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master's thesis
Prevencija bronhopulmonalne displazije: postnatalna primjena kortikosteroida
Rijeka: University of Rijeka, Faculty of Medicine, 2022. urn:nbn:hr:184:885799
Smeraldo, Sara
University of Rijeka
Faculty of Medicine
Department of Pediatrics

Institutional repository: Repository of the University of Rijeka, Faculty of Medicine

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Smeraldo, S. (2022). Prevencija bronhopulmonalne displazije: postnatalna primjena kortikosteroida (Master's thesis). Rijeka: University of Rijeka, Faculty of Medicine. Retrieved from https://urn.nsk.hr/urn:nbn:hr:184:885799

Smeraldo, Sara. "Prevencija bronhopulmonalne displazije: postnatalna primjena kortikosteroida." Master's thesis, University of Rijeka, Faculty of Medicine, 2022. https://urn.nsk.hr/urn:nbn:hr:184:885799

Smeraldo, Sara. "Prevencija bronhopulmonalne displazije: postnatalna primjena kortikosteroida." Master's thesis, University of Rijeka, Faculty of Medicine, 2022. https://urn.nsk.hr/urn:nbn:hr:184:885799

Smeraldo, S. (2022). 'Prevencija bronhopulmonalne displazije: postnatalna primjena kortikosteroida', Master's thesis, University of Rijeka, Faculty of Medicine, accessed 03 May 2024, https://urn.nsk.hr/urn:nbn:hr:184:885799

Smeraldo S. Prevencija bronhopulmonalne displazije: postnatalna primjena kortikosteroida [Master's thesis]. Rijeka: University of Rijeka, Faculty of Medicine; 2022 [cited 2024 May 03] Available at: https://urn.nsk.hr/urn:nbn:hr:184:885799

S. Smeraldo, "Prevencija bronhopulmonalne displazije: postnatalna primjena kortikosteroida", Master's thesis, University of Rijeka, Faculty of Medicine, Rijeka, 2022. Available at: https://urn.nsk.hr/urn:nbn:hr:184:885799

Metadata
TitlePrevencija bronhopulmonalne displazije: postnatalna primjena kortikosteroida
Title (english)Prevention of bronchopulmonary dysplasia: postnatal use of corticosteroids
AuthorSara Smeraldo
MentorIva Bilić Čače (mentor)
Committee memberKristina Lah Tomulić (predsjednik povjerenstva)
Committee memberAna Milardović (član povjerenstva)
Committee memberAna Bosak Veršić (član povjerenstva)
GranterUniversity of Rijeka
Faculty of Medicine
(Department of Pediatrics)
Rijeka
Defense date and country2022-07-15, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Pediatrics
Abstract
Bronhopulmonalna displazija (kronična plućna bolest) je multifakorijalna plućna bolest novorođenčadi koja pretežno pogađa prematuruse < 32 tjedna gestacije i rodne mase manje od 1250 g. Patogeneza joj se temelji na primarno nedovoljno zrelim plućima i plućnoj ozljedi koja može nastati zbog mehaničke distenzije dišnih puteva, toksičnog djelovanja kisika, infekcije i drugih uzroka. Klinička slika može biti vrlo varijabilna, ali najčešće uključuje pojavu tahipnoičnog disanja i inspiratornih retrakcija te kod težih oblika bolesti razvoj hipoksije i hiperkapnije. Većina pacijenata oporavi se u potpunosti kroz 2-4 mjeseca, no u pojedinim slučajevima klinički tijek se komplicira te je potrebna potpora dodatnim kisikom duže od šest mjeseci. Dugoročna poslijedica BPD je smanjena plućna funkcija i povećana sklonost razvoja težih kliničkih slika infektivnih respiratornih bolesti. Prevencija BPD može obuhvatiti antenatalne i postnatalne terapijske metode. U ovome istraživanju sudjelovalo je 29 pacijenata GD <31 i RM <1400 g te su svi primali kortikosteroidnu terapiju (DART, Pulmicort ili oboje) u svrhu prevencije BPD. Promatrala se dužina hospitalizacije i moguće nuspojave u odnosu na vrstu terapije. Dobiveni rezultati statistički nisu značajni, ali se uočava trend u kojemu najkraću hospitalizaciju imaju pacijenti na terapiji Pulmicortom (49 dana), zatim prema DART protokolu (60 dana) i najdužu kod obje teapije (92 dana). Također, pacijenti na terapiji prema DART protokolu su imali patološke promjene na zadnjem UTZ mozga u 71% slučajeva nakon početno urednog nalaza. Postnatalna primjena kortikosteroida zahtjeva dodatna istraživanja kojima će se bolje razumjeti njihov učinak i razvoj nuspojava na prematuruse. Administrira se kod pacijenata kod kojih benefit nadvladava mogući rizik terapije.
Abstract (english)
Bronchopulmonary dypslasia (chronic lung disease) is a lung disorder that affects preterm infants, particularly those born before the 32nd week of gestation and those with a birth weight below 1250g. BPD is primarily caused by a lack of lung maturation at birth and pulmonary tissue damage which can be caused by mechanical trauma, oxygen poisoning and infection. Clincal findings differ between patients. Most patients present with tachypnea and respiratory retractions while hypoxia and hyperkapnia is present in severe cases. Most patients make a complete recovery in about 2-4 months, however complicated and severe cases may require oxygen supplementation >6 months after birth. Long-term consequences of BPD include a decreased pulmonary function and frequent complicated pulmonary infections. BPD prevention includes antenatal and postnatal methods. In this study 29 patients with a gestational age below 31 weeks and weight at birth below 1400g were treated with corticosteroids (DART, Pulmicort or both) for BPD prevention. Differences in hospital stay and therapy side effects were observed. A pattern was noted in which the patients treated with Pulmicort had the shortest hospital stay (49 days), followed by the patients treated with DART (60 days) and the longest stay was noted in those treated with both (92), however no statistically significant differences were found between the 3 groups. 71% of patients treated with the DART protocol that had a regular initial ultrasound had an abnormal ultrasound after therapy was completed. Postnatal corticosteriod use requires more studies in which their effectiveness and side effects should be properly assessed. It is currently administered in patients whose benefit should be higher than the possible side effects.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:184:885799
Study programmeTitle: Medicine
Study programme type: university
Study level: integrated undergraduate and graduate
Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2022-07-08 11:23:04