original scientific paper
The Role of CD44 and RHAMM in Endometrial (Endometrioid Type) Cancer: An Immunohistochemical Study
Applied immunohistochemistry & molecular morphology, 27 (2019), 8; 606-612. https://doi.org/10.1097/PAI.0000000000000673.
Klarić, Marko; Haller, Herman; Brnčić Fischer, Alemka; Babarović, Emina; Prijić, Aleksandra; Eminović, Senija

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Klarić, M., Haller, H., Brnčić Fischer, A., Babarović, E., Prijić, A. & Eminović, S. (2019). The Role of CD44 and RHAMM in Endometrial (Endometrioid Type) Cancer: An Immunohistochemical Study. Applied immunohistochemistry & molecular morphology, 27. (8), 606-612. doi: 10.1097/PAI.0000000000000673.

Klarić, Marko, et al. "The Role of CD44 and RHAMM in Endometrial (Endometrioid Type) Cancer: An Immunohistochemical Study." Applied immunohistochemistry & molecular morphology, vol. 27, no. 8, 2019, pp. 606-612. https://doi.org/10.1097/PAI.0000000000000673.

Klarić, Marko, Herman Haller, Alemka Brnčić Fischer, Emina Babarović, Aleksandra Prijić and Senija Eminović. "The Role of CD44 and RHAMM in Endometrial (Endometrioid Type) Cancer: An Immunohistochemical Study." Applied immunohistochemistry & molecular morphology 27, no. 8 (2019): 606-612. https://doi.org/10.1097/PAI.0000000000000673.

Klarić, M., et al. (2019) 'The Role of CD44 and RHAMM in Endometrial (Endometrioid Type) Cancer: An Immunohistochemical Study', Applied immunohistochemistry & molecular morphology, 27(8), pp. 606-612. doi: 10.1097/PAI.0000000000000673.

Klarić M, Haller H, Brnčić Fischer A, Babarović E, Prijić A, Eminović S. The Role of CD44 and RHAMM in Endometrial (Endometrioid Type) Cancer: An Immunohistochemical Study. Applied immunohistochemistry & molecular morphology [Internet]. 2019 [cited 2024 July 13];27(8):606-612. doi: 10.1097/PAI.0000000000000673.

M. Klarić, H. Haller, A. Brnčić Fischer, E. Babarović, A. Prijić and S. Eminović, "The Role of CD44 and RHAMM in Endometrial (Endometrioid Type) Cancer: An Immunohistochemical Study", Applied immunohistochemistry & molecular morphology, vol. 27, no. 8, pp. 606-612, 2019. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:726508. [Accessed: 13 July 2024]

Metadata
Title (english)The Role of CD44 and RHAMM in Endometrial (Endometrioid Type) Cancer: An Immunohistochemical Study
AuthorMarko Klarić
AuthorHerman Haller
AuthorAlemka Brnčić Fischer
AuthorEmina Babarović
AuthorAleksandra Prijić
AuthorSenija Eminović
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Gynaecology and Obstetrics)
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of General Pathology and Pathological Anatomy)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
Hyaluronan controls cell migration, differentiation, and proliferation, and it is involved in tumor invasion. The extracellular matrix containing hyaluronan regulates cell behavior via cell surface receptors such as CD44 and receptor for hyaluronan-mediated motility (RHAMM, CD168). We investigated the expression of CD44 and RHAMM in tissue samples of endometrial cancer and the relation of their expression with clinicopathologic parameters of patients. In order to evaluate the value of CD44 and RHAMM as prognostic factors, we investigated the relation of their expression with patients’ survival. Our results demonstrated a statistically significant correlation with the depth of myometrial invasion, lymphovascular invasion (LVSI), The International Federation of Gynecology and Obstetrics stage of disease, and, in the case of RHAMM expression, a significant correlation with histologic tumor grade as well. CD44 expression was present in the cell membrane in all cases, but in a proportion of tumors in the cytoplasm as well. In this group of patients, we noticed a significantly greater number of cases with deeper myometrial invasion and LVSI. Finally, we sorted out the group of tumors with simultaneous strong CD44 and strong RHAMM expression, and found a statistically significant correlation with the depth of myometrial invasion and LVSI. Using an univariate analysis, we demonstrated that, in our sample of patients, CD44 expression showed a statistically significant influence on patients’ 5-year survival. However, using a multivariate Cox regression analysis, neither CD44 nor RHAMM confirmed themselves as independent prognostic factors.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleApplied immunohistochemistry & molecular morphology
Numberingvol. 27, no. 8, pp. 606-612
p-ISSN1541-2016
DOIhttps://doi.org/10.1097/PAI.0000000000000673.
URN:NBNurn:nbn:hr:184:726508
Publication2019
Document URLhttp://bib.irb.hr/1047298
Type of resourceText
Access conditionsClosed access
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Created on2022-03-11 14:15:31