prikaz prve stranice dokumenta NK/ILC1 cells mediate neuroinflammation and brain pathology following congenital CMV infection
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Scientific paper - Preliminary note / Short communication
NK/ILC1 cells mediate neuroinflammation and brain pathology following congenital CMV infection
Journal of Experimental Medicine, 218 (2021), 5; 1-14. https://doi.org/10.1084/jem.20201503
Kveštak, Daria; Juranić Lisnić, Vanda; Lisnić, Berislav; Tomac, Jelena; Golemac, Mijo; Brizić, Ilija; Indenbirken, Daniela; Cokarić Brdovčak, Maja; Bernardini, Giovanni; Krstanović, Fran; Rožmanić, Carmen; Grundhoff, Adam; Krmpotić, Astrid; Britt, William J.; Jonjić, Stipan More authors...

Institutional repository: Repository of the University of Rijeka, Faculty of Medicine

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Kveštak, D., Juranić Lisnić, V., Lisnić, B., Tomac, J., Golemac, M., Brizić, I. ... Jonjić, S. (2021). NK/ILC1 cells mediate neuroinflammation and brain pathology following congenital CMV infection. Journal of Experimental Medicine, 218. (5), 1-14. doi: 10.1084/jem.20201503

Kveštak, Daria, et al. "NK/ILC1 cells mediate neuroinflammation and brain pathology following congenital CMV infection." Journal of Experimental Medicine, vol. 218, no. 5, 2021, pp. 1-14. https://doi.org/10.1084/jem.20201503

Kveštak, Daria, Vanda Juranić Lisnić, Berislav Lisnić, Jelena Tomac, Mijo Golemac, Ilija Brizić, Daniela Indenbirken, et al. "NK/ILC1 cells mediate neuroinflammation and brain pathology following congenital CMV infection." Journal of Experimental Medicine 218, no. 5 (2021): 1-14. https://doi.org/10.1084/jem.20201503

Kveštak, D., et al. (2021) 'NK/ILC1 cells mediate neuroinflammation and brain pathology following congenital CMV infection', Journal of Experimental Medicine, 218(5), pp. 1-14. doi: 10.1084/jem.20201503

Kveštak D, Juranić Lisnić V, Lisnić B, Tomac J, Golemac M, Brizić I, and sur.. NK/ILC1 cells mediate neuroinflammation and brain pathology following congenital CMV infection. Journal of Experimental Medicine [Internet]. 2021 May 03 [cited 2024 May 14];218(5):1-14. doi: 10.1084/jem.20201503

D. Kveštak, et al., "NK/ILC1 cells mediate neuroinflammation and brain pathology following congenital CMV infection", Journal of Experimental Medicine, vol. 218, no. 5, pp. 1-14, May 2021. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:755338. [Accessed: 14 May 2024]

Metadata
Title (english)NK/ILC1 cells mediate neuroinflammation and brain pathology following congenital CMV infection
AuthorDaria Kveštak
AuthorVanda Juranić Lisnić
AuthorBerislav Lisnić
AuthorJelena Tomac
AuthorMijo Golemac
AuthorIlija Brizić
AuthorDaniela Indenbirken
AuthorMaja Cokarić Brdovčak
AuthorGiovanni Bernardini
AuthorFran Krstanović
AuthorCarmen Rožmanić
AuthorAdam Grundhoff
AuthorAstrid Krmpotić
AuthorWilliam J. Britt
AuthorStipan Jonjić
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Center for Proteomics)
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Histology and Embryology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Abstract (english)
Congenital human cytomegalovirus (cHCMV) infection of the brain is associated with a wide range of neurocognitive sequelae. Using infection of newborn mice with mouse cytomegalovirus (MCMV) as a reliable model that recapitulates many aspects of cHCMV infection, including disseminated infection, CNS infection, altered neurodevelopment, and sensorineural hearing loss, we have previously shown that mitigation of inflammation prevented alterations in cerebellar development, suggesting that host inflammatory factors are key drivers of neurodevelopmental defects. Here, we show that MCMV infection causes a dramatic increase in the expression of the microglia-derived chemokines CXCL9/CXCL10, which recruit NK and ILC1 cells into the brain in a CXCR3-dependent manner. Surprisingly, brain-infiltrating innate immune cells not only were unable to control virus infection in the brain but also orchestrated pathological inflammatory responses, which lead to delays in cerebellar morphogenesis. Our results identify NK and ILC1 cells as the major mediators of immunopathology in response to virus infection in the developing CNS, which can be prevented by anti–IFN-γ antibodies.
Keywords (english)
Languageenglish
Publication typeScientific paper - Preliminary note / Short communication
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleJournal of Experimental Medicine
Numberingvol. 218, no. 5, pp. 1-14, e20201503
p-ISSN0022-1007
e-ISSN1540-9538
DOIhttps://doi.org/10.1084/jem.20201503
URN:NBNurn:nbn:hr:184:755338
Publication2021-05-03
ProjectNumber: uniri-biomed-18-234
Title (croatian): Transkriptomska analiza mikroglije nakon infekcije citomegalovirusom
Title (english): Transcriptomic analysis of microglia following cytomegalovirus infection
Leader: Berislav Lisnić
Jurisdiction: Croatia
Funding stream: Sveučilište u Rijeci
ProjectNumber: IP-2018-01-9086
Title (croatian): Novi pristup razvoju cjepiva za kongenitalnu citomegalovirusnu infekciju
Title (english): New Approach for Development of Vaccine for Cytomegalovirus Infection
Acronym: VaccongCMV
Leader: Astrid Krmpotić
Jurisdiction: Croatia
Funding stream: IP
ProjectNumber: 1R56DC015980-01
Title (english): Inflammation and Hearing Loss Following Congenital CMV Infection
Leader: Stipan Jonjić
Jurisdiction: United States
Funding stream: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS
ProjectNumber: KK.011.1.01.0006
Title (croatian): Jačanje kapaciteta CerVirVac-a za istraživanja u virusnoj imunologiji i vakcinologiji
Leader: Stipan Jonjić
Jurisdiction: Croatia
ProjectNumber: N/A
Title (croatian): Centar izvrsnosti za virusnu imunologiju i cjepiva
Title (english): Centre of Excellence for Research in Viral Immunology and the Development of New Vaccines
Acronym: CERVirVac
Leader: Stipan Jonjić
Jurisdiction: Croatia
Funding stream: ZCI
Document URLhttps://rupress.org/jem/article/doi/10.1084/jem.20201503/211828/NK-ILC1-cells-mediate-neuroinflammation-and-brain
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) icon
Created on2022-04-08 13:58:50