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Scientific paper - Case study
MASSIVE CLOZAPINE OVERDOSE: WHAT TO EXPECT?
Psychiatria Danubina, 32 (2020), 3-4; 431-433. https://doi.org/10.24869/psyd.2020.431
Erdeljić Turk, Viktorija; Kučan, Marta; Vitezić, Dinko

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Erdeljić Turk, V., Kučan, M. & Vitezić, D. (2020). MASSIVE CLOZAPINE OVERDOSE: WHAT TO EXPECT?. Psychiatria Danubina, 32. (3-4), 431-433. doi: 10.24869/psyd.2020.431

Erdeljić Turk, Viktorija, et al. "MASSIVE CLOZAPINE OVERDOSE: WHAT TO EXPECT?." Psychiatria Danubina, vol. 32, no. 3-4, 2020, pp. 431-433. https://doi.org/10.24869/psyd.2020.431

Erdeljić Turk, Viktorija, Marta Kučan and Dinko Vitezić. "MASSIVE CLOZAPINE OVERDOSE: WHAT TO EXPECT?." Psychiatria Danubina 32, no. 3-4 (2020): 431-433. https://doi.org/10.24869/psyd.2020.431

Erdeljić Turk, V., Kučan, M. and Vitezić, D. (2020) 'MASSIVE CLOZAPINE OVERDOSE: WHAT TO EXPECT?', Psychiatria Danubina, 32(3-4), pp. 431-433. doi: 10.24869/psyd.2020.431

Erdeljić Turk V, Kučan M, Vitezić D. MASSIVE CLOZAPINE OVERDOSE: WHAT TO EXPECT?. Psychiatria Danubina [Internet]. 2020 December 24 [cited 2024 April 27];32(3-4):431-433. doi: 10.24869/psyd.2020.431

V. Erdeljić Turk, M. Kučan and D. Vitezić, "MASSIVE CLOZAPINE OVERDOSE: WHAT TO EXPECT?", Psychiatria Danubina, vol. 32, no. 3-4, pp. 431-433, December 2020. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:412869. [Accessed: 27 April 2024]

Metadata
Title (english)MASSIVE CLOZAPINE OVERDOSE: WHAT TO EXPECT?
AuthorViktorija Erdeljić Turk
AuthorMarta Kučan
AuthorDinko Vitezić
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Pharmacology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Clinical Pharmacology and Toxicology
Abstract (english)
Clozapine is an atypical antipsychotic drug indicated for treatment-resistant schizophrenia. Despite its superior clinical efficacy, many deleterious adverse events, including agranulocytosis, have resulted in its more judicious use (Asenjo Lobos et al. 2010). The most frequently reported symptoms of clozapine intoxication are impaired alertness and tachycardia; other symptoms include: hyperthermia, alterations in consciousness, dysarthria, ataxia, seizures, cardiac arrhythmias, excessive bronchial mucus, hypersalivation, miosis, blood dyscrasias, pancreatitis and hepatitis (Le Blaye et al. 1992, Krämer et al. 2010). Studies that evaluated the case fatality rate with various antipsychotics concluded that clozapine was far more toxic than other antipsychotics (Ferrey 2018). To the best of our knowledge, this is the fist case report describing treatment and outcomes following a massive overdose of clozapine, amounting to 46.7 times the recommended patient’s daily dose of clozapine.
Languageenglish
Publication typeScientific paper - Case study
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titlePsychiatria Danubina
Numberingvol. 32, no. 3-4, pp. 431-433
p-ISSN0353-5053
DOIhttps://doi.org/10.24869/psyd.2020.431
URN:NBNurn:nbn:hr:184:412869
Publication2020-12-24
Document URLhttp://www.psychiatria-danubina.com/UserDocsImages/pdf/dnb_vol32_no3-4/dnb_vol32_no3-4_431.pdf
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2022-10-14 07:29:29