prikaz prve stranice dokumenta Absence of Oral Opportunistic Infections in Patients with Inflammatory Bowel Disease Receiving Anti-TNF-α and Anti-Integrin-α4β7 Therapy
  Download
PDF 717.03 KB
Scientific paper - Original scientific paper
Absence of Oral Opportunistic Infections in Patients with Inflammatory Bowel Disease Receiving Anti-TNF-α and Anti-Integrin-α4β7 Therapy
Dentistry journal, 10 (2022), 3; 32. urn:nbn:hr:184:696836
Saltović, Ema; Mijandrušić-Sinčić, Brankica; Braut, Alen; Škrobonja, Ivana; Sever, Ella; Glažar, Irena; Pezelj-Ribarić, Sonja; Muhvić- Urek, Miranda

Institutional repository: Repository of the University of Rijeka, Faculty of Medicine

Cite this document

Saltović, E., Mijandrušić Sinčić, B., Braut, A., Škrobonja, I., Sever, E., Glažar, I. ... Muhvić Urek, M. (2022). Absence of Oral Opportunistic Infections in Patients with Inflammatory Bowel Disease Receiving Anti-TNF-α and Anti-Integrin-α4β7 Therapy. Dentistry journal, 10. (3). Retrieved from https://urn.nsk.hr/urn:nbn:hr:184:696836

Saltović, Ema, et al. "Absence of Oral Opportunistic Infections in Patients with Inflammatory Bowel Disease Receiving Anti-TNF-α and Anti-Integrin-α4β7 Therapy." Dentistry journal, vol. 10, no. 3, 2022. https://urn.nsk.hr/urn:nbn:hr:184:696836

Saltović, Ema, Brankica Mijandrušić Sinčić, Alen Braut, Ivana Škrobonja, Ella Sever, Irena Glažar, Sonja Pezelj Ribarić and Miranda Muhvić Urek. "Absence of Oral Opportunistic Infections in Patients with Inflammatory Bowel Disease Receiving Anti-TNF-α and Anti-Integrin-α4β7 Therapy." Dentistry journal 10, no. 3 (2022). https://urn.nsk.hr/urn:nbn:hr:184:696836

Saltović, E., et al. (2022) 'Absence of Oral Opportunistic Infections in Patients with Inflammatory Bowel Disease Receiving Anti-TNF-α and Anti-Integrin-α4β7 Therapy', Dentistry journal, 10(3). Available at: https://urn.nsk.hr/urn:nbn:hr:184:696836 (Accessed 29 April 2024)

Saltović E, Mijandrušić Sinčić B, Braut A, Škrobonja I, Sever E, Glažar I, and sur.. Absence of Oral Opportunistic Infections in Patients with Inflammatory Bowel Disease Receiving Anti-TNF-α and Anti-Integrin-α4β7 Therapy. Dentistry journal [Internet]. 2022 [cited 2024 April 29];10(3). Available at: https://urn.nsk.hr/urn:nbn:hr:184:696836

E. Saltović, et al., "Absence of Oral Opportunistic Infections in Patients with Inflammatory Bowel Disease Receiving Anti-TNF-α and Anti-Integrin-α4β7 Therapy", Dentistry journal, vol. 10, no. 3, 2022. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:696836. [Accessed: 29 April 2024]

Metadata
Title (english)Absence of Oral Opportunistic Infections in Patients with Inflammatory Bowel Disease Receiving Anti-TNF-α and Anti-Integrin-α4β7 Therapy
AuthorEma Saltović
AuthorBrankica Mijandrušić-Sinčić
AuthorAlen Braut
AuthorIvana Škrobonja
AuthorElla Sever
AuthorIrena Glažar
AuthorSonja Pezelj-Ribarić
AuthorMiranda Muhvić- Urek
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Endodontics and Restorative Dentistry)
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Internal Medicine)
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Oral Medicine and Periodontology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Dental Medicine
Abstract (english)
Biological therapy of inflammatory bowel disease (IBD) carries an increased risk for the development of opportunistic infections due to immunomodulation. The aim of this study was to determine the prevalence and types of oral infections in IBD patients treated with biological (anti-TNF-α and anti-integrin-α4β7) and conventional medication protocols. The study included 20 IBD patients receiving anti-TNF-α therapy, 20 IBD patients receiving anti-integrin- α4β7 therapy and 20 IBD patients without immunomodulatory therapy. Participants completed questionnaires on medical information, oral lesions and symptoms. For each patient, clinical examination and a salivary flow rate test were performed, followed by a swab of the oral mucosa. The swab samples were cultured to identify Candida spp. and oral bacteria. No bacterial opportunistic infections were detected. Candidiasis was detected in four participants, with no significant difference between groups (p = 0.765). Hyposalivation was most common in the anti-TNF-α group, with a significant difference between groups (p = 0.036). There were no significant differences between groups in self-reported oral mucosal lesions and symptoms (p > 0.05), or in the distribution of oral mucosal lesions (p > 0.05). This study suggests that IBD patients receiving biological therapy are at no greater risk of developing oral opportunistic infections than IBD patients not receiving immunomodulatory therapy.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleDentistry journal
Numberingvol. 10, no. 3, 32
e-ISSN2304-6767
URN:NBNurn:nbn:hr:184:696836
Publication2022
Document URLhttp://bib.irb.hr/1185637
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2022-03-23 08:48:22