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master's thesis
Eksperimentalna upotreba čimbenika poticanja rasta granulocitnih kolonija (G-CSF) u kliničkoj praksi
Rijeka: University of Rijeka, Faculty of Medicine, 2022. urn:nbn:hr:184:477484
Omerović, Alen
University of Rijeka
Faculty of Medicine
Department of Internal Medicine

Institutional repository: Repository of the University of Rijeka, Faculty of Medicine

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Omerović, A. (2022). Eksperimentalna upotreba čimbenika poticanja rasta granulocitnih kolonija (G-CSF) u kliničkoj praksi (Master's thesis). Rijeka: University of Rijeka, Faculty of Medicine. Retrieved from https://urn.nsk.hr/urn:nbn:hr:184:477484

Omerović, Alen. "Eksperimentalna upotreba čimbenika poticanja rasta granulocitnih kolonija (G-CSF) u kliničkoj praksi." Master's thesis, University of Rijeka, Faculty of Medicine, 2022. https://urn.nsk.hr/urn:nbn:hr:184:477484

Omerović, Alen. "Eksperimentalna upotreba čimbenika poticanja rasta granulocitnih kolonija (G-CSF) u kliničkoj praksi." Master's thesis, University of Rijeka, Faculty of Medicine, 2022. https://urn.nsk.hr/urn:nbn:hr:184:477484

Omerović, A. (2022). 'Eksperimentalna upotreba čimbenika poticanja rasta granulocitnih kolonija (G-CSF) u kliničkoj praksi', Master's thesis, University of Rijeka, Faculty of Medicine, accessed 06 May 2024, https://urn.nsk.hr/urn:nbn:hr:184:477484

Omerović A. Eksperimentalna upotreba čimbenika poticanja rasta granulocitnih kolonija (G-CSF) u kliničkoj praksi [Master's thesis]. Rijeka: University of Rijeka, Faculty of Medicine; 2022 [cited 2024 May 06] Available at: https://urn.nsk.hr/urn:nbn:hr:184:477484

A. Omerović, "Eksperimentalna upotreba čimbenika poticanja rasta granulocitnih kolonija (G-CSF) u kliničkoj praksi", Master's thesis, University of Rijeka, Faculty of Medicine, Rijeka, 2022. Available at: https://urn.nsk.hr/urn:nbn:hr:184:477484

Metadata
TitleEksperimentalna upotreba čimbenika poticanja rasta granulocitnih kolonija (G-CSF) u kliničkoj praksi
Title (english)Experimental use of granulocyte-colony stimulating factor (G-CSF) in clinical practice
AuthorAlen Omerović
MentorDuška Petranović (mentor)
Committee memberInes Mrakovčić-Šutić (predsjednik povjerenstva)
Committee memberSanja Klobučar-Majanović (član povjerenstva)
Committee memberIngrid Belac-Lovasić (član povjerenstva)
GranterUniversity of Rijeka
Faculty of Medicine
(Department of Internal Medicine)
Rijeka
Defense date and country2022-07-15, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Internal Medicine
Abstract
G-CSF je faktor rasta bijelih krvnih stanica koji pospješuje maturaciju neutrofila koji igraju ključnu ulogu u antimikrobnom djelovanju te također stimulira njihovu proliferaciju i potiče prelazak iz koštane srži u krv. Vezanjem na homodimerni receptor, G-CSFR, ostvaruje svoje učinke. Kliničkim istraživanjima na animalnim modelima, a kasnije i eksperimentalnom upotrebom u ljudi, došlo se do mnogobrojnih spoznaja o samom učinku i mehanizmu djelovanja G-CSF-a. Provedenim istreživanjima dokazani su mnogobrojni pozitivni učinci koji uključuju blokiranje učinaka LPS-a modifikacijom odgovora citokina, smanjenje učestalosti amputacije ekstremiteta i kirurških zahvata povezanih s komplikacijama dijabetičkog stopala, indukciju mobilizacije matičnih stanica i progenitornih stanica uz izravan učinak na kardiomiocite u miokardu koji je pretrpio infarkt ili kod kroničnog srčanog zatajenja. Sigurnost i učinkovitost njegove primjene potrebno je potvrditi dodatnim kliničkim ispitivanjima, ali dosadašnja istraživanja sugeriraju da bi primjena G-CSF-a mogla predstavljati novu terapijsku strategiju za liječenje bolesnika s kroničnim zatajenjem srca, dijabetičkim stopalom ili bakterijskom infekcijom.
Abstract (english)
G-CSF is a white blood cell growth factor that promotes the maturation of neutrophils that play a key role in antimicrobial activity and also stimulates their proliferation and promotes the transition from bone marrow to blood. By binding to the homodimeric receptor, G-CSFR, it exerts its effects. Clinical research on animal models, and later experimental use in humans, has provided much insight into the effect and mechanism of action of G-CSF. Numerous positive effects have been demonstrated, including blocking the effects of LPS by modifying cytokine responses, reducing the frequency of limb amputations and surgical procedures associated with diabetic foot complications, inducing stem cell and progenitor cell mobilization with a direct effect on cardiomyocytes or myocardial infarction. in chronic heart failure. The safety and efficacy of its use need to be confirmed by additional clinical trials, but research to date suggests that the use of G-CSF could represent a new therapeutic strategy for the treatment of patients with chronic heart failure, diabetic foot or bacterial infection
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:184:477484
Study programmeTitle: Medicine
Study programme type: university
Study level: integrated undergraduate and graduate
Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2022-07-02 18:12:42