prikaz prve stranice dokumenta The possible involvement of granulysin mediated cytotoxicity in keratinocytes disruption in lichen planus
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Scientific paper - Original scientific paper
The possible involvement of granulysin mediated cytotoxicity in keratinocytes disruption in lichen planus
Medical hypotheses, 149 (2021); 110546. https://doi.org/10.1016/j.mehy.2021.110546
Vičić, Marijana; Sotošek, Vlatka; Brajac, Ines; Kaštelan, Marija; Prpić-Massari, Larisa

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Vičić, M., Sotošek, V., Brajac, I., Kaštelan, M. & Prpić Massari, L. (2021). The possible involvement of granulysin mediated cytotoxicity in keratinocytes disruption in lichen planus. Medical hypotheses, 149.. doi: 10.1016/j.mehy.2021.110546

Vičić, Marijana, et al. "The possible involvement of granulysin mediated cytotoxicity in keratinocytes disruption in lichen planus." Medical hypotheses, vol. 149, 2021. https://doi.org/10.1016/j.mehy.2021.110546

Vičić, Marijana, Vlatka Sotošek, Ines Brajac, Marija Kaštelan and Larisa Prpić Massari. "The possible involvement of granulysin mediated cytotoxicity in keratinocytes disruption in lichen planus." Medical hypotheses 149 (2021). https://doi.org/10.1016/j.mehy.2021.110546

Vičić, M., et al. (2021) 'The possible involvement of granulysin mediated cytotoxicity in keratinocytes disruption in lichen planus', Medical hypotheses, 149. doi: 10.1016/j.mehy.2021.110546

Vičić M, Sotošek V, Brajac I, Kaštelan M, Prpić Massari L. The possible involvement of granulysin mediated cytotoxicity in keratinocytes disruption in lichen planus. Medical hypotheses [Internet]. 2021 [cited 2024 April 27];149. doi: 10.1016/j.mehy.2021.110546

M. Vičić, V. Sotošek, I. Brajac, M. Kaštelan and L. Prpić Massari, "The possible involvement of granulysin mediated cytotoxicity in keratinocytes disruption in lichen planus", Medical hypotheses, vol. 149, 2021. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:021085. [Accessed: 27 April 2024]

Metadata
Title (english)The possible involvement of granulysin mediated cytotoxicity in keratinocytes disruption in lichen planus
AuthorMarijana Vičić
AuthorVlatka Sotošek
AuthorInes Brajac
AuthorMarija Kaštelan
AuthorLarisa Prpić-Massari
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Anaesthesiology,reanimatology and Intensive Care)
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Paediatric Dentistry)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Dermatovenerology
Abstract (english)
Lichen planus is a chronic mucocutanous disorder histopathologically characterized with a keratinocytes apoptosis, subsequent basal cell layer liquefaction and accumulation of the inflammatory infiltrate in papillary dermis. A formation of apoptotic bodies in basal cell layer is due to a cytotoxic lymphocyte attack to the basal keratinocytes. It has been demonstrated that the cytotoxic molecules included in this attack are perforin and granzyme B. Both molecules are found upregulated in CD8+ lymphocytes that are in close contact to keratinocytes. However, their amount is lower in lichen planus than in other skin disease characterized by liquefaction and vacuolar degeneration of the basal epidermal layer. This could speculate about other cytotoxic molecule such as granulysin that could mediate keratinocyte apoptosis. Therefore, in this article we hypothesize about the crucial role of granulysin molecule in keratinocytes killing that could contribute to a lichen planus pathogenesis.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleMedical hypotheses
Numberingvol. 149, 110546
p-ISSN0306-9877
DOIhttps://doi.org/10.1016/j.mehy.2021.110546
URN:NBNurn:nbn:hr:184:021085
Publication2021
ProjectNumber: uniri-biomed-18-83
Title (croatian): Uloga citotoksičnosti posredovane granulizinom i perforinom 2 u nastanku psorijaze i lihen planusa
Title (english): The role of cytotoxicity mediated by granulysin and perforin-2 in the development of psoriasis and lichen planus
Leader: Larisa Prpić Massari
Jurisdiction: Croatia
Funding stream: Sveučilište u Rijeci
Document URLhttp://bib.irb.hr/1183587
Type of resourceText
Access conditionsInstitutional access
Terms of useLicence In copyright icon
Created on2022-04-12 07:27:37