prikaz prve stranice dokumenta Altered development of the brain after focal herpesvirus infection of the central nervous system
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Scientific paper - Original scientific paper
Altered development of the brain after focal herpesvirus infection of the central nervous system
Journal of Experimental Medicine, 205 (2008), 2; 423-435. https://doi.org/10.1084/jem.20071489
Koontz, Thad; Bralić, Marina; Tomac, Jelena; Pernjak-Pugel, Ester; Bantug, Glenn Robert; Jonjić, Stipan; Britt, William J.

Institutional repository: Repository of the University of Rijeka, Faculty of Medicine

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Koontz, T., Bralić, M., Tomac, J., Pernjak Pugel, E., Bantug, G. R., Jonjić, S. & Britt, W. J. (2008). Altered development of the brain after focal herpesvirus infection of the central nervous system. Journal of Experimental Medicine, 205. (2), 423-435. doi: 10.1084/jem.20071489

Koontz, Thad, et al. "Altered development of the brain after focal herpesvirus infection of the central nervous system." Journal of Experimental Medicine, vol. 205, no. 2, 2008, pp. 423-435. https://doi.org/10.1084/jem.20071489

Koontz, Thad, Marina Bralić, Jelena Tomac, Ester Pernjak Pugel, Glenn Robert Bantug, Stipan Jonjić and William J. Britt. "Altered development of the brain after focal herpesvirus infection of the central nervous system." Journal of Experimental Medicine 205, no. 2 (2008): 423-435. https://doi.org/10.1084/jem.20071489

Koontz, T., et al. (2008) 'Altered development of the brain after focal herpesvirus infection of the central nervous system', Journal of Experimental Medicine, 205(2), pp. 423-435. doi: 10.1084/jem.20071489

Koontz T, Bralić M, Tomac J, Pernjak Pugel E, Bantug GR, Jonjić S, and sur.. Altered development of the brain after focal herpesvirus infection of the central nervous system. Journal of Experimental Medicine [Internet]. 2008 February 18 [cited 2024 November 23];205(2):423-435. doi: 10.1084/jem.20071489

T. Koontz, et al., "Altered development of the brain after focal herpesvirus infection of the central nervous system", Journal of Experimental Medicine, vol. 205, no. 2, pp. 423-435, February 2008. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:067755. [Accessed: 23 November 2024]

Metadata
Title (english)Altered development of the brain after focal herpesvirus infection of the central nervous system
AuthorThad Koontz
AuthorMarina Bralić
AuthorJelena Tomac
AuthorEster Pernjak-Pugel
AuthorGlenn Robert Bantug
AuthorStipan Jonjić
AuthorWilliam J. Britt
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Histology and Embryology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Abstract (english)
Human cytomegalovirus infection of the developing central nervous system (CNS) is a major cause of neurological damage in newborn infants and children. To investigate the pathogenesis of this human infection, we developed a mouse model of infection in the developing CNS. Intraperitoneal inoculation of newborn animals with murine cytomegalovirus resulted in virus replication in the liver followed by virus spread to the brain. Virus infection of the CNS was associated with the induction of inflammatory responses, including the induction of a large number of interferon-stimulated genes and histological evidence of focal encephalitis with recruitment of mononuclear cells to foci containing virus-infected cells. The morphogenesis of the cerebellum was delayed in infected animals. The defects in cerebellar development in infected animals were generalized and, although correlated temporally with virus replication and CNS inflammation, spatially unrelated to foci of virus-infected cells. Specific defects included decreased granular neuron proliferation and migration, expression of differentiation markers, and activation of neurotrophin receptors. These findings suggested that in the developing CNS, focal virus infection and induction of inflammatory responses in resident and infiltrating mononuclear cells resulted in delayed cerebellar morphogenesis.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleJournal of Experimental Medicine
Numberingvol. 205, no. 2, pp. 423-435
p-ISSN0022-1007
e-ISSN1540-9538
DOIhttps://doi.org/10.1084/jem.20071489
URN:NBNurn:nbn:hr:184:067755
Publication2008-02-18
Document URLhttps://rupress.org/jem/article/205/2/423/40267/Altered-development-of-the-brain-after-focal
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) icon
Created on2022-03-18 14:48:52