prikaz prve stranice dokumenta Association between Insertion-Deletion Polymorphism of the Angiotensin-Converting Enzyme Gene and Treatment Response to Antipsychotic Medications: A Study of Antipsychotic-Naïve First-Episode Psychosis Patients and Nonadherent Chronic Psychosis Patients
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Scientific paper - Original scientific paper
Association between Insertion-Deletion Polymorphism of the Angiotensin-Converting Enzyme Gene and Treatment Response to Antipsychotic Medications: A Study of Antipsychotic-Naïve First-Episode Psychosis Patients and Nonadherent Chronic Psychosis Patients
International Journal of Molecular Sciences, 23 (2022), 20; 12180. https://doi.org/10.3390/ijms232012180
Nadalin, Sergej; Dević Pavlić, Sanja; Peitl, Vjekoslav; Karlović, Dalibor; Zatković, Lena; Ristić, Smiljana; Buretić-Tomljanović, Alena; Jakovac, Hrvoje

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Nadalin, S., Dević Pavlić, S., Peitl, V., Karlović, D., Zatković, L., Ristić, S. ... Jakovac, H. (2022). Association between Insertion-Deletion Polymorphism of the Angiotensin-Converting Enzyme Gene and Treatment Response to Antipsychotic Medications: A Study of Antipsychotic-Naïve First-Episode Psychosis Patients and Nonadherent Chronic Psychosis Patients. International Journal of Molecular Sciences, 23. (20). doi: 10.3390/ijms232012180

Nadalin, Sergej, et al. "Association between Insertion-Deletion Polymorphism of the Angiotensin-Converting Enzyme Gene and Treatment Response to Antipsychotic Medications: A Study of Antipsychotic-Naïve First-Episode Psychosis Patients and Nonadherent Chronic Psychosis Patients." International Journal of Molecular Sciences, vol. 23, no. 20, 2022. https://doi.org/10.3390/ijms232012180

Nadalin, Sergej, Sanja Dević Pavlić, Vjekoslav Peitl, Dalibor Karlović, Lena Zatković, Smiljana Ristić, Alena Buretić Tomljanović and Hrvoje Jakovac. "Association between Insertion-Deletion Polymorphism of the Angiotensin-Converting Enzyme Gene and Treatment Response to Antipsychotic Medications: A Study of Antipsychotic-Naïve First-Episode Psychosis Patients and Nonadherent Chronic Psychosis Patients." International Journal of Molecular Sciences 23, no. 20 (2022). https://doi.org/10.3390/ijms232012180

Nadalin, S., et al. (2022) 'Association between Insertion-Deletion Polymorphism of the Angiotensin-Converting Enzyme Gene and Treatment Response to Antipsychotic Medications: A Study of Antipsychotic-Naïve First-Episode Psychosis Patients and Nonadherent Chronic Psychosis Patients', International Journal of Molecular Sciences, 23(20). doi: 10.3390/ijms232012180

Nadalin S, Dević Pavlić S, Peitl V, Karlović D, Zatković L, Ristić S, and sur.. Association between Insertion-Deletion Polymorphism of the Angiotensin-Converting Enzyme Gene and Treatment Response to Antipsychotic Medications: A Study of Antipsychotic-Naïve First-Episode Psychosis Patients and Nonadherent Chronic Psychosis Patients. International Journal of Molecular Sciences [Internet]. 2022 October 12 [cited 2024 November 22];23(20). doi: 10.3390/ijms232012180

S. Nadalin, et al., "Association between Insertion-Deletion Polymorphism of the Angiotensin-Converting Enzyme Gene and Treatment Response to Antipsychotic Medications: A Study of Antipsychotic-Naïve First-Episode Psychosis Patients and Nonadherent Chronic Psychosis Patients", International Journal of Molecular Sciences, vol. 23, no. 20, October 2022. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:949217. [Accessed: 22 November 2024]

Metadata
Title (english)Association between Insertion-Deletion Polymorphism of the Angiotensin-Converting Enzyme Gene and Treatment Response to Antipsychotic Medications: A Study of Antipsychotic-Naïve First-Episode Psychosis Patients and Nonadherent Chronic Psychosis Patients
AuthorSergej Nadalin
AuthorSanja Dević Pavlić
AuthorVjekoslav Peitl
AuthorDalibor Karlović
AuthorLena Zatković
AuthorSmiljana Ristić
MBZ: 142283
AuthorAlena Buretić-Tomljanović
AuthorHrvoje Jakovac
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Physiology, Immunology and Pathophxsiology)
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Biology and Medical Genetics)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Psychiatry
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Human Genetics, Genomics and Proteomics
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Immunology
Abstract (english)
We investigated whether a functional insertion/deletion (I/D) polymorphism of angiotensin-converting enzyme (ACE) influenced antipsychotic treatment. At baseline, and after 8 weeks of treatment with various antipsychotic medications, we assessed patients’ Positive and Negative Syndrome Scale (PANSS) scores, PANSS factors, and metabolic-syndrome-related parameters (fasting plasma lipid and glucose levels, and body mass index). A total of 186 antipsychotic-naïve first-episode psychosis patients or nonadherent chronic psychosis individuals (99 males and 87 females) were genotyped by polymerase chain reaction analysis. The ACE-I/D polymorphism was significantly associated with changes in PANSS psychopathology only (p < 0.05). Compared to ACE-II homozygous males, ACE-DD homozygous and ACE-ID heterozygous males manifested significantly greater decreases in PANSS positive score, PANSS excitement factor, and PANSS cognitive factor. ACE-DD homozygous females manifested higher decreases in PANSS depression factor compared to ACE-II homozygous and ACE-ID heterozygous females. The polymorphism’s effect size was estimated as moderate to strong, while its contribution to the PANSS psychopathology ranged from ~5.4 to 8.7%, with the lowest contribution observed for PANSS positive score changes and the highest for PANSS depressive factor changes. Our results indicate that ACE-I/D polymorphism had a statistically significant but weak gender-specific impact on psychopathology data, and showed no association between ACE-I/D polymorphism and metabolic-syndrome-related parameters.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleInternational Journal of Molecular Sciences
Numberingvol. 23, no. 20, 12180
e-ISSN1422-0067
DOIhttps://doi.org/10.3390/ijms232012180
URN:NBNurn:nbn:hr:184:949217
Publication2022-10-12
Document URLhttps://www.mdpi.com/1422-0067/23/20/12180
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2022-10-18 08:57:18