prikaz prve stranice dokumenta Reproductive immunology in viviparous mammals: evolutionary paradox of interactions among immune mechanisms and autologous or allogeneic gametes and semiallogeneic foetuses
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Scientific paper - Review paper
Reproductive immunology in viviparous mammals: evolutionary paradox of interactions among immune mechanisms and autologous or allogeneic gametes and semiallogeneic foetuses
Veterinary quarterly, 40 (2020), 1; 353-383. https://doi.org/10.1080/01652176.2020.1852336
Samardžija, Marko; Lojkić, Martina; Maćešić, Nino; Valpotić, Hrvoje; Butković, Ivan; Šavorić, Juraj; Žura Žaja, Ivona; Leiner, Denis; Đuričić, Dražen; Marković, Franjo; Kočila, Predrag; Vidas, Željko; Gerenčer, Marijan; Kaštelan, Andrija; Milovanović, Aleksandar; Lazarević, Miodrag; Rukavina, Daniel More authors...

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Samardžija, M., Lojkić, M., Maćešić, N., Valpotić, H., Butković, I., Šavorić, J. ... Rukavina, D. (2020). Reproductive immunology in viviparous mammals: evolutionary paradox of interactions among immune mechanisms and autologous or allogeneic gametes and semiallogeneic foetuses. Veterinary quarterly, 40. (1), 353-383. doi: 10.1080/01652176.2020.1852336

Samardžija, Marko, et al. "Reproductive immunology in viviparous mammals: evolutionary paradox of interactions among immune mechanisms and autologous or allogeneic gametes and semiallogeneic foetuses." Veterinary quarterly, vol. 40, no. 1, 2020, pp. 353-383. https://doi.org/10.1080/01652176.2020.1852336

Samardžija, Marko, Martina Lojkić, Nino Maćešić, Hrvoje Valpotić, Ivan Butković, Juraj Šavorić, Ivona Žura Žaja, et al. "Reproductive immunology in viviparous mammals: evolutionary paradox of interactions among immune mechanisms and autologous or allogeneic gametes and semiallogeneic foetuses." Veterinary quarterly 40, no. 1 (2020): 353-383. https://doi.org/10.1080/01652176.2020.1852336

Samardžija, M., et al. (2020) 'Reproductive immunology in viviparous mammals: evolutionary paradox of interactions among immune mechanisms and autologous or allogeneic gametes and semiallogeneic foetuses', Veterinary quarterly, 40(1), pp. 353-383. doi: 10.1080/01652176.2020.1852336

Samardžija M, Lojkić M, Maćešić N, Valpotić H, Butković I, Šavorić J, and sur.. Reproductive immunology in viviparous mammals: evolutionary paradox of interactions among immune mechanisms and autologous or allogeneic gametes and semiallogeneic foetuses. Veterinary quarterly [Internet]. 2020 [cited 2024 November 17];40(1):353-383. doi: 10.1080/01652176.2020.1852336

M. Samardžija, et al., "Reproductive immunology in viviparous mammals: evolutionary paradox of interactions among immune mechanisms and autologous or allogeneic gametes and semiallogeneic foetuses", Veterinary quarterly, vol. 40, no. 1, pp. 353-383, 2020. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:331235. [Accessed: 17 November 2024]

Metadata
Title (english)Reproductive immunology in viviparous mammals: evolutionary paradox of interactions among immune mechanisms and autologous or allogeneic gametes and semiallogeneic foetuses
AuthorMarko Samardžija
MBZ: 256462
AuthorMartina Lojkić
MBZ: 260214
AuthorNino Maćešić
MBZ: 264551
AuthorHrvoje Valpotić
MBZ: 256372
AuthorIvan Butković
MBZ: 353816
AuthorJuraj Šavorić
MBZ: 367930
AuthorIvona Žura Žaja
MBZ: 310603
AuthorDenis Leiner
MBZ: 369434
AuthorDražen Đuričić
MBZ: 299765
AuthorFranjo Marković
MBZ: 246165
AuthorPredrag Kočila
MBZ: 263831
AuthorŽeljko Vidas
MBZ: 345832
AuthorMarijan Gerenčer
MBZ: 58892
AuthorAndrija Kaštelan
MBZ: 20432
AuthorAleksandar Milovanović
AuthorMiodrag Lazarević
AuthorDaniel Rukavina
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Physiology, Immunology and Pathophxsiology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Immunology
Abstract (english)
Literally, reproductive immunology was born in bovine on-farm reproduction where seminal experiments intended for developing methods for embryo transfer in cattle were performed. Actually, these experiments led to two of major concepts and fundamental principles of reproductive immunology using the bovine species as a model for biomedical research, namely the concept of acquired immunological tolerance and the paradox of the semiallogeneic bovine foetus whereby such organism can develop within an immunologically competent host. Peter Medawar, a scientist who together with Frank Macfarlande Burnet shared the 1960 Nobel Prize in physiology or medicine for discovery of acquired immunological tolerance, while studying dizygotic cattle twins, thereby giving birth to reproductive immunology. Also, these findings significantly influenced development of organ transplants and showed that using farm animals as models for studying transplantation immunology had general relevance for mammalian biology and health including those of humans. However, the interest for further research of the fascinating maternal immune influences on pregnancy and perinatal outcomes and of the prevention and treatment of immunologically mediated reproductive disorders in viviparous mammals of veterinary relevance by veterinary immunologists and reproductive clinicians have been very scarce regarding the application of nonspecific immunomodulatory agents for prevention and treatment of subfertility and infertility in pigs and cattle, but still broadening knowledge in this area and hold great potential for improving such therapy in the future. The aim of the current overview is to provide up-to-date information and explaining/translating relevant immunology phenomena into veterinary practice for specialists and scientists/clinicians in reproduction of animals.
Keywords (english)
Languageenglish
Publication typeScientific paper - Review paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleVeterinary quarterly
Numberingvol. 40, no. 1, pp. 353-383
p-ISSN0165-2176
DOIhttps://doi.org/10.1080/01652176.2020.1852336
URN:NBNurn:nbn:hr:184:331235
Publication2020
Document URLhttp://bib.irb.hr/1096120
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution-NonCommercial 4.0 International (CC BY-NC 4.0) icon
Created on2022-03-31 20:42:51