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master's thesis
KLINIČKE ZNAČAJKE BOLESNIKA S INVAZIVNIM KARCINOMOM MOKRAĆNOG MJEHURA
Rijeka: University of Rijeka, Faculty of Medicine, 2022. urn:nbn:hr:184:289966
Nović, Bernard
University of Rijeka
Faculty of Medicine
Department of Urology

Institutional repository: Repository of the University of Rijeka, Faculty of Medicine

Cite this document

Nović, B. (2022). KLINIČKE ZNAČAJKE BOLESNIKA S INVAZIVNIM KARCINOMOM MOKRAĆNOG MJEHURA (Master's thesis). Rijeka: University of Rijeka, Faculty of Medicine. Retrieved from https://urn.nsk.hr/urn:nbn:hr:184:289966

Nović, Bernard. "KLINIČKE ZNAČAJKE BOLESNIKA S INVAZIVNIM KARCINOMOM MOKRAĆNOG MJEHURA." Master's thesis, University of Rijeka, Faculty of Medicine, 2022. https://urn.nsk.hr/urn:nbn:hr:184:289966

Nović, Bernard. "KLINIČKE ZNAČAJKE BOLESNIKA S INVAZIVNIM KARCINOMOM MOKRAĆNOG MJEHURA." Master's thesis, University of Rijeka, Faculty of Medicine, 2022. https://urn.nsk.hr/urn:nbn:hr:184:289966

Nović, B. (2022). 'KLINIČKE ZNAČAJKE BOLESNIKA S INVAZIVNIM KARCINOMOM MOKRAĆNOG MJEHURA', Master's thesis, University of Rijeka, Faculty of Medicine, accessed 13 May 2024, https://urn.nsk.hr/urn:nbn:hr:184:289966

Nović B. KLINIČKE ZNAČAJKE BOLESNIKA S INVAZIVNIM KARCINOMOM MOKRAĆNOG MJEHURA [Master's thesis]. Rijeka: University of Rijeka, Faculty of Medicine; 2022 [cited 2024 May 13] Available at: https://urn.nsk.hr/urn:nbn:hr:184:289966

B. Nović, "KLINIČKE ZNAČAJKE BOLESNIKA S INVAZIVNIM KARCINOMOM MOKRAĆNOG MJEHURA", Master's thesis, University of Rijeka, Faculty of Medicine, Rijeka, 2022. Available at: https://urn.nsk.hr/urn:nbn:hr:184:289966

Metadata
TitleKLINIČKE ZNAČAJKE BOLESNIKA S INVAZIVNIM KARCINOMOM MOKRAĆNOG MJEHURA
Title (english)CLINICAL FEATURES OF PATIENTS WITH INVASIVE BLADDER CANCER
AuthorBernard Nović
MentorDean Markić (mentor)
Committee memberRomano Oguić (predsjednik povjerenstva)
Committee memberStanislav Sotošek (član povjerenstva)
Committee memberJosip Španjol (član povjerenstva)
GranterUniversity of Rijeka
Faculty of Medicine
(Department of Urology)
Rijeka
Defense date and country2022-07-15, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Urology
Abstract
Karcinom mokraćnog mjehura je jedan od najčešćih karcinoma te zauzima značajno mjesto u stopama mortaliteta i incidencije na razini RH i svijeta. Svrha ovog rada jest prikazati i usporediti kliničke značajke bolesnika koji su operirani zbog mišićno invazivnog karcinoma mokraćnog mjehura kroz tri godine. U ovo su ispitivanje uvršteni bolesnici koji su u razdoblju od 1. siječnja 2017.godine do 31. prosinca 2019. godine podvrgnuti operativnom zahvatu na Klinici za urologiju Kliničkog bolničkog centra Rijeka zbog invazivnog karcinoma mokraćnog mjehura. Bolesnici su podijeljeni obzirom na metodu urinarne derivacije koja je kod njih provedena. Analizirane su demografske i kliničke značajke bolesnika. Ukupno je 97 bolesnika podvrgnuto operativnom zahvatu. Od toga 75 (77,3%) su bili muškarci, a 22 (22,6%) žene. Prosječna je dob bolesnika bila 70 godina i 4 mjeseca. Ureterokutaneostoma je učinjena kod 47 bolesnika, ileum conduit po Brickeru je učinjen kod 20 bolesnika, neovezika po Studeru kod 14, a neovezika po Hautmannu kod 13 bolesnika. Jedna je bolesnica bila anefrična i kod nje nije učinjena urinarna derivacija, a jednom je bolesniku postavljena nefrostomija. Prosječna je vrijednost eGFRa iznosila 63,2mL/1,73m2/s, a prosječna razina serumskog kreatinina 134,9µmol/L. Bolesnici s neovezikom po Studeru su imali prosječno najviše vrijednosti eGFRa, a najniže su zabilježene kod bolesnika s ureterokutaneostomom. MIBC se češće javlja kod muškaraca i starijih osoba. Najčešći je početni simptom hematurija. Najčešća je primijenjena metoda liječenja radikalna cistektomija uz moguću primjenu radioterapije te neoadjuvantne i adjuvantne kemoterapije.
Abstract (english)
Bladder cancer is one of the mmost common types of cancer. Bladder cancer occupies a significant spot in the mortality and incidence rates in Croatia and in the rest of the world. The purpose of this paper is to present and compare the clinical features of the patients that underwent surgery through three years. This study included patients which underwent surgery for invasive bladder cancer between January 1st, 2017, and December 31st, 2019, at the Department of Urology of the Clinical Hospital Center Rijeka. Patients were divided according to the urinary derivation method used on each patient and their data were evaluated. Demographics and clinical characteristics of the patients were analyzed. A total of 97 patients underwent surgery. Out of these, 22 (22.6%) were female and 75 (77.3%) were male. The average age of the patients was 70 years and 4 months. 47 patients had ureterocutaneostomies done, along with 20 ileum conduits according to Bricker, 14 Studer neobladders, and 13 Hautmann neobladders. One patient was anephric and no urinary diversion was performed and one patient got a nephrostomy. Mean serum creatinine levels were 134.9 µmol/L and 63.2 mL/1.73 m2 /s, respectively, for eGFR. The patients with Studer neobladder had the highest average eGFR rate, while patients with ureterocutaneostomy had the lowest values. Men and older people are more likely to have MIBC. Hematuria is the most typical first sign. Radiation therapy, preoperative chemotherapy, and adjuvant chemotherapy may be utilized in addition to the most popular treatment option, radical cystectomy.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:184:289966
Study programmeTitle: Medicine
Study programme type: university
Study level: integrated undergraduate and graduate
Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2022-07-10 20:28:57