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Scientific paper - Original scientific paper
Cytokines in Patients with Lung Cancer
Scandinavian Journal of Immunology, 57 (2003), 2; 173-178. https://doi.org/10.1046/j.1365-3083.2003.01205.x
Matanić, Dubravka.; Beg-Zec, Zlata; Stojanović, D.; Matakorić, N.; Flego, Veljko; Milevoj-Ribić, F.

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Matanić, D., Beg Zec, Z., Stojanović, D., Matakorić, N., Flego, V. & Milevoj Ribić, F. (2003). Cytokines in Patients with Lung Cancer. Scandinavian Journal of Immunology, 57. (2), 173-178. doi: 10.1046/j.1365-3083.2003.01205.x

Matanić, Dubravka., et al. "Cytokines in Patients with Lung Cancer." Scandinavian Journal of Immunology, vol. 57, no. 2, 2003, pp. 173-178. https://doi.org/10.1046/j.1365-3083.2003.01205.x

Matanić, Dubravka., Zlata Beg Zec, D. Stojanović, N. Matakorić, Veljko Flego and F. Milevoj Ribić. "Cytokines in Patients with Lung Cancer." Scandinavian Journal of Immunology 57, no. 2 (2003): 173-178. https://doi.org/10.1046/j.1365-3083.2003.01205.x

Matanić, D., et al. (2003) 'Cytokines in Patients with Lung Cancer', Scandinavian Journal of Immunology, 57(2), pp. 173-178. doi: 10.1046/j.1365-3083.2003.01205.x

Matanić D, Beg Zec Z, Stojanović D, Matakorić N, Flego V, Milevoj Ribić F. Cytokines in Patients with Lung Cancer. Scandinavian Journal of Immunology [Internet]. 2003 February [cited 2024 November 26];57(2):173-178. doi: 10.1046/j.1365-3083.2003.01205.x

D. Matanić, Z. Beg Zec, D. Stojanović, N. Matakorić, V. Flego and F. Milevoj Ribić, "Cytokines in Patients with Lung Cancer", Scandinavian Journal of Immunology, vol. 57, no. 2, pp. 173-178, February 2003. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:880908. [Accessed: 26 November 2024]

Metadata
Title (english)Cytokines in Patients with Lung Cancer
AuthorDubravka. Matanić
AuthorZlata Beg-Zec
AuthorD. Stojanović
AuthorN. Matakorić
AuthorVeljko Flego
AuthorF. Milevoj-Ribić
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Internal Medicine)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Internal Medicine
Abstract (english)
Lung cancer is one of the most common malignant diseases and is amongst the leading causes of death. Cell-mediated immune response and cytokines could play an important role in antitumour immunity. The aim of the study was to evaluate the cytokines', tumour necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta) and IL-6, releasing capacity in patients with lung carcinoma and benign lung disease. A group of 41 patients were tested for the production of TNF-alpha, IL-1beta and IL-6 in bronchoalveolar lavage (BAL) and blood. The levels of cytokines in the lung cancer patients were: (1) in BAL - IL-6, 173 +/- 85 pg/ml; TNF-alpha, 170 +/- 116 pg/ml; and IL-1beta, 473 +/- 440 pg/ml; (2) in the blood - IL-6, 197 +/- 53 pg/ml; TNF-alpha, 311 +/- 202 pg/ml; and IL-1beta, 915 +/- 239 pg/ml. Alveolar macrophages of the patients with a lung cancer secreted significantly more cytokines, IL-6 (P = 0.0004) and IL-1beta (P = 0.0047), than alveolar macrophages of the patients with a nonmalignant lung cancer. However, significantly lower levels of cytokine production by the BAL cells were found in patients with small cell lung cancer. This production decreased further in phase IV of nonsmall cell lung cancer.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleScandinavian Journal of Immunology
Numberingvol. 57, no. 2, pp. 173-178
p-ISSN0300-9475
e-ISSN1365-3083
DOIhttps://doi.org/10.1046/j.1365-3083.2003.01205.x
URN:NBNurn:nbn:hr:184:880908
Publication2003-02
Document URLhttp://doi.wiley.com/10.1046/j.1365-3083.2003.01205.x
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2022-03-17 22:16:25