Title CCR5-Δ32 mutacija i pandemija COVID-19 u Europi Title (english) CCR5-Δ32 mutation and the COVID-19 pandemic in Europe Author Matea Suša Mentor Smiljana Ristić (mentor)Committee member Nada Starčević Čizmarević (predsjednik povjerenstva)Committee member Sanja Dević Pavlić (član povjerenstva)Granter University of Rijeka Defense date and country 2022-09-09, Croatia Scientific / art field, BIOMEDICINE AND HEALTHCARE Abstract COVID-19 infektivna je respiratorna bolest uzrokovana SARS-CoV-2 virusom, koja se brzo proširila svijetom u posljednje dvije godine. Dosadašnja saznanja upućuju na to da se radi o iznimno složenoj multifaktorijalnoj i poligenskoj bolesti u kojoj su brojni genetički i epigenetički čimbenici odgovorni za vrlo varijabilnu fenotipsku ekspresiju. Sve je više dokaza da genetika domaćina može utjecati na predispoziciju i razvoj COVID-19. CCR5 je receptor za proupalne kemokine koji sudjeluju u odgovoru domaćina, posebice na viruse. Mutacija CCR5-Δ32 zanimljiva je genetička varijanta s obzirom na njezinu ulogu u nekim virusnim infekcijama, posebice HIV-1. Nedavne studije o učincima CCR5-Δ32 mutacije na rizik i težinu COVID-19 dale su proturječne rezultate. Cilj naše studije bio je učiniti statističku reanalizu epidemioloških studija provedenih u 39 europskih zemalja nakon dvije godine pandemije i pokušati rasvijetliti još uvijek kontroverzan utjecaj CCR5-Δ32 mutacije na COVID-19. Koristeći multiplu regresijsku analizu, ispitali smo povezanost između učestalosti CCR5-Δ32 mutacije i prevalencije i smrtnosti od COVID-19, kontrolirajući u statističkoj analizi intenzitet testiranja, proteklo vrijeme od početka pandemije, HDI te procijepljenost stanovništva u svakoj od analiziranih zemalja. Naši rezultati pokazuju da učestalost CCR5-Δ32 mutacije nije značajno povezana s brojem slučajeva COVID-19 (p=0,997), ali je značajno negativno povezana s brojem smrtnih slučajeva (p=0,028) u europskoj populaciji, uzimajući u obzir broj dijagnostičkih testova i broj dana od početka epidemije u svakoj zemlji kao potencijalne zbunjujuće čimbenike. Ovi rezultati sugeriraju da CCR5-Δ32 mutacija može imati protektivan učinak na mortalitet od SARS-CoV-2, no potrebna su daljnja istraživanja populacija s različitim genetičkim podrijetlom kako bi se potvrdili ovi statistički dobiveni rezultati.
Abstract (english) COVID-19 is an infectious respiratory disease caused by the SARS-CoV-2 virus, which has spread rapidly worldwide in the last two years.
Current knowledge suggests that it is an extremely complex multifactorial and polygenic disease in which multiple genetic and epigenetic factors are responsible for highly variable phenotypic expression. There is increasing evidence that host genetics is a factor in the prevalence and progression of COVID19. CCR5 is a receptor for proinflammatory chemokines involved in host responses, particularly to viruses. The CCR5-Δ32 mutation is an interesting genetic variant given the role of CCR5 in some viral infections, particularly HIV-1. Recent studies on the effects of CCR5-Δ32 on the risk and severity of COVID -19 have yielded conflicting results.
The aim of our study was to statistically reanalyze epidemiological studies conducted in 39 European countries after two pandemic years and attempt to shed light on the still controversial impact of the CCR5-Δ32 mutation on COVID-19.
Using multiple regression, we examined the association between CCR5-Δ32 frequency and COVID -19 prevalence and mortality, adjusting for test intensity, time elapsed since epidemic onset, Human Development Index, and COVID-19 vaccination in each country.
Our results show that CCR5-Δ32 allele frequency in a European population was not significantly correlated with the number of COVID-19 cases (p=0,997), but was significantly negatively correlated with the number of deaths (p=0,028) after adjusting for the number of diagnostic tests and the onset of the epidemic (days) in each country as potential confounders. These results suggest that CCR5-Δ32 mutation may be protective against SARS-CoV-2 mortality, but further studies based on samples from populations with different genetic backgrounds are needed to validate these statistically obtained findings.
Keywords
COVID-19
SARS-CoV-2
CCR5-Δ32
CCR5
Keywords (english)
COVID-19
SARS-CoV-2
CCR5-Δ32
CCR5
Language croatian URN:NBN urn:nbn:hr:184:348393 Study programme Title: Study of Sanitary Engineering Type of resource Text File origin Born digital Access conditions Open access Terms of use Created on 2022-09-06 09:37:03
