prikaz prve stranice dokumenta Efficacious control of cytomegalovirus infection after long-term depletion of CD8+ T lymphocytes
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Scientific paper - Original scientific paper
Efficacious control of cytomegalovirus infection after long-term depletion of CD8+ T lymphocytes
Journal of Virology, 64 (1990), 11; 5457-5464. https://doi.org/10.1128/jvi.64.11.5457-5464.1990
Jonjić, Stipan; Pavić, Ivica; Lučin, Pero; Rukavina, Danijel; Koszinowski, U H

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Jonjić, S., Pavić, I., Lučin, P., Rukavina, D. & Koszinowski, U. H. (1990). Efficacious control of cytomegalovirus infection after long-term depletion of CD8+ T lymphocytes. Journal of Virology, 64. (11), 5457-5464. doi: 10.1128/jvi.64.11.5457-5464.1990

Jonjić, Stipan, et al. "Efficacious control of cytomegalovirus infection after long-term depletion of CD8+ T lymphocytes." Journal of Virology, vol. 64, no. 11, 1990, pp. 5457-5464. https://doi.org/10.1128/jvi.64.11.5457-5464.1990

Jonjić, Stipan, Ivica Pavić, Pero Lučin, Danijel Rukavina and U H Koszinowski. "Efficacious control of cytomegalovirus infection after long-term depletion of CD8+ T lymphocytes." Journal of Virology 64, no. 11 (1990): 5457-5464. https://doi.org/10.1128/jvi.64.11.5457-5464.1990

Jonjić, S., et al. (1990) 'Efficacious control of cytomegalovirus infection after long-term depletion of CD8+ T lymphocytes', Journal of Virology, 64(11), pp. 5457-5464. doi: 10.1128/jvi.64.11.5457-5464.1990

Jonjić S, Pavić I, Lučin P, Rukavina D, Koszinowski UH. Efficacious control of cytomegalovirus infection after long-term depletion of CD8+ T lymphocytes. Journal of Virology [Internet]. 1990 November [cited 2024 December 28];64(11):5457-5464. doi: 10.1128/jvi.64.11.5457-5464.1990

S. Jonjić, I. Pavić, P. Lučin, D. Rukavina and U. H. Koszinowski, "Efficacious control of cytomegalovirus infection after long-term depletion of CD8+ T lymphocytes", Journal of Virology, vol. 64, no. 11, pp. 5457-5464, November 1990. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:486485. [Accessed: 28 December 2024]

Metadata
Title (english)Efficacious control of cytomegalovirus infection after long-term depletion of CD8+ T lymphocytes
AuthorStipan Jonjić
AuthorIvica Pavić
AuthorPero Lučin
AuthorDanijel Rukavina
AuthorU H Koszinowski
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Physiology, Immunology and Pathophxsiology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Abstract (english)
Although the relative contribution of different immune effector functions to clearing tissues of cytomegalovirus is controversial, the contribution of CD8+ T lymphocytes has generally been accepted as essential. In this report, we show that under certain conditions the CD8+ T-lymphocyte subset can be dispensable for clearance of cytomegalovirus. Mice depleted of the CD8+ T-lymphocyte subset eliminated infectious virus with a clearance kinetics similar to that of normal mice. Adoptive transfer studies revealed that the limitation of virus spread required the cooperation between the CD4+ subset and other cells. Comparison between protective functions generated in fully immunocompetent and in CD8- mice demonstrated that elimination of the CD8+ subset before infection altered the quality of the antiviral immune response. The compensatory protective activity gained by CD4+ cells in CD8- mice was absent in normal mice recovering from virus infection.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleJournal of Virology
Numberingvol. 64, no. 11, pp. 5457-5464
p-ISSN0022-538X
e-ISSN1098-5514
DOIhttps://doi.org/10.1128/jvi.64.11.5457-5464.1990
URN:NBNurn:nbn:hr:184:486485
Publication1990-11
Document URLhttps://journals.asm.org/doi/10.1128/jvi.64.11.5457-5464.1990
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2022-03-17 21:45:16