prikaz prve stranice dokumenta Calpain expression in the brain cortex after traumatic brain injury
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Scientific paper - Original scientific paper
Calpain expression in the brain cortex after traumatic brain injury
Collegium antropologicum, 36 (2012), 4; 1319-1323. urn:nbn:hr:184:963591
Bralić, Marina; Stemberga, Valter

Institutional repository: Repository of the University of Rijeka, Faculty of Medicine

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Bralić, M. & Stemberga, V. (2012). Calpain expression in the brain cortex after traumatic brain injury. Collegium antropologicum, 36. (4), 1319-1323. Retrieved from https://urn.nsk.hr/urn:nbn:hr:184:963591

Bralić, Marina and Valter Stemberga. "Calpain expression in the brain cortex after traumatic brain injury." Collegium antropologicum, vol. 36, no. 4, 2012, pp. 1319-1323. https://urn.nsk.hr/urn:nbn:hr:184:963591

Bralić, Marina and Valter Stemberga. "Calpain expression in the brain cortex after traumatic brain injury." Collegium antropologicum 36, no. 4 (2012): 1319-1323. https://urn.nsk.hr/urn:nbn:hr:184:963591

Bralić, M. and Stemberga, V. (2012) 'Calpain expression in the brain cortex after traumatic brain injury', Collegium antropologicum, 36(4), pp. 1319-1323. Available at: https://urn.nsk.hr/urn:nbn:hr:184:963591 (Accessed 23 November 2024)

Bralić M, Stemberga V. Calpain expression in the brain cortex after traumatic brain injury. Collegium antropologicum [Internet]. 2012 [cited 2024 November 23];36(4):1319-1323. Available at: https://urn.nsk.hr/urn:nbn:hr:184:963591

M. Bralić and V. Stemberga, "Calpain expression in the brain cortex after traumatic brain injury", Collegium antropologicum, vol. 36, no. 4, pp. 1319-1323, 2012. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:963591. [Accessed: 23 November 2024]

Metadata
Title (english)Calpain expression in the brain cortex after traumatic brain injury
AuthorMarina Bralić
AuthorValter Stemberga
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Neurology)
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Forensic Medicine and Criminalistics)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Neurology
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Forensic Medicine
Abstract (english)
Traumatic brain injury (TBI) is the leading cause of death and disability worldwide. Calpains, a family of cysteine proteases have been implicated in cells death following TBI. Using immunohistochemistry calpain expression was ana- lyzed in post mortem brain tissue obtained from patients who died after TBI, and findings were compared with the brain tissue from patients who died from sudden cardiac arrest. In the injured cortex an increase in calpain expression was ob- served in all resident brain cells: neurons, glial and endothelial cells in comparison to the control group (all p<0.001). Calpain expression was analyzed in different post- traumatic intervals, from day 0 until 10 days post-injury, in order to establish a time course of expression in the brain cortex after TBI. Expression was detected in the cortex 5 hours after the accident, peaked at 72 hours, and substantially reduced by 10 days after TBI. Calpain expression in the cortex signifi- cantly changed during the time from TBI to death (p<0.001), and the most prominent expression was detected in the cor- tex 3 days after TBI. Our results indicate that prolonged calpain expression in resident brain cells (neurons, glial and en- dothelial cells) plays an important role in neuronal degeneration following TBI.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleCollegium antropologicum
Numberingvol. 36, no. 4, pp. 1319-1323
p-ISSN0350-6134
URN:NBNurn:nbn:hr:184:963591
Publication2012
Document URLhttp://bib.irb.hr/1119393
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) icon
Created on2022-03-17 23:08:13