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Scientific paper - Review paper
Primjena imunoterapije kod onkoloških bolesnika s COVID-19 – opasnost ili obrana
Medicina Fluminensis, 58 (2022), 1; 55-60. https://doi.org/10.21860/medflum2022_271157
Vučinić, Damir; Marušić, Jasna; Grahovac, Blaženka; Šitum, Mirna; Zamolo, Gordana

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Vučinić, D., Marušić, J., Grahovac, B., Šitum, M. & Zamolo, G. (2022). Primjena imunoterapije kod onkoloških bolesnika s COVID-19 – opasnost ili obrana. Medicina Fluminensis, 58. (1), 55-60. doi: 10.21860/medflum2022_271157

Vučinić, Damir, et al. "Primjena imunoterapije kod onkoloških bolesnika s COVID-19 – opasnost ili obrana." Medicina Fluminensis, vol. 58, no. 1, 2022, pp. 55-60. https://doi.org/10.21860/medflum2022_271157

Vučinić, Damir, Jasna Marušić, Blaženka Grahovac, Mirna Šitum and Gordana Zamolo. "Primjena imunoterapije kod onkoloških bolesnika s COVID-19 – opasnost ili obrana." Medicina Fluminensis 58, no. 1 (2022): 55-60. https://doi.org/10.21860/medflum2022_271157

Vučinić, D., et al. (2022) 'Primjena imunoterapije kod onkoloških bolesnika s COVID-19 – opasnost ili obrana', Medicina Fluminensis, 58(1), pp. 55-60. doi: 10.21860/medflum2022_271157

Vučinić D, Marušić J, Grahovac B, Šitum M, Zamolo G. Primjena imunoterapije kod onkoloških bolesnika s COVID-19 – opasnost ili obrana. Medicina Fluminensis [Internet]. 2022 [cited 2024 December 27];58(1):55-60. doi: 10.21860/medflum2022_271157

D. Vučinić, J. Marušić, B. Grahovac, M. Šitum and G. Zamolo, "Primjena imunoterapije kod onkoloških bolesnika s COVID-19 – opasnost ili obrana", Medicina Fluminensis, vol. 58, no. 1, pp. 55-60, 2022. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:937624. [Accessed: 27 December 2024]

Metadata
Title (croatian)Primjena imunoterapije kod onkoloških bolesnika s COVID-19 – opasnost ili obrana
Title (english)The use of immunotherapy in cancer patient with COVID-19 - threat or protection
AuthorDamir Vučinić https://orcid.org/0000-0002-5804-0799
AuthorJasna Marušić
AuthorBlaženka Grahovac
AuthorMirna Šitum
AuthorGordana Zamolo
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of General Pathology and Pathological Anatomy)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Oncology
Abstract (croatian)
Tijekom pandemije SARS-CoV-2 virusa onkološki pacijenti označeni su kao posebno rizična skupina. Posebnu skupinu čine pacijenti u tijeku imunoterapije inhibitorima kontrolnih točaka. Čini se kako su koristi imunoterapije u bolesti koje uzrokuje novi koronavirus potpuno potisnule početni strah od očekivanih negativnih utjecaja imunosnog sustava potaknutog inhibitorima kontrolnih točaka. Sprječavanjem iscrpljenosti CD8+ limfocita, smanjenjem razine interleukina-6 i indirektnom regulacijom neutrofila i NK stanica, imunoterapija djeluje na patofiziologiju razvoja blažih oblika COVID-19. Trenutne spoznaje ističu imunoterapiju kao sigurnu opciju onkološkog liječenja u doba COVID-19 pandemije.
Abstract (english)
With regard to systemic oncological treatments, correlation of the use of immunotherapy with checkpoint inhibitors with the risk of more severe COVID-19 infection is uncertain. However, benefits of immunotherapy in the disease caused by the new coronavirus completely suppressed the initial fear of expected negative impacts of immune system triggered by checkpoint inhibitors. By preventing CD8 + lymphocyte exhaustion, reducing interleukin-6 levels, and indirectly regulating neutrophils and NK cells, immunotherapy affects the pathophysiology of COVID-19. The current findings highlight immunotherapy as a safe option of cancer treatment at the time of COVID-19 pandemic.
Keywords (croatian)
Keywords (english)
Languagecroatian
Languageenglish
Publication typeScientific paper - Review paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleMedicina Fluminensis
Numberingvol. 58, no. 1, pp. 55-60
p-ISSN1847-6864
e-ISSN1848-820X
DOIhttps://doi.org/10.21860/medflum2022_271157
URN:NBNurn:nbn:hr:184:937624
Publication2022
Document URLhttps://hrcak.srce.hr/271157
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2022-03-18 16:43:33