prikaz prve stranice dokumenta Immunobiology of congenital cytomegalovirus infection of the central nervous system—the murine cytomegalovirus model
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Scientific paper - Review paper
Immunobiology of congenital cytomegalovirus infection of the central nervous system—the murine cytomegalovirus model
Cellular & Molecular Immunology, 12 (2014), 2; 180-191. https://doi.org/10.1038/cmi.2014.51
Slavuljica, Irena; Kveštak, Daria; Csaba Huszthy, Peter; Kosmac, Kate; Britt, William J; Jonjić, Stipan

Institutional repository: Repository of the University of Rijeka, Faculty of Medicine

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Slavuljica, I., Kveštak, D., Csaba Huszthy, P., Kosmac, K., Britt, W. J. & Jonjić, S. (2014). Immunobiology of congenital cytomegalovirus infection of the central nervous system—the murine cytomegalovirus model. Cellular & Molecular Immunology, 12. (2), 180-191. doi: 10.1038/cmi.2014.51

Slavuljica, Irena, et al. "Immunobiology of congenital cytomegalovirus infection of the central nervous system—the murine cytomegalovirus model." Cellular & Molecular Immunology, vol. 12, no. 2, 2014, pp. 180-191. https://doi.org/10.1038/cmi.2014.51

Slavuljica, Irena, Daria Kveštak, Peter Csaba Huszthy, Kate Kosmac, William J Britt and Stipan Jonjić. "Immunobiology of congenital cytomegalovirus infection of the central nervous system—the murine cytomegalovirus model." Cellular & Molecular Immunology 12, no. 2 (2014): 180-191. https://doi.org/10.1038/cmi.2014.51

Slavuljica, I., et al. (2014) 'Immunobiology of congenital cytomegalovirus infection of the central nervous system—the murine cytomegalovirus model', Cellular & Molecular Immunology, 12(2), pp. 180-191. doi: 10.1038/cmi.2014.51

Slavuljica I, Kveštak D, Csaba Huszthy P, Kosmac K, Britt WJ, Jonjić S. Immunobiology of congenital cytomegalovirus infection of the central nervous system—the murine cytomegalovirus model. Cellular & Molecular Immunology [Internet]. 2014 [cited 2024 May 14];12(2):180-191. doi: 10.1038/cmi.2014.51

I. Slavuljica, D. Kveštak, P. Csaba Huszthy, K. Kosmac, W. J. Britt and S. Jonjić, "Immunobiology of congenital cytomegalovirus infection of the central nervous system—the murine cytomegalovirus model", Cellular & Molecular Immunology, vol. 12, no. 2, pp. 180-191, 2014. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:378634. [Accessed: 14 May 2024]

Metadata
Title (english)Immunobiology of congenital cytomegalovirus infection of the central nervous system—the murine cytomegalovirus model
AuthorIrena Slavuljica
AuthorDaria Kveštak
AuthorPeter Csaba Huszthy
AuthorKate Kosmac
AuthorWilliam J Britt
AuthorStipan Jonjić
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Histology and Embryology)
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Infectious Diseases)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Abstract (english)
Congenital human cytomegalovirus infection is a leading infectious cause of long-term neurodevelopmental sequelae, including mental retardation and hearing defects. Strict species specificity of cytomegaloviruses has restricted the scope of studies of cytomegalovirus infection in animal models. To investigate the pathogenesis of congenital human cytomegalovirus infection, we developed a mouse cytomegalovirus model that recapitulates the major characteristics of central nervous system infection in human infants, including the route of neuroinvasion and neuropathological findings. Following intraperitoneal inoculation of newborn animals with mouse cytomegalovirus, the virus disseminates to the central nervous system during high-level viremia and replicates in the brain parenchyma, resulting in a focal but widespread, non-necrotizing encephalitis. Central nervous system infection is coupled with the recruitment of resident and peripheral immune cells as well as the expression of a large number of pro-inflammatory cytokines. Although infiltration of cellular constituents of the innate immune response characterizes the early immune response in the central nervous system, resolution of productive infection requires virus-specific CD8(+) T cells. Perinatal mouse cytomegalovirus infection results in profoundly altered postnatal development of the mouse central nervous system and long-term motor and sensory disabilities. Based on an enhanced understanding of the pathogenesis of this infection, prospects for novel intervention strategies aimed to improve the outcome of congenital human cytomegalovirus infection are proposed.
Keywords (english)
Languageenglish
Publication typeScientific paper - Review paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleCellular & Molecular Immunology
Numberingvol. 12, no. 2, pp. 180-191
p-ISSN1672-7681
e-ISSN2042-0226
DOIhttps://doi.org/10.1038/cmi.2014.51
URN:NBNurn:nbn:hr:184:378634
Publication2014
ProjectNumber: 1R01NS065845-01A1
Title (english): MCMV Infection of the Developing CNS: Neuroinvasion and Immune Control
Leader: Stipan Jonjić
Jurisdiction: United States
Funding stream: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
ProjectNumber: 1RO1AI083201-01
Title (english): Viral evasion of NK cells
Leader: Stipan Jonjić
Jurisdiction: United States
Document URLhttp://www.nature.com/articles/cmi201451
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2022-04-08 13:12:10