prikaz prve stranice dokumenta Mesenchymal Stem Cell Mechanisms of Action and Clinical Effects in Osteoarthritis: A Narrative Review
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Scientific paper - Review paper
Mesenchymal Stem Cell Mechanisms of Action and Clinical Effects in Osteoarthritis: A Narrative Review
Genes, 13 (2022), 6; 949. https://doi.org/10.3390/genes13060949
Molnar, Vilim; Pavelić, Eduard; Vrdoljak, Kristijan; Čemerin, Martin; Klarić, Emil; Matišić, Vid; Bjelica, Roko; Brlek, Petar; Kovačić, Ivana; Tremolada, Carlo; Primorac, Dragan

Institutional repository: Repository of the University of Rijeka, Faculty of Medicine

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Molnar, V., Pavelić, E., Vrdoljak, K., Čemerin, M., Klarić, E., Matišić, V. ... Primorac, D. (2022). Mesenchymal Stem Cell Mechanisms of Action and Clinical Effects in Osteoarthritis: A Narrative Review. Genes, 13. (6). doi: 10.3390/genes13060949

Molnar, Vilim, et al. "Mesenchymal Stem Cell Mechanisms of Action and Clinical Effects in Osteoarthritis: A Narrative Review." Genes, vol. 13, no. 6, 2022. https://doi.org/10.3390/genes13060949

Molnar, Vilim, Eduard Pavelić, Kristijan Vrdoljak, Martin Čemerin, Emil Klarić, Vid Matišić, Roko Bjelica, et al. "Mesenchymal Stem Cell Mechanisms of Action and Clinical Effects in Osteoarthritis: A Narrative Review." Genes 13, no. 6 (2022). https://doi.org/10.3390/genes13060949

Molnar, V., et al. (2022) 'Mesenchymal Stem Cell Mechanisms of Action and Clinical Effects in Osteoarthritis: A Narrative Review', Genes, 13(6). doi: 10.3390/genes13060949

Molnar V, Pavelić E, Vrdoljak K, Čemerin M, Klarić E, Matišić V, and sur.. Mesenchymal Stem Cell Mechanisms of Action and Clinical Effects in Osteoarthritis: A Narrative Review. Genes [Internet]. 2022 [cited 2024 July 23];13(6). doi: 10.3390/genes13060949

V. Molnar, et al., "Mesenchymal Stem Cell Mechanisms of Action and Clinical Effects in Osteoarthritis: A Narrative Review", Genes, vol. 13, no. 6, 2022. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:643341. [Accessed: 23 July 2024]

Metadata
Title (english)Mesenchymal Stem Cell Mechanisms of Action and Clinical Effects in Osteoarthritis: A Narrative Review
AuthorVilim Molnar
AuthorEduard Pavelić
AuthorKristijan Vrdoljak
AuthorMartin Čemerin
AuthorEmil Klarić
AuthorVid Matišić
AuthorRoko Bjelica
AuthorPetar Brlek
AuthorIvana Kovačić
AuthorCarlo Tremolada
AuthorDragan Primorac
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Biology and Medical Genetics)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
With the insufficient satisfaction rates and high cost of operative treatment for osteoarthritis (OA), alternatives have been sought. Furthermore, the inability of current medications to arrest disease progression has led to rapidly growing clinical research relating to mesenchymal stem cells (MSCs). The availability and function of MSCs vary according to tissue source. The three primary sources include the placenta, bone marrow, and adipose tissue, all of which offer excellent safety profiles. The primary mechanisms of action are trophic and immunomodulatory effects, which prevent the further degradation of joints. However, the function and degree to which benefits are observed vary significantly based on the exosomes secreted by MSCs. Paracrine and autocrine mechanisms prevent cell apoptosis and tissue fibrosis, initiate angiogenesis, and stimulate mitosis via growth factors. MSCs have even been shown to exhibit antimicrobial effects. Clinical results incorporating clinical scores and objective radiological imaging have been promising, but a lack of standardization in isolating MSCs prevents their incorporation in current guidelines.
Keywords (english)
Languageenglish
Publication typeScientific paper - Review paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleGenes
Numberingvol. 13, no. 6, 949
p-ISSN2073-4425
DOIhttps://doi.org/10.3390/genes13060949
URN:NBNurn:nbn:hr:184:643341
Publication2022
Document URLhttp://bib.irb.hr/1202160
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2022-06-29 08:01:36