Multiple myeloma is a malignant bone marrow disease characterized by neoplastic proliferation of plasma cells, accompanied by an abnormal increase in monoclonal immunoglobulins that can be detected in serum or urine. Despite significant improvements in the treatment of multiple myeloma, it is still a chronic, incurable disease that is associated with reduced HRQoL due to spontaneous fractures, osteolytic lesions, recurrent infections, renal failure, anaemia and psychological disorders and other related problems. By assessing a patient’s HRQoL regularly throughout their disease, clinicians can gain insight into the patient's health condition, pain level, physical functioning, and they can develop a treatment plan accordingly. The most often used questionnaires in assessment of HRQoL in patients with multiple myeloma such as EORTC QLQ-C30 and EORTC QLQ-MY20, according to the results of individual researches, are not good enough, and it is necessary to work on their improvement. The introduction of novel therapies over the past few years has led to significant improvement in survival, but side effects of some treatment cause a significant reduction in HRQoL. Therefore, in routine clinical care, attention must be paid to monitoring HRQoL after the application of certain therapeutic protocols. In addition to treatment of the disease itself, prophylaxis and supportive treatment of bone destruction, pain, anaemia, renal failure, fatigue, infections, hypercalcaemia and peripheral neuropathy are essential parts of the therapeutic management of multiple myeloma patients.