prikaz prve stranice dokumenta The role of B cells in an early immune response to Mycobacterium bovis
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Scientific paper - Original scientific paper
The role of B cells in an early immune response to Mycobacterium bovis
Microbial Pathogenesis, 140 (2020); 1-10. https://doi.org/10.1016/j.micpath.2019.103937
Krocova, Zuzana; Plzakova, Lenka; Pavkova, Ivona; Kubelkova, Klara; Macela, Ales; Ožanič, Mateja; Marečić, Valentina; Mihelčić, Mirna; Šantić, Marina

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Cite this document

Krocova, Z., Plzakova, L., Pavkova, I., Kubelkova, K., Macela, A., Ožanič, M. ... Šantić, M. (2020). The role of B cells in an early immune response to Mycobacterium bovis. Microbial Pathogenesis, 140., 1-10. doi: 10.1016/j.micpath.2019.103937

Krocova, Zuzana, et al. "The role of B cells in an early immune response to Mycobacterium bovis." Microbial Pathogenesis, vol. 140, 2020, pp. 1-10. https://doi.org/10.1016/j.micpath.2019.103937

Krocova, Zuzana, Lenka Plzakova, Ivona Pavkova, Klara Kubelkova, Ales Macela, Mateja Ožanič, Valentina Marečić, Mirna Mihelčić and Marina Šantić. "The role of B cells in an early immune response to Mycobacterium bovis." Microbial Pathogenesis 140 (2020): 1-10. https://doi.org/10.1016/j.micpath.2019.103937

Krocova, Z., et al. (2020) 'The role of B cells in an early immune response to Mycobacterium bovis', Microbial Pathogenesis, 140, pp. 1-10. doi: 10.1016/j.micpath.2019.103937

Krocova Z, Plzakova L, Pavkova I, Kubelkova K, Macela A, Ožanič M, and sur.. The role of B cells in an early immune response to Mycobacterium bovis. Microbial Pathogenesis [Internet]. 2020 [cited 2024 April 28];140:1-10. doi: 10.1016/j.micpath.2019.103937

Z. Krocova, et al., "The role of B cells in an early immune response to Mycobacterium bovis", Microbial Pathogenesis, vol. 140, pp. 1-10, 2020. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:968723. [Accessed: 28 April 2024]

Metadata
Title (english)The role of B cells in an early immune response to Mycobacterium bovis
AuthorZuzana Krocova
AuthorLenka Plzakova
AuthorIvona Pavkova
AuthorKlara Kubelkova
AuthorAles Macela
AuthorMateja Ožanič
AuthorValentina Marečić
AuthorMirna Mihelčić
AuthorMarina Šantić
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Microbiology and Parasitology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Medical Microbiology
Abstract (english)
Mycobacterium tuberculosis is the main etiological agent of tuberculosis. The Bacillus Calmette-Guérin (BCG) microbes that are primarily used as a vaccine against tuberculosis also constitute the dominant infection model for studying the interaction of mycobacteria with the host cell types. The majority of interaction experiments have been conducted using macrophages and monocytes as prototype phagocyte cell types. Here, we report that M. bovis BCG infects mouse primary B cells as well as human B cell line. The complement receptors, along with B cell receptors, are engaged in the process of bacterial entry into the host B cells. Once inside the B cells, the intracellular trafficking of BCG follows the complete endocytic pathway of the ingested particles, which is in contrast to the events taking place during ingestion of BCG by macrophages. In vivo infection of mice with M. bovis BCG activated peritoneal as well as splenic B cells to produce proinflammatory cytokines. This paper further supports the evidence that B cells are involved in a host's early interactions with intracellular bacterial pathogens and participate in the induction of innate defense responses.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionAccepted version
Journal titleMicrobial Pathogenesis
Numberingvol. 140, pp. 1-10
p-ISSN0882-4010
DOIhttps://doi.org/10.1016/j.micpath.2019.103937
URN:NBNurn:nbn:hr:184:968723
Publication2020
Document URLhttp://bib.irb.hr/1053595
Type of resourceText
Access conditionsRestricted access
Terms of useLicence In copyright icon
Created on2022-03-11 14:35:31