When we talk about iron, we mention it as one of the main biogenic metals. It is essential for the transfer of oxygen in the body and an integral part of many enzymes and vitamins. The issue frequently mentioned in medicine is the one of iron deficiency that occours due to its slow absorption in the digestive tract and frequent losses, mainly in the female population. In contrast, extremely high levels of this metal in circulation have been noted in moderate and severe forms of COVID-19 infection. Studies of the conditions of high iron levels in the blood have revealed interesting findings. Evidence suggests that the SARS-CoV-2 virus, the causative agent of COVID-19 disease, has an affinity for erythrocytes, namely 1-beta chains of hemoglobin. The virus causes a breakdown of these units, thus releasing iron in an ion form, which becomes free in the cell or in circulation and causes a number of health complications. The most significant of these is the direct effect of iron through Haber-Weiss's reaction, more precisely, its second-degree fenton reaction. Through this reaction, reactive oxygen species (ROS) are formed. These unstable compounds are the cause of oxidative stress that damages cellular components. Consequently, a series of reactions occur that result in increased inflammation and with the presence of hypoxia usually lead to multiorgan damage. Combined with the direct pathological and inflammatory effect of SARS-CoV-2 virus respiratory infection, the condition can progress to organe failure or even death. It is predicted that iron chelators (compounds that bind iron ions and some of the iron compounds to themselves, as well as some other metals) could have a significant therapeutic effect in the treatment of moderate and severe forms of COVID-19 infection.