prikaz prve stranice dokumenta The role of perforin-mediated apoptosis in lichen planus lesions
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Scientific paper - Original scientific paper
The role of perforin-mediated apoptosis in lichen planus lesions
Archives of Dermatological Research, 296 (2004), 5; 226-230. https://doi.org/10.1007/s00403-004-0512-1
Kaštelan, Marija; Prpić Massari, Larisa; Gruber, Franjo; Zamolo, Gordana; Žauhar, Gordana; Čoklo, Miran; Rukavina, Danijel

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Cite this document

Kaštelan, M., Prpić Massari, L., Gruber, F., Zamolo, G., Žauhar, G., Čoklo, M. & Rukavina, D. (2004). The role of perforin-mediated apoptosis in lichen planus lesions. Archives of Dermatological Research, 296. (5), 226-230. doi: 10.1007/s00403-004-0512-1

Kaštelan, Marija, et al. "The role of perforin-mediated apoptosis in lichen planus lesions." Archives of Dermatological Research, vol. 296, no. 5, 2004, pp. 226-230. https://doi.org/10.1007/s00403-004-0512-1

Kaštelan, Marija, Larisa Prpić Massari, Franjo Gruber, Gordana Zamolo, Gordana Žauhar, Miran Čoklo and Danijel Rukavina. "The role of perforin-mediated apoptosis in lichen planus lesions." Archives of Dermatological Research 296, no. 5 (2004): 226-230. https://doi.org/10.1007/s00403-004-0512-1

Kaštelan, M., et al. (2004) 'The role of perforin-mediated apoptosis in lichen planus lesions', Archives of Dermatological Research, 296(5), pp. 226-230. doi: 10.1007/s00403-004-0512-1

Kaštelan M, Prpić Massari L, Gruber F, Zamolo G, Žauhar G, Čoklo M, and sur.. The role of perforin-mediated apoptosis in lichen planus lesions. Archives of Dermatological Research [Internet]. 2004 [cited 2024 November 09];296(5):226-230. doi: 10.1007/s00403-004-0512-1

M. Kaštelan, et al., "The role of perforin-mediated apoptosis in lichen planus lesions", Archives of Dermatological Research, vol. 296, no. 5, pp. 226-230, 2004. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:661425. [Accessed: 09 November 2024]

Metadata
Title (english)The role of perforin-mediated apoptosis in lichen planus lesions
AuthorMarija Kaštelan
AuthorLarisa Prpić Massari
AuthorFranjo Gruber
AuthorGordana Zamolo
AuthorGordana Žauhar
AuthorMiran Čoklo
AuthorDanijel Rukavina
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Dermatovenerology)
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Physiology, Immunology and Pathophxsiology)
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Medical Physics and Biophysics)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Dermatovenerology
Abstract (english)
Lichen planus is recognized as a T-cell-mediated disease. Histologically, it is characterized by the formation of colloid bodies representing apoptotic keratinocytes. The apoptotic process mediated by CD8(+) cytotoxic T lymphocytes (CTLs) and NK cells mainly involves two distinct pathways: the perforin/granzyme pathway and the Fas/FasL pathway. So far, little is known regarding the role of perforin-mediated apoptosis in lichen planus. In the present study, the expression and distribution of perforin, T and NK cell subsets in the epidermis and dermis of lesional and nonlesional lichen planus skin were studied. Skin biopsy specimens from lesional and nonlesional skin of ten patients with lichen planus and eight healthy persons were analysed by immunohistochemistry. Significant accumulation of T cells, particularly of CD4(+) and CD8(+) subsets, was found in both epidermis and dermis of lichen planus lesions compared with nonlesional and healthy skin. There were no significant differences in the incidence of NK cells (CD16(+) and CD56(+)) between lesional, nonlesional and healthy skin. Perforin expression was significantly upregulated in the epidermis of lichen planus lesions. In conclusion, accumulation of perforin(+) cells in the epidermis of lichen planus lesions suggest a potential role of perforin in the apoptosis of basal keratinocytes.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleArchives of Dermatological Research
Numberingvol. 296, no. 5, pp. 226-230
p-ISSN0340-3696
e-ISSN1432-069X
DOIhttps://doi.org/10.1007/s00403-004-0512-1
URN:NBNurn:nbn:hr:184:661425
Publication2004
Document URLhttp://link.springer.com/10.1007/s00403-004-0512-1
Type of resourceText
Access conditionsRestricted access
Terms of useLicence In copyright icon
Created on2022-04-12 07:38:04