prikaz prve stranice dokumenta Effect of Statin Therapy Duration on Bone Turnover Markers in Dyslipidemic Patients
  Download
PDF 779.33 KB
Scientific paper - Original scientific paper
Effect of Statin Therapy Duration on Bone Turnover Markers in Dyslipidemic Patients
Periodicum biologorum, 117 (2015), 1; 73-79. urn:nbn:hr:184:727777
Cvijanović, Olga; Bićanić, Nenad; Crnčević Orlić, Željka; Klobučar- Majanović, Sanja; Turk Wensween, Tamara; Bubić, Ivan

Institutional repository: Repository of the University of Rijeka, Faculty of Medicine

Cite this document

Cvijanović, O., Bićanić, N., Crnčević Orlić, Ž., Klobučar Majanović, S., Turk Wensween, T. & Bubić, I. (2015). Effect of Statin Therapy Duration on Bone Turnover Markers in Dyslipidemic Patients. Periodicum biologorum, 117. (1), 73-79. Retrieved from https://urn.nsk.hr/urn:nbn:hr:184:727777

Cvijanović, Olga, et al. "Effect of Statin Therapy Duration on Bone Turnover Markers in Dyslipidemic Patients." Periodicum biologorum, vol. 117, no. 1, 2015, pp. 73-79. https://urn.nsk.hr/urn:nbn:hr:184:727777

Cvijanović, Olga, Nenad Bićanić, Željka Crnčević Orlić, Sanja Klobučar Majanović, Tamara Turk Wensween and Ivan Bubić. "Effect of Statin Therapy Duration on Bone Turnover Markers in Dyslipidemic Patients." Periodicum biologorum 117, no. 1 (2015): 73-79. https://urn.nsk.hr/urn:nbn:hr:184:727777

Cvijanović, O., et al. (2015) 'Effect of Statin Therapy Duration on Bone Turnover Markers in Dyslipidemic Patients', Periodicum biologorum, 117(1), pp. 73-79. Available at: https://urn.nsk.hr/urn:nbn:hr:184:727777 (Accessed 28 April 2024)

Cvijanović O, Bićanić N, Crnčević Orlić Ž, Klobučar Majanović S, Turk Wensween T, Bubić I. Effect of Statin Therapy Duration on Bone Turnover Markers in Dyslipidemic Patients. Periodicum biologorum [Internet]. 2015 [cited 2024 April 28];117(1):73-79. Available at: https://urn.nsk.hr/urn:nbn:hr:184:727777

O. Cvijanović, N. Bićanić, Ž. Crnčević Orlić, S. Klobučar Majanović, T. Turk Wensween and I. Bubić, "Effect of Statin Therapy Duration on Bone Turnover Markers in Dyslipidemic Patients", Periodicum biologorum, vol. 117, no. 1, pp. 73-79, 2015. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:727777. [Accessed: 28 April 2024]

Metadata
Title (english)Effect of Statin Therapy Duration on Bone Turnover Markers in Dyslipidemic Patients
AuthorOlga Cvijanović
AuthorNenad Bićanić
AuthorŽeljka Crnčević Orlić
AuthorSanja Klobučar- Majanović
AuthorTamara Turk Wensween
AuthorIvan Bubić
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Internal Medicine)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Internal Medicine
Abstract (english)
Background and Purpose: Statins are cholesterol-lowering drugs decreasing bone resorption by inhibition of the farnesyl diphosphate synthase step in the mevalonic acid pathway and therefore are believed to have beneficial effects on bone status. The objective was to examine the relationship between statin therapy duration and bone turnover markers in dyslipidemic patients. Patients and Methods: Two hundred and eighty subjects were divided into five groups depending on duration of statin therapy: (controls 0 yrs); (0.1-1.5 yrs); (2-5 yrs); (6-10 yrs); (11-30 yrs). ELISA method was applied on fasting serums using bone formation markers: Osteoprotegerin (pmol/l) and Osteocalcin (ng/ml) and bone resorption markers: sRANKL (pmol/l) and CrossLaps (ng/ml). In statistical analysis, multiple regressions were used. Results: A common influence of studied predictor variables was statistically significant for sRANKL, Serum CrossLaps and osteocalcin (P<0.001), while statistical significance was not found for osteoprotegerin. The largest shares of contributions were recorded in Model 2 for the statin group (40%) and BMI (36%) and in Model 1 for statin group (35%) and total cholesterol (28%). Conclusions: Statins showed favorable influence on osteocalcin and sRANKL, indicating improved bone metabolism in patients with longer duration of statin therapy.
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titlePeriodicum biologorum
Numberingvol. 117, no. 1, pp. 73-79
p-ISSN0031-5362
e-ISSN1849-0964
URN:NBNurn:nbn:hr:184:727777
Publication2015
Document URLhttps://hrcak.srce.hr/139525
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2022-10-13 13:19:12