prikaz prve stranice dokumenta Non-alcoholic fatty liver disease; a part of the metabolic syndrome in the renal transplant recipient and possible cause of an allograft dysfunction
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Scientific paper - Original scientific paper
Non-alcoholic fatty liver disease; a part of the metabolic syndrome in the renal transplant recipient and possible cause of an allograft dysfunction
Medical Hypotheses, 82 (2014), 1; 36-39. https://doi.org/10.1016/j.mehy.2013.10.030
Mikolašević, Ivana; Rački, Sanjin; Lukenda, V.; Pavletić-Persšč, M.; Milić, Sandra; Orlic, Lidija

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Mikolašević, I., Rački, S., Lukenda, V., Pavletić Persšč, M., Milić, S. & Orlic, L. (2014). Non-alcoholic fatty liver disease; a part of the metabolic syndrome in the renal transplant recipient and possible cause of an allograft dysfunction. Medical Hypotheses, 82. (1), 36-39. doi: 10.1016/j.mehy.2013.10.030

Mikolašević, Ivana, et al. "Non-alcoholic fatty liver disease; a part of the metabolic syndrome in the renal transplant recipient and possible cause of an allograft dysfunction." Medical Hypotheses, vol. 82, no. 1, 2014, pp. 36-39. https://doi.org/10.1016/j.mehy.2013.10.030

Mikolašević, Ivana, Sanjin Rački, V. Lukenda, M. Pavletić Persšč, Sandra Milić and Lidija Orlic. "Non-alcoholic fatty liver disease; a part of the metabolic syndrome in the renal transplant recipient and possible cause of an allograft dysfunction." Medical Hypotheses 82, no. 1 (2014): 36-39. https://doi.org/10.1016/j.mehy.2013.10.030

Mikolašević, I., et al. (2014) 'Non-alcoholic fatty liver disease; a part of the metabolic syndrome in the renal transplant recipient and possible cause of an allograft dysfunction', Medical Hypotheses, 82(1), pp. 36-39. doi: 10.1016/j.mehy.2013.10.030

Mikolašević I, Rački S, Lukenda V, Pavletić Persšč M, Milić S, Orlic L. Non-alcoholic fatty liver disease; a part of the metabolic syndrome in the renal transplant recipient and possible cause of an allograft dysfunction. Medical Hypotheses [Internet]. 2014 January [cited 2024 November 09];82(1):36-39. doi: 10.1016/j.mehy.2013.10.030

I. Mikolašević, S. Rački, V. Lukenda, M. Pavletić Persšč, S. Milić and L. Orlic, "Non-alcoholic fatty liver disease; a part of the metabolic syndrome in the renal transplant recipient and possible cause of an allograft dysfunction", Medical Hypotheses, vol. 82, no. 1, pp. 36-39, January 2014. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:615058. [Accessed: 09 November 2024]

Metadata
Title (english)Non-alcoholic fatty liver disease; a part of the metabolic syndrome in the renal transplant recipient and possible cause of an allograft dysfunction
AuthorIvana Mikolašević
AuthorSanjin Rački
AuthorV. Lukenda
AuthorM. Pavletić-Persšč
AuthorSandra Milić
AuthorLidija Orlic
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Internal Medicine)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Internal Medicine
Abstract (english)
Despite all improvements in transplant medicine, renal transplant recipients have a high risk for cardiovascular mortality. A high prevalence of cardiovascular complications in renal transplant recipients (RTR) is explained by cardiovascular risk factors present before transplantation, in addition to the development of new risk factors as well as worsening of preexisting risk factors after transplantation. A majority ot these patients develop metabolic syndrome within a year after the transplantation. The metabolic syndrome (MS) is associated with impaired renal allograft function and increased insulin resistance. Non alcoholic fatty liver disease (NAFLD) represents a liver manifestation of metabolic syndrome and it development is strongly associated with all components of MS in general population. The current importance of NAFLD and its link to the MS has encouraged an interest in its possible role in the development of atherosclerosis in recent years. Considering the fact that all components of MS are more common among renal transplant recipients compared to general population, it would be expected that RTR may have a much higher incidence of NAFLD compared to general population. We propose that the presence of NAFLD in RTR could be a strong predictor in cardiovascular morbidity and mortality. Also, according to the recent investigations about the possible link between NAFLD and chronic kidney disease, we hypothesis that NAFLD may be associated with deteriorating graft function, causing a chronic allograft nephropathy and graft loss. Common factors underlying the pathogenesis of NAFLD and chronic allograft dysfunction may be insulin resistance, oxidative stress, activation of rennin-angiotensin system, and inappropriate secretion of inflammatory cytokines by steatotic and inflamed liver. (C) 2013 Elsevier Ltd. All rights reserved.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionAccepted version
Journal titleMedical Hypotheses
Numberingvol. 82, no. 1, pp. 36-39
p-ISSN0306-9877
DOIhttps://doi.org/10.1016/j.mehy.2013.10.030
URN:NBNurn:nbn:hr:184:615058
Publication2014-01
Document URLhttps://linkinghub.elsevier.com/retrieve/pii/S0306987713005161
Type of resourceText
Access conditionsInstitutional access
Terms of useLicence In copyright icon
Created on2022-09-20 09:38:54