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Scientific paper - Original scientific paper
The Accuracy of Serum Biomarkers in the Diagnosis of Steatosis, Fibrosis, and Inflammation in Patients with Nonalcoholic Fatty Liver Disease in Comparison to a Liver Biopsy
Medicina, 58 (2022), 2; 252. https://doi.org/10.3390/medicina58020252
Mikolašević, Ivana; Domislović, Viktor; Krznarić-Zrnić, Irena; Krznarić, Željko; Virović-Jukić, Lucija; Stojsavljević, Sanja; Grgurević, Ivica; Milić, Sandra; Vukoja, Ivan; Puž, Petra; Aralica, Merica; Hauser, Goran

Institutional repository: Repository of the University of Rijeka, Faculty of Medicine

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Mikolašević, I., Domislović, V., Krznarić Zrnić, I., Krznarić, Ž., Virović Jukić, L., Stojsavljević, S. ... Hauser, G. (2022). The Accuracy of Serum Biomarkers in the Diagnosis of Steatosis, Fibrosis, and Inflammation in Patients with Nonalcoholic Fatty Liver Disease in Comparison to a Liver Biopsy. Medicina, 58. (2). doi: 10.3390/medicina58020252

Mikolašević, Ivana, et al. "The Accuracy of Serum Biomarkers in the Diagnosis of Steatosis, Fibrosis, and Inflammation in Patients with Nonalcoholic Fatty Liver Disease in Comparison to a Liver Biopsy." Medicina, vol. 58, no. 2, 2022. https://doi.org/10.3390/medicina58020252

Mikolašević, Ivana, Viktor Domislović, Irena Krznarić Zrnić, Željko Krznarić, Lucija Virović Jukić, Sanja Stojsavljević, Ivica Grgurević, et al. "The Accuracy of Serum Biomarkers in the Diagnosis of Steatosis, Fibrosis, and Inflammation in Patients with Nonalcoholic Fatty Liver Disease in Comparison to a Liver Biopsy." Medicina 58, no. 2 (2022). https://doi.org/10.3390/medicina58020252

Mikolašević, I., et al. (2022) 'The Accuracy of Serum Biomarkers in the Diagnosis of Steatosis, Fibrosis, and Inflammation in Patients with Nonalcoholic Fatty Liver Disease in Comparison to a Liver Biopsy', Medicina, 58(2). doi: 10.3390/medicina58020252

Mikolašević I, Domislović V, Krznarić Zrnić I, Krznarić Ž, Virović Jukić L, Stojsavljević S, and sur.. The Accuracy of Serum Biomarkers in the Diagnosis of Steatosis, Fibrosis, and Inflammation in Patients with Nonalcoholic Fatty Liver Disease in Comparison to a Liver Biopsy. Medicina [Internet]. 2022 February 08 [cited 2024 November 07];58(2). doi: 10.3390/medicina58020252

I. Mikolašević, et al., "The Accuracy of Serum Biomarkers in the Diagnosis of Steatosis, Fibrosis, and Inflammation in Patients with Nonalcoholic Fatty Liver Disease in Comparison to a Liver Biopsy", Medicina, vol. 58, no. 2, February 2022. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:905710. [Accessed: 07 November 2024]

Metadata
Title (english)The Accuracy of Serum Biomarkers in the Diagnosis of Steatosis, Fibrosis, and Inflammation in Patients with Nonalcoholic Fatty Liver Disease in Comparison to a Liver Biopsy
AuthorIvana Mikolašević
AuthorViktor Domislović
AuthorIrena Krznarić-Zrnić
AuthorŽeljko Krznarić
AuthorLucija Virović-Jukić
AuthorSanja Stojsavljević
AuthorIvica Grgurević
AuthorSandra Milić
AuthorIvan Vukoja
AuthorPetra Puž
AuthorMerica Aralica
AuthorGoran Hauser
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Internal Medicine)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Internal Medicine
Abstract (english)
Background and Objective: This study was conducted to evaluate the diagnostic performance of various biomarkers for steatosis, fibrosis, and inflammation in comparison to a liver biopsy (LB) in patients with nonalcoholic fatty liver disease (NAFLD). Materials and Methods: This was a cross-sectional study that included 135 patients with biopsy-proven NAFLD. Fatty liver index (FLI), hepatic steatosis index (HSI), cell death markers (CK-18 M30 and CK-18 M65), FIB-4 index, NAFLD fibrosis score (NFS), BARD, and AST to platelet ratio index (APRI) were calculated and analysed. Results: FLI, HSI scores, and the cell death biomarkers showed poor diagnostic accuracy for steatosis detection and quantification, with an area under the curve (AUC) of 0.7) for advanced fibrosis, whereas FIB-4, BARD, and NFS scores demonstrated poor performance (AUC < 0.70). However, a combination of FIB-4 and NFS with the cell death biomarkers had moderate accuracy for advanced (≥F3) fibrosis detection, with an AUC of >0.70. Conclusions: In this first study on Croatian patients with NAFLD, serum biomarkers demonstrated poor diagnostic performance for the noninvasive diagnosis of liver steatosis and NASH. APRI and the cell death biomarkers had only moderate accuracy for diagnosing advanced fibrosis, as did the combination of FIB-4 and NFS with the cell death biomarkers. Further studies regarding serum biomarkers for all NAFLD stages are needed.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleMedicina
Numberingvol. 58, no. 2, 252
e-ISSN1648-9144
DOIhttps://doi.org/10.3390/medicina58020252
URN:NBNurn:nbn:hr:184:905710
Publication2022-02-08
Document URLhttps://www.mdpi.com/1648-9144/58/2/252
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2022-03-21 17:34:07