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master's thesis
Dijagnostika i liječenje tumora kanalnog sustava bubrega i mokraćovoda
Rijeka: University of Rijeka, Faculty of Medicine, 2022. urn:nbn:hr:184:064282
Bukša, Iva
University of Rijeka
Faculty of Medicine
Department of Urology

Institutional repository: Repository of the University of Rijeka, Faculty of Medicine

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Bukša, I. (2022). Dijagnostika i liječenje tumora kanalnog sustava bubrega i mokraćovoda (Master's thesis). Rijeka: University of Rijeka, Faculty of Medicine. Retrieved from https://urn.nsk.hr/urn:nbn:hr:184:064282

Bukša, Iva. "Dijagnostika i liječenje tumora kanalnog sustava bubrega i mokraćovoda." Master's thesis, University of Rijeka, Faculty of Medicine, 2022. https://urn.nsk.hr/urn:nbn:hr:184:064282

Bukša, Iva. "Dijagnostika i liječenje tumora kanalnog sustava bubrega i mokraćovoda." Master's thesis, University of Rijeka, Faculty of Medicine, 2022. https://urn.nsk.hr/urn:nbn:hr:184:064282

Bukša, I. (2022). 'Dijagnostika i liječenje tumora kanalnog sustava bubrega i mokraćovoda', Master's thesis, University of Rijeka, Faculty of Medicine, accessed 25 December 2024, https://urn.nsk.hr/urn:nbn:hr:184:064282

Bukša I. Dijagnostika i liječenje tumora kanalnog sustava bubrega i mokraćovoda [Master's thesis]. Rijeka: University of Rijeka, Faculty of Medicine; 2022 [cited 2024 December 25] Available at: https://urn.nsk.hr/urn:nbn:hr:184:064282

I. Bukša, "Dijagnostika i liječenje tumora kanalnog sustava bubrega i mokraćovoda", Master's thesis, University of Rijeka, Faculty of Medicine, Rijeka, 2022. Available at: https://urn.nsk.hr/urn:nbn:hr:184:064282

Metadata
TitleDijagnostika i liječenje tumora kanalnog sustava bubrega i mokraćovoda
Title (english)Diagnosis and Treatment of Upper Urinary Tract Cancer
AuthorIva Bukša
MentorStanislav Sotošek (mentor)
Committee memberRomano Oguić (predsjednik povjerenstva)
Committee memberDean Markić (član povjerenstva)
Committee memberJosip Španjol (član povjerenstva)
GranterUniversity of Rijeka
Faculty of Medicine
(Department of Urology)
Rijeka
Defense date and country2022-06-08, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Urology
Abstract
Urotelni karcinom gornjeg urotrakta je relativno rijedak tumor u usporedbi s urotelnim karcinomom donjeg urotrakta te čini samo 5-10% svih urotelnih novotvorina. Unatoč zajedničkom podrijetlu i histološkim karakteristikama oba entiteta, praksa je pokazala da je, u trenutku postavljanja dijagnoze, karcinom gornjeg urotrakta invazivniji, s lošijom prognozom, te petogodišnjom stopom smrtnosti od 23%. Najčešći simptom s kojim se prezentira bolesnik, a koji se javlja u čak 70-80% slučajeva, je makro- ili mikrohematurija. U oko 25% bolesnika, kao vodeći simptom, se javlja bol u lumbalnoj regiji, dok je prezentacija palpabilne abdominalne mase vrlo rijetka. Kompjutorizirana tomografija (CT) urografija pokazuje visoku specifičnost i senzitivnost za dijagnosticiranje karcinoma gornjeg urotrakta, ali je njezina vrijednost ograničena u stagingu bolesti. Fleksibilna ureterorenoskopija s biopsijom također je izrazito precizna dijagnostička metoda, međutim, slično kao kod CT-a, i ona pokazuje ograničenja u stagingu. Ipak, Europsko udruženje urologa preporučuje izvođenje ureteroskopom vođene biopsije kod svih pacijenata sa sumnjom na karcinom gornjeg urotrakta. Do danas, zlatnim standardom u liječenju ovih bolesnika pokazala se radikalna nefroureterektomija (RNU), osim u bolesnika s jednim bubregom, kada je indicirano liječenje metodama poštednim za bubreg.
Abstract (english)
Upper tract urothelial carcinoma, in comparison to urothelial carcinoma of the lower urinary tract, is not that common. It accounts for under 10% of all urothelial neoplasms. Despite the common origin and histological characteristics of both entities, practice has shown that, at diagnosis, upper tract carcinoma is more invasive, hence the poorer outcome, and a five-year mortality rate of 23%. The most common symptom, that is present in 70-80% of cases, is macro- or microhematuria. In about 25% of patients, pain in the lumbar region occurs as the leading symptom, while the presentation of palpable abdominal mass is very rare. Computed tomography (CT) urography shows high specificity and sensitivity for diagnosing upper tract carcinoma, but its value is limited in staging. Flexible ureterorenoscopy followed by biopsy is also highly effective diagnostic method. However, similar to the CT, it also shows limitations when it come to staging. Nevertheless, the European Association of Urologists recommends performing ureteroscopic biopsies when upper tract cancer is suspected. To date, radical nephroureterectomy (RNU) has proven to be the gold standard when treating these patients. For solitary kidney patients and those that could not withstand such a radical surgery, kidney-sparing methods are indicated.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:184:064282
Study programmeTitle: Medicine
Study programme type: university
Study level: integrated undergraduate and graduate
Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2022-06-25 12:48:15