prikaz prve stranice dokumenta Growth of allogeneic sarcoma in mice subjected to halothane anesthesia and/or surgical stress
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Scientific paper - Original scientific paper
Growth of allogeneic sarcoma in mice subjected to halothane anesthesia and/or surgical stress
Anesthesia and analgesia, 69 (1989), 5; 570-574. urn:nbn:hr:184:056514
Radošević-Stašić, Biserka; Udović-Širola, Marija; Stojanov, Lovorka; Ribarić, Ljubomir; Rukavina, Daniel

Institutional repository: Repository of the University of Rijeka, Faculty of Medicine

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Radošević Stašić, B., Udović Širola, M., Stojanov, L., Ribarić, Lj. & Rukavina, D. (1989). Growth of allogeneic sarcoma in mice subjected to halothane anesthesia and/or surgical stress. Anesthesia and analgesia, 69. (5), 570-574. Retrieved from https://urn.nsk.hr/urn:nbn:hr:184:056514

Radošević Stašić, Biserka, et al. "Growth of allogeneic sarcoma in mice subjected to halothane anesthesia and/or surgical stress." Anesthesia and analgesia, vol. 69, no. 5, 1989, pp. 570-574. https://urn.nsk.hr/urn:nbn:hr:184:056514

Radošević Stašić, Biserka, Marija Udović Širola, Lovorka Stojanov, Ljubomir Ribarić and Daniel Rukavina. "Growth of allogeneic sarcoma in mice subjected to halothane anesthesia and/or surgical stress." Anesthesia and analgesia 69, no. 5 (1989): 570-574. https://urn.nsk.hr/urn:nbn:hr:184:056514

Radošević Stašić, B., et al. (1989) 'Growth of allogeneic sarcoma in mice subjected to halothane anesthesia and/or surgical stress', Anesthesia and analgesia, 69(5), pp. 570-574. Available at: https://urn.nsk.hr/urn:nbn:hr:184:056514 (Accessed 23 April 2024)

Radošević Stašić B, Udović Širola M, Stojanov L, Ribarić Lj, Rukavina D. Growth of allogeneic sarcoma in mice subjected to halothane anesthesia and/or surgical stress. Anesthesia and analgesia [Internet]. 1989 [cited 2024 April 23];69(5):570-574. Available at: https://urn.nsk.hr/urn:nbn:hr:184:056514

B. Radošević Stašić, M. Udović Širola, L. Stojanov, Lj. Ribarić and D. Rukavina, "Growth of allogeneic sarcoma in mice subjected to halothane anesthesia and/or surgical stress", Anesthesia and analgesia, vol. 69, no. 5, pp. 570-574, 1989. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:056514. [Accessed: 23 April 2024]

Metadata
Title (english)Growth of allogeneic sarcoma in mice subjected to halothane anesthesia and/or surgical stress
AuthorBiserka Radošević-Stašić
AuthorMarija Udović-Širola
MBZ: 146291
AuthorLovorka Stojanov
AuthorLjubomir Ribarić
MBZ: 134591
AuthorDaniel Rukavina
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Anaesthesiology,reanimatology and Intensive Care)
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Physiology, Immunology and Pathophxsiology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Immunology
Abstract (english)
The present study was designed to clarify mechanisms involved in suppression of cell-mediated immunity reported in patients undergoing major surgery with general anesthesia by determining the effects of halothane anesthesia with and without surgery on the growth of Sarcoma I (Sa I), a tumor allogeneic to BALB/c mice. Mice were given subcutaneous injections of 5 × 106 tumor cells from A/Jax mice and then immediately exposed to 0.5%-1.0% halothane for 1 hr without surgery (n = 7) or with surgery (midline laparotomy ; n = 12). In control groups mice were also injected with tumor cells but were not exposed to prolonged halothane anesthesia. Some of them received only Sa 1 (n = 6), while the rest (n = 7) were also laparotomized. The rejection time of Sa I in mice exposed to halothane anesthesia was significantly longer (15.4 ± 1.25 days) than in untreated controls (12.10 ± 0.68 days) (P < 0.05). In the mice exposed to halothane tumor growth was also greater. Surgical stress per se did not significantly affect growth or rejection time of Sa I(11.0 ± 0.66 vs 12.0 ± 0.68 days). Similarly, the combination of surgical stress with halothane anesthesia did not affect the immunosuppression associated with halothane alone (12.9 ± 1.3 vs 15.4 ± 1.25 ; P < 0.05). The results indicate that halothane anesthesia per se may be associated with impairment of cell-mediated immunity under experimental conditions.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleAnesthesia and analgesia
Numberingvol. 69, no. 5, pp. 570-574
p-ISSN0003-2999
URN:NBNurn:nbn:hr:184:056514
Publication1989
Document URLhttp://bib.irb.hr/195084
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2022-04-14 07:06:37