prikaz prve stranice dokumenta Vrijednost tumorskog biljega CA-125 u dijagnostici ranog stadija raka jajnika
Access restricted to students and staff of home institution
master's thesis
Vrijednost tumorskog biljega CA-125 u dijagnostici ranog stadija raka jajnika
Rijeka: University of Rijeka, Faculty of Medicine, 2016. urn:nbn:hr:184:300144
Pavić, Karolina
University of Rijeka
Faculty of Medicine
Department of Gynaecology and Obstetrics

Institutional repository: Repository of the University of Rijeka, Faculty of Medicine

Cite this document

Pavić, K. (2016). Vrijednost tumorskog biljega CA-125 u dijagnostici ranog stadija raka jajnika (Master's thesis). Rijeka: University of Rijeka, Faculty of Medicine. Retrieved from https://urn.nsk.hr/urn:nbn:hr:184:300144

Pavić, Karolina. "Vrijednost tumorskog biljega CA-125 u dijagnostici ranog stadija raka jajnika." Master's thesis, University of Rijeka, Faculty of Medicine, 2016. https://urn.nsk.hr/urn:nbn:hr:184:300144

Pavić, Karolina. "Vrijednost tumorskog biljega CA-125 u dijagnostici ranog stadija raka jajnika." Master's thesis, University of Rijeka, Faculty of Medicine, 2016. https://urn.nsk.hr/urn:nbn:hr:184:300144

Pavić, K. (2016). 'Vrijednost tumorskog biljega CA-125 u dijagnostici ranog stadija raka jajnika', Master's thesis, University of Rijeka, Faculty of Medicine, accessed 23 November 2024, https://urn.nsk.hr/urn:nbn:hr:184:300144

Pavić K. Vrijednost tumorskog biljega CA-125 u dijagnostici ranog stadija raka jajnika [Master's thesis]. Rijeka: University of Rijeka, Faculty of Medicine; 2016 [cited 2024 November 23] Available at: https://urn.nsk.hr/urn:nbn:hr:184:300144

K. Pavić, "Vrijednost tumorskog biljega CA-125 u dijagnostici ranog stadija raka jajnika", Master's thesis, University of Rijeka, Faculty of Medicine, Rijeka, 2016. Available at: https://urn.nsk.hr/urn:nbn:hr:184:300144

Metadata
TitleVrijednost tumorskog biljega CA-125 u dijagnostici ranog stadija raka jajnika
AuthorKarolina Pavić
MentorAlemka Brnčić-Fischer (mentor)
Committee memberAleks Finderle (član povjerenstva)
Committee memberTea Štimac (član povjerenstva)
Committee memberMaja Krašević (član povjerenstva)
GranterUniversity of Rijeka
Faculty of Medicine
(Department of Gynaecology and Obstetrics)
Rijeka
Defense date and country2016, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Gynecology and Obstetrics
Abstract
Tumori jajnika su histogenetski i histološki, a posljedično i klinički, vrlo heterogena skupina tumora te i vodeći uzrok smrtnosti među karcinomima ženskoga genitalnog sustava.Još uvijek ne postoji dijagnostička metoda pogodna za screeninig ranog otkrivanja bolesti, u stadiju u kojem postoje veće šanse za uspješno liječenje i preživljenje. Ranije prepoznavanje otežava činjenica da rani stadiji tumori jajnika imaju oskudnu simptomatologiju.Iako nije specifičan isključivo za tumore jajnika, tumorski biljeg Ca 125 za sada je najbolji klinički pouzdan dijagnostički marker za ove malignome.Svrha ovoga rada bila je istražiti može li se tumorski biljeg Ca 125 koristiti u ranoj dijagnostici karcinoma jajnika ili samo kao prognostičko sredstvo tijekom liječenja.Ovim istraživanjem, u trajanju tri godine, obuhvaćene su 74 ispitanice koje su bolovale od ranog stadija raka jajnika. Većina ih je imala epitelni tumor jajnika te je bila u menopauzi, a najveći broj dijagnoza postavljen je laparotomijom. Također, većina ispitanica nije imala pozitivnu obiteljsku anamnezu na rak jajnika. U istraživanju se vide razlike serumskih vrijednosti Ca 125, u I. i II. kliničkom stadiju raka jajnika, prije i poslije učinjenog operativnog zahvata. Iz dobivenih podataka zaključeno je da Ca 125 može poslužiti kao koristan prognostički pokazatelj u praćenju raka jajnika, što se ne može reći i za njegovu ulogu u ranoj dijagnostici ovog tumora. Iako je srednja preoperativna vrijednost tumorskog biljega Ca 125 bila je značajno viša od referentnih vrijednosti, u trećini slučajeva serumska razina ovog biljega nije bila povišena pa dovodi u sumnju dijagnostički značaj onih slučajeva u kojima je serumska razina bila povišena.
Abstract (english)
Ovarian tumors are histogenetically, histologically, and consequently clinically, very various group of tumors and the leading cause of death among tumors of the female genital tract.There is still no diagnostic method suitable for screeninig early disease, in the stage where there is a greater chance of successful treatment and survival. Earlier diagnosis is disabled by the fact that the early stages of ovarian tumors have barely any symptoms.Although tumor marker Ca 125 is not specific for ovarain cancers only, it is for now the best clinically reliable diagnostic marker for this cancer.The purpose of this study was to investigate if the tumor marker Ca 125 can be used for early ovarian cancer diagnosis, or just as a prognostic tool during therapy.This study involved 74 respondents who suffered from early-stage ovarian cancer, in three years period of time. Most of them suffered from epithelial ovarian cancer and were in menopause. Thery were diagnosed by laparotomy. Also, most of the respondents did not have a family history of ovarian cancer. This study showed serum Ca 125 value differences, before and after the surgery. It is concluded that Ca - 125 can be used as a useful prognostic indicator in monitoring ovarian cancer. This statement does not apply to role of Ca - 125 in the early diagnosis of this tumor. Although the mean preoperative value of tumor marker Ca - 125 was significantly higher than the reference value, in the third of cases it was not increased at all. It casts doubt on the diagnostic significance of this marker.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:184:300144
Study programmeTitle: Medicine
Study programme type: university
Study level: integrated undergraduate and graduate
Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
Type of resourceText
File originBorn digital
Access conditionsAccess restricted to students and staff of home institution
Terms of useLicence In copyright icon
Created on2017-01-18 15:27:28