prikaz prve stranice dokumenta Early and Late Effects of X-Irradiation on Submandibular Gland: A Morphological Study in Mice
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Scientific paper - Original scientific paper
Early and Late Effects of X-Irradiation on Submandibular Gland: A Morphological Study in Mice
Archives of Medical Research, 36 (2005), 4; 339-343. https://doi.org/10.1016/j.arcmed.2005.03.005
Muhvić Urek, Miranda; Bralić, Marina; Tomac, Jelena; Borčić, Josipa; Uhač, Ivone; Glažar, Irena; Antonić, Robert; Ferreri, Silvio

Institutional repository: Repository of the University of Rijeka, Faculty of Medicine

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Muhvić Urek, M., Bralić, M., Tomac, J., Borčić, J., Uhač, I., Glažar, I. ... Ferreri, S. (2005). Early and Late Effects of X-Irradiation on Submandibular Gland: A Morphological Study in Mice. Archives of Medical Research, 36. (4), 339-343. doi: 10.1016/j.arcmed.2005.03.005

Muhvić Urek, Miranda, et al. "Early and Late Effects of X-Irradiation on Submandibular Gland: A Morphological Study in Mice." Archives of Medical Research, vol. 36, no. 4, 2005, pp. 339-343. https://doi.org/10.1016/j.arcmed.2005.03.005

Muhvić Urek, Miranda, Marina Bralić, Jelena Tomac, Josipa Borčić, Ivone Uhač, Irena Glažar, Robert Antonić and Silvio Ferreri. "Early and Late Effects of X-Irradiation on Submandibular Gland: A Morphological Study in Mice." Archives of Medical Research 36, no. 4 (2005): 339-343. https://doi.org/10.1016/j.arcmed.2005.03.005

Muhvić Urek, M., et al. (2005) 'Early and Late Effects of X-Irradiation on Submandibular Gland: A Morphological Study in Mice', Archives of Medical Research, 36(4), pp. 339-343. doi: 10.1016/j.arcmed.2005.03.005

Muhvić Urek M, Bralić M, Tomac J, Borčić J, Uhač I, Glažar I, and sur.. Early and Late Effects of X-Irradiation on Submandibular Gland: A Morphological Study in Mice. Archives of Medical Research [Internet]. 2005 [cited 2024 April 29];36(4):339-343. doi: 10.1016/j.arcmed.2005.03.005

M. Muhvić Urek, et al., "Early and Late Effects of X-Irradiation on Submandibular Gland: A Morphological Study in Mice", Archives of Medical Research, vol. 36, no. 4, pp. 339-343, 2005. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:731180. [Accessed: 29 April 2024]

Metadata
Title (english)Early and Late Effects of X-Irradiation on Submandibular Gland: A Morphological Study in Mice
AuthorMiranda Muhvić Urek
AuthorMarina Bralić
AuthorJelena Tomac
AuthorJosipa Borčić
AuthorIvone Uhač
AuthorIrena Glažar
AuthorRobert Antonić
AuthorSilvio Ferreri
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Histology and Embryology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Abstract (english)
Background: Radiotherapy for head and neck cancers causes permanent salivary gland dysfunction and xerostomia. The aim of this study was to determine changes in mice submandibular glands after X-irradiation. Methods: The submandibular glands of male C57BL/6 mice were locally X-irradiated in the head and neck region with a single dose of 7.5 or 15 Gy and analyzed morphologically and morphometrically at 1, 3, 6, 10, 40, and 90 days after irradiation. Results: Two phases of gland reaction to irradiation have been noted. The first, early phase is observed up to 10 days after irradiation. The second, late phase was observed 90 days after irradiation. Also, a dose-related effect was noticed. The most prominent morphological changes were pyknotic nuclei, vacuolization of acinar cells and lysis of acini and granular convoluted tubules. Changes were detected at 3 and 6 days after irradiation followed by tissue regeneration. Ninety days after irradiation, prominent pathological changes (vacuolization and pyknotic nuclei of acinar cells, lysis of acini and granular convoluted tubules and edema) were detected, but the most remarkable change was disseminated mononuclear infiltration. Also, a statistically significant reduction in number of acinar cells was detected in both irradiated glands. Conclusions: Occurrence of disseminated mononuclear infiltration in gland during late post-irradiation phase makes the mouse model potentially better than the rat model for investigation of irradiation-induced salivary gland damage.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleArchives of Medical Research
Numberingvol. 36, no. 4, pp. 339-343
p-ISSN0188-4409
DOIhttps://doi.org/10.1016/j.arcmed.2005.03.005
URN:NBNurn:nbn:hr:184:731180
Publication2005
Document URLhttps://linkinghub.elsevier.com/retrieve/pii/S0188440905000470
Type of resourceText
Access conditionsClosed access
Terms of useLicence In copyright icon
Created on2022-03-18 14:08:41